6UB

amlodipine

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is present as a standalone ligand in 4 entries

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Chemical Component Summary
Name	amlodipine
Synonyms	~{O}3-ethyl ~{O}5-methyl (4~{S})-2-(2-azanylethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Identifiers	~{O}3-ethyl ~{O}5-methyl (4~{S})-2-(2-azanylethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Formula	C₂₀ H₂₅ Cl N₂ O₅
Molecular Weight	408.876
Type	NON-POLYMER
Isomeric SMILES	CCOC(=O)C1=C(NC(=C([C@@H]1c2ccccc2Cl)C(=O)OC)C)COCCN
InChI	InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1
InChIKey	HTIQEAQVCYTUBX-KRWDZBQOSA-N

Chemical Details
Formal Charge	0
Atom Count	53
Chiral Atom Count	1
Bond Count	54
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB09237
Name	Levamlodipine
Groups	approved investigational
Description	Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication.[L10833] Levamlodipine belongs to the dihydropyridine group of calcium channel blockers.[L10833] This medication was first marketed in Russia and India before being granted FDA approval.[L1484] The names S-amlodipine and levamlodipine may be used interchangeably as both substances are the same, however.[L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity.[A188940] Levamlodipine was granted FDA approval on 19 December 2019.[L10833]
Synonyms	Levamlodipine maleate S-amlodipine Levoamlodipine Levamlodipine
Brand Names	Levamlodipine Conjupri
Indication	Levamlodipine is indicated alone or in combination to treat hypertension in adults and children.[L10833]
Categories	Antiarrhythmic agents Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Calcium Channel Blockers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Substrates Dihydropyridine Derivatives Nicotinic Acids P-glycoprotein substrates Pyridines Selective Calcium Channel Blockers With Mainly Vascular Effects
ATC-Code	C08CA17
CAS number	103129-82-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Voltage-dependent L-type calcium channel subunit alpha-1C	MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAAL...	unknown	antagonist
Voltage-dependent L-type calcium channel subunit alpha-1D	MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTV...	unknown	antagonist
Nitric oxide synthase, endothelial	MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAP...	unknown	agonist
Nitric oxide synthase, inducible	MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLS...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate
Nitric oxide synthase, inducible	MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLS...	unknown	inducer
Nitric oxide synthase, endothelial	MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAP...	unknown	inducer
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate
Ileal sodium/bile acid cotransporter	MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMG...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682