1AD5

Crystal structure of the Src family tyrosine kinase Hck.

(1997) Nature 385: 602-609

• PubMed: 9024658 Search on PubMed
• DOI: https://doi.org/10.1038/385602a0
• Primary Citation of Related Structures:  
  1AD5, 2HCK


• PubMed Abstract: 
  

  The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

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Organizational Affiliation: 

Laboratories of Molecular Biophysics, The Rockefeller University, New York 10021, USA.