2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
Leahy, D.J., Aukhil, I., Erickson, H.P.(1996) Cell 84: 155-164
- PubMed: 8548820 
- DOI: https://doi.org/10.1016/s0092-8674(00)81002-8
- Primary Citation of Related Structures:  
1FNF - PubMed Abstract: 
We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
Organizational Affiliation: 
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA.