Download MendeleyCrystal structure of RhoA-GDP and its functional implications.
Wei, Y., Zhang, Y., Derewenda, U., Liu, X., Minor, W., Nakamoto, R.K., Somlyo, A.V., Somlyo, A.P., Derewenda, Z.S.(1997) Nat Struct Biol 4: 699-703
- PubMed: 9302995
- DOI: https://doi.org/10.1038/nsb0997-699
- Primary Citation of Related Structures:
1FTN - PubMed Abstract:
RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 A resolution crystal structure of the human RhoA-GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.
