Download MendeleyCrystal Structure of the Pleckstrin Homology Domain of Pepp1
Milburn, C.C., Komander, D., Deak, M., Alessi, D.R., Van Aalten, D.M.F.To be published.
1UPR
Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate
- PDB DOI: https://doi.org/10.2210/pdb1UPR/pdb
- Classification: SIGNALING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21
- Mutation(s): No
- Membrane Protein: Yes OPM
- Deposited: 2003-10-10 Released: 2004-10-20
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.27 Å
- R-Value Free: 0.276
- R-Value Work: 0.237
- R-Value Observed: 0.240
Starting Model: experimental
View more details
This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 4 | 123 | Homo sapiens | Mutation(s): 0 Membrane Entity: Yes |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9H4M7 (Homo sapiens) Explore Q9H4M7 Go to UniProtKB: Q9H4M7 | |||||
PHAROS: Q9H4M7 GTEx: ENSG00000105559 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9H4M7 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 4IP Query on 4IP | B [auth A] | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE C6 H16 O18 P4 CIPFCGZLFXVXBG-CNWJWELYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.27 Å
- R-Value Free: 0.276
- R-Value Work: 0.237
- R-Value Observed: 0.240
- Space Group: P 4 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 92.577 | α = 90 |
| b = 92.577 | β = 90 |
| c = 35.571 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| DENZO | data reduction |
| SCALEPACK | data scaling |
| AMoRE | phasing |
Entry History
Deposition Data
- Released Date: 2004-10-20 Deposition Author(s): Milburn, C.C., Komander, D., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Revision History (Full details and data files)
- Version 1.0: 2004-10-20
Type: Initial release - Version 1.1: 2012-05-16
Changes: Database references, Derived calculations, Non-polymer description, Other, Refinement description, Structure summary, Version format compliance - Version 1.2: 2016-12-07
Changes: Database references - Version 1.3: 2023-12-13
Changes: Data collection, Database references, Derived calculations, Other, Refinement description
