Download MendeleyCrystal structure of the second bromodomain of the human Brd2 protein
Padmanabhan, B., Yokoyama, S.To be published.
2DVV
Crystal structure of the second bromodomain of the human Brd2 protein
- PDB DOI: https://doi.org/10.2210/pdb2DVV/pdb
- Classification: TRANSCRIPTION
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2006-08-01 Released: 2007-08-07
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.239
- R-Value Work: 0.188
- R-Value Observed: 0.188
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
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(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Bromodomain-containing protein 2 | 112 | Homo sapiens | Mutation(s): 0 Gene Names: BRD2, KIAA9001, RING3 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P25440 (Homo sapiens) Explore P25440 Go to UniProtKB: P25440 | |||||
PHAROS: P25440 GTEx: ENSG00000204256 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P25440 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| EPE Query on EPE | B [auth A] | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID C8 H18 N2 O4 S JKMHFZQWWAIEOD-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.239
- R-Value Work: 0.188
- R-Value Observed: 0.188
- Space Group: P 21 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 71.782 | α = 90 |
| b = 52.604 | β = 90 |
| c = 32.059 | γ = 90 |
| Software Name | Purpose |
|---|---|
| MOLREP | phasing |
| CNS | refinement |
| HKL-2000 | data reduction |
| SCALEPACK | data scaling |
Entry History
Deposition Data
- Released Date: 2007-08-07 Deposition Author(s): Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Revision History (Full details and data files)
- Version 1.0: 2007-08-07
Type: Initial release - Version 1.1: 2011-07-13
Changes: Version format compliance - Version 1.2: 2023-10-25
Changes: Data collection, Database references, Derived calculations, Refinement description
