2DYL

Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)

PDB DOI: https://doi.org/10.2210/pdb2DYL/pdb

Classification: TRANSFERASE
Organism(s): Homo sapiens
Mutation(s): Yes

Deposited: 2006-09-15 Released: 2007-08-28
Deposition Author(s): Kukimoto-Niino, M., Takagi, T., Kaminishi, T., Uchikubo-Kamo, T., Terada, T., Matsuzaki, O., Shirouzu, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.45 Å
R-Value Free: 0.283
R-Value Work: 0.217
R-Value Observed: 0.217

Starting Model: experimental
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wwPDB Validation 3D Report Full Report

This is version 1.3 of the entry. See complete history.

Literature

Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)

Kukimoto-Niino, M., Takagi, T., Kaminishi, T., Uchikubo-Kamo, T., Terada, T., Matsuzaki, O., Shirouzu, M., Yokoyama, S.

To be published.

Macromolecule Content

Total Structure Weight: 35.76 kDa
Atom Count: 2,233
Modelled Residue Count: 272
Deposited Residue Count: 318
Unique protein chains: 1

Macromolecules

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Dual specificity mitogen-activated protein kinase kinase 7	A	318	Homo sapiens	Mutation(s): 2 EC: 2.7.12.2
UniProt & NIH Common Fund Data Resources
Find proteins for O14733 (Homo sapiens) Explore O14733 Go to UniProtKB: O14733
PHAROS: O14733 GTEx: ENSG00000076984
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	O14733
Sequence Annotations Expand
Reference Sequence

Experimental Data & Validation

Experimental Data

Method: X-RAY DIFFRACTION
Resolution: 2.45 Å
R-Value Free: 0.283
R-Value Work: 0.217
R-Value Observed: 0.217
Space Group: P 2₁ 2₁ 2₁

Unit Cell:

Length ( Å )	Angle ( ˚ )
a = 61.552	α = 90
b = 69.635	β = 90
c = 84.035	γ = 90

Software Package:

Software Name	Purpose
CNS	refinement
ADSC	data collection
HKL-2000	data reduction
HKL-2000	data scaling
MOLREP	phasing

Structure Validation

View Full Validation Report

Entry History

Deposition Data

Released Date: 2007-08-28

Deposition Author(s):

Kukimoto-Niino, M.

Uchikubo-Kamo, T.

RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Revision History (Full details and data files)

Version 1.0: 2007-08-28
Type: Initial release
Version 1.1: 2011-07-13
Changes: Version format compliance
Version 1.2: 2021-11-10
Changes: Database references
Version 1.3: 2023-10-25
Changes: Data collection, Refinement description

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.