Download MendeleyCrystal Structure of Human Zinc-Binding Alcohol Dehydrogenase 1
Shafqat, N., Yue, W.W., Niesen, F., Oppermann, U.To be published.
2W4Q
Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary complex with NADP and 18beta-glycyrrhetinic acid
- PDB DOI: https://doi.org/10.2210/pdb2W4Q/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2008-11-30 Released: 2009-01-20
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.223
- R-Value Work: 0.177
- R-Value Observed: 0.180
Starting Model: experimental
View more details
This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| PROSTAGLANDIN REDUCTASE 2 | 357 | Homo sapiens | Mutation(s): 0 EC: 1.3.1.48 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8N8N7 (Homo sapiens) Explore Q8N8N7 Go to UniProtKB: Q8N8N7 | |||||
PHAROS: Q8N8N7 GTEx: ENSG00000140043 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8N8N7 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAP Query on NAP | B [auth A] | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE C21 H28 N7 O17 P3 XJLXINKUBYWONI-NNYOXOHSSA-N |  | ||
| CBW Query on CBW | C [auth A], D [auth A] | (3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID C30 H46 O4 MPDGHEJMBKOTSU-YKLVYJNSSA-N |  | ||
| SO4 Query on SO4 | E [auth A], F [auth A], G [auth A], H [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 Å
- R-Value Free: 0.223
- R-Value Work: 0.177
- R-Value Observed: 0.180
- Space Group: C 1 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 69.374 | α = 90 |
| b = 84.11 | β = 109.05 |
| c = 72.888 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2009-01-20 Deposition Author(s): Shafqat, N., Yue, W.W., Ugochukwu, E., Picaud, S., Niesen, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Revision History (Full details and data files)
- Version 1.0: 2009-01-20
Type: Initial release - Version 1.1: 2011-07-13
Changes: Advisory, Version format compliance - Version 1.2: 2013-12-04
Changes: Non-polymer description, Refinement description, Source and taxonomy - Version 1.3: 2023-12-13
Changes: Data collection, Database references, Derived calculations, Other, Refinement description
