Download MendeleyCrystal structure of HIF prolyl hydroxylase in complex with a biologically active inhibitor
Evdokimov, A.G., Walter, R.L., Mekel, M., Pokross, M.E., Kawamoto, R., Boyer, A.To be published.
2HBU
Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor
- PDB DOI: https://doi.org/10.2210/pdb2HBU/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2006-06-14 Released: 2006-06-27
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.85 Å
- R-Value Free: 0.231
- R-Value Work: 0.179
- R-Value Observed: 0.181
Starting Model: experimental
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This is version 1.4 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Egl nine homolog 1 | 247 | Homo sapiens | Mutation(s): 0 Gene Names: EGLN1 EC: 1.14.11 (PDB Primary Data), 1.14.11.29 (UniProt) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9GZT9 (Homo sapiens) Explore Q9GZT9 Go to UniProtKB: Q9GZT9 | |||||
PHAROS: Q9GZT9 GTEx: ENSG00000135766 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9GZT9 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| UN9 Query on UN9 | C [auth A] | N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE C12 H9 Cl N2 O4 OUQVKRKGTAUJQA-UHFFFAOYSA-N |  | ||
| FE2 Query on FE2 | B [auth A] | FE (II) ION Fe CWYNVVGOOAEACU-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.85 Å
- R-Value Free: 0.231
- R-Value Work: 0.179
- R-Value Observed: 0.181
- Space Group: P 63
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 111.045 | α = 90 |
| b = 111.045 | β = 90 |
| c = 40.126 | γ = 120 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| MAR345 | data collection |
| HKL-2000 | data scaling |
| AMoRE | phasing |
Entry History
Deposition Data
- Released Date: 2006-06-27 Deposition Author(s): Evdokimov, A.G., Walter, R.L., Mekel, M., Pokross, M.E., Kawamoto, R., Boyer, A.
Revision History (Full details and data files)
- Version 1.0: 2006-06-27
Type: Initial release - Version 1.1: 2008-05-01
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2017-10-18
Changes: Refinement description - Version 1.4: 2023-08-30
Changes: Data collection, Database references, Derived calculations, Refinement description
