Download MendeleyCrystal structure of human transthyretin variant A25T - #1
Palmieri, L.C., Freire, J.B.B., Palhano, F.L., Azevedo, E.P.C., Foguel, D., Lima, L.M.T.R.To be published.
3I9A
Crystal structure of human transthyretin variant A25T - #1
- PDB DOI: https://doi.org/10.2210/pdb3I9A/pdb
- Classification: HORMONE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2009-07-10 Released: 2010-08-25
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.65 Å
- R-Value Free: 0.227
- R-Value Work: 0.203
- R-Value Observed: 0.204
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.4 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Transthyretin | 127 | Homo sapiens | Mutation(s): 1 Gene Names: TTR, PALB |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P02766 (Homo sapiens) Explore P02766 Go to UniProtKB: P02766 | |||||
PHAROS: P02766 GTEx: ENSG00000118271 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P02766 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PGE Query on PGE | C [auth A], D [auth B] | TRIETHYLENE GLYCOL C6 H14 O4 ZIBGPFATKBEMQZ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.65 Å
- R-Value Free: 0.227
- R-Value Work: 0.203
- R-Value Observed: 0.204
- Space Group: P 21 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 45.08 | α = 90 |
| b = 87.83 | β = 90 |
| c = 66.55 | γ = 90 |
| Software Name | Purpose |
|---|---|
| MOSFLM | data reduction |
| SCALA | data scaling |
| MOLREP | phasing |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| MAR345dtb | data collection |
Entry History
Deposition Data
- Released Date: 2010-08-25 Deposition Author(s): Palmieri, L.C., Freire, J.B.B., Palhano, F.L., Azevedo, E.P.C., Foguel, D., Lima, L.M.T.R.
Revision History (Full details and data files)
- Version 1.0: 2010-08-25
Type: Initial release - Version 1.1: 2011-07-13
Changes: Version format compliance - Version 1.2: 2019-09-25
Changes: Advisory, Data collection, Derived calculations - Version 1.3: 2021-10-13
Changes: Database references, Derived calculations - Version 1.4: 2023-09-06
Changes: Data collection, Refinement description
