Download MendeleyCrystal structure of human N12-i2 Fab, an ADCC and neutralizing anti-HIV-1 Env antibody
Guan, Y., DeVico, A.L., Lewis, G.K., Pazgier, M.To be published.
3QEG
Crystal structure of human N12-i2 Fab, an ADCC and neutralizing anti-HIV-1 Env antibody
- PDB DOI: https://doi.org/10.2210/pdb3QEG/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens
- Mutation(s): No
- Deposited: 2011-01-20 Released: 2012-01-25
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.95 Å
- R-Value Free: 0.236
- R-Value Work: 0.203
- R-Value Observed: 0.205
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Fab fragment of human anti-HIV antibody N12-i2, heavy chain | A [auth H] | 239 | Homo sapiens | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Fab fragment of human anti-HIV antibody N12-i2, light chain | B [auth L] | 215 | Homo sapiens | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.95 Å
- R-Value Free: 0.236
- R-Value Work: 0.203
- R-Value Observed: 0.205
- Space Group: P 61 2 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 78.906 | α = 90 |
| b = 78.906 | β = 90 |
| c = 315.147 | γ = 120 |
| Software Name | Purpose |
|---|---|
| HKL-2000 | data collection |
| PHASER | phasing |
| REFMAC | refinement |
| DENZO | data reduction |
| SCALEPACK | data scaling |
Entry History
Deposition Data
- Released Date: 2012-01-25 Deposition Author(s): Guan, Y., DeVico, A.L., Lewis, G.K., Pazgier, M.
Revision History (Full details and data files)
- Version 1.0: 2012-01-25
Type: Initial release - Version 1.1: 2023-09-13
Changes: Data collection, Database references, Refinement description - Version 1.2: 2024-11-27
Changes: Structure summary
