Structural Basis for Hijacking Siderophore Receptors by Antimicrobial Lasso Peptides.
Mathavan, I., Zirah, S., Mehmood, S., Choudhury, H.G., Goulard, C., Li, Y., Robinson, C.V., Rebuffat, S., Beis, K.(2014) Nat Chem Biol 10: 340
- PubMed: 24705590 
- DOI: https://doi.org/10.1038/nchembio.1499
- Primary Citation of Related Structures:  
4CU4 - PubMed Abstract: 
The lasso peptide microcin J25 is known to hijack the siderophore receptor FhuA for initiating internalization. Here, we provide what is to our knowledge the first structural evidence on the recognition mechanism, and our biochemical data show that another closely related lasso peptide cannot interact with FhuA. Our work provides an explanation on the narrow activity spectrum of lasso peptides and opens the path to the development of new antibacterials.
Organizational Affiliation: 
1] Department of Life Sciences, Imperial College London, London, UK. [2] Membrane Protein Lab, Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Oxfordshire, UK. [3] Rutherford Appleton Laboratory, Research Complex at Harwell, Didcot, Oxfordshire, UK.