5DOX

Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.10 Å
  • R-Value Free: 0.284 
  • R-Value Work: 0.232 
  • R-Value Observed: 0.235 

Starting Model: experimental
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This is version 1.6 of the entry. See complete history. 


Literature

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K.A., Blanchard, S.C., Steitz, T.A., Wilson, D.N.

(2015) Mol Cell 58: 832-844

  • DOI: https://doi.org/10.1016/j.molcel.2015.04.014
  • Primary Citation of Related Structures:  
    4Z3S, 5DOX, 5DOY

  • PubMed Abstract: 

    The increase in multi-drug-resistant bacteria is limiting the effectiveness of currently approved antibiotics, leading to a renewed interest in antibiotics with distinct chemical scaffolds. We have solved the structures of the Thermus thermophilus 70S ribosome with A-, P-, and E-site tRNAs bound and in complex with either the aminocyclitol-containing antibiotic hygromycin A (HygA) or the nucleoside antibiotic A201A. Both antibiotics bind at the peptidyl transferase center and sterically occlude the CCA-end of the A-tRNA from entering the A site of the peptidyl transferase center. Single-molecule Förster resonance energy transfer (smFRET) experiments reveal that HygA and A201A specifically interfere with full accommodation of the A-tRNA, leading to the presence of tRNA accommodation intermediates and thereby inhibiting peptide bond formation. Thus, our results provide not only insight into the mechanism of action of HygA and A201A, but also into the fundamental process of tRNA accommodation during protein synthesis.

    • Organizational Affiliation: 

    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.


Macromolecules

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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L2C [auth 1D],
CB [auth 2D]		276Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L3D [auth 1E],
DB [auth 2E]		206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L4E [auth 1F],
EB [auth 2F]		210Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L5F [auth 1G],
FB [auth 2G]		182Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L6G [auth 1H],
GB [auth 2H]		180Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L9H [auth 1I],
HB [auth 2I]		148Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L13I [auth 1N],
IB [auth 2N]		140Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L14J [auth 1O],
JB [auth 2O]		122Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L15K [auth 1P],
KB [auth 2P]		150Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L16L [auth 1Q],
LB [auth 2Q]		141Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L17M [auth 1R],
MB [auth 2R]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L18N [auth 1S],
NB [auth 2S]		112Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L19O [auth 1T],
OB [auth 2T]		146Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L20P [auth 1U],
PB [auth 2U]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L21Q [auth 1V],
QB [auth 2V]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L22R [auth 1W],
RB [auth 2W]		113Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L23S [auth 1X],
SB [auth 2X]		96Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L24T [auth 1Y],
TB [auth 2Y]		110Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L25U [auth 1Z],
UB [auth 2Z]		206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 22
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L27V [auth 10],
VB [auth 20]		85Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 23
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L28W [auth 11],
WB [auth 21]		98Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L29X [auth 12],
XB [auth 22]		72Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 25
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L30Y [auth 13],
YB [auth 23]		60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L31Z [auth 14],
ZB [auth 24]		71Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L32AA [auth 15],
AC [auth 25]		60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L33BA [auth 16],
BC [auth 26]		54Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L34CA [auth 17],
CC [auth 27]		49Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L35DA [auth 18],
DC [auth 28]		65Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 31
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L36EA [auth 19],
EC [auth 29]		37Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S2GA [auth 1b],
GC [auth 2b]		256Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 34
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S3HA [auth 1c],
HC [auth 2c]		239Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S4IA [auth 1d],
IC [auth 2d]		209Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S5JA [auth 1e],
JC [auth 2e]		162Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S6KA [auth 1f],
KC [auth 2f]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S7LA [auth 1g],
LC [auth 2g]		156Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S8MA [auth 1h],
MC [auth 2h]		138Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S9NA [auth 1i],
NC [auth 2i]		128Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S10OA [auth 1j],
OC [auth 2j]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S11PA [auth 1k],
PC [auth 2k]		129Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S12QA [auth 1l],
QC [auth 2l]		132Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S13RA [auth 1m],
RC [auth 2m]		126Thermus thermophilus HB8Mutation(s): 0 
UniProt
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UniProt GroupP80377
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S14 type ZSA [auth 1n],
SC [auth 2n]		61Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S15TA [auth 1o],
TC [auth 2o]		89Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SJ76 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SJ76
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S16UA [auth 1p],
UC [auth 2p]		88Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SJH3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SJH3
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S17VA [auth 1q],
VC [auth 2q]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S18WA [auth 1r],
WC [auth 2r]		88Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SLQ0 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ5SLQ0
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S19XA [auth 1s],
XC [auth 2s]		93Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SHP2 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SHP2
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S20YA [auth 1t],
YC [auth 2t]		106Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for P80380 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP80380
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein ThxZA [auth 1u],
ZC [auth 2u]		27Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SIH3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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UniProt GroupQ5SIH3
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Entity ID: 1
MoleculeChains LengthOrganismImage
23S Ribosomal RNAA [auth 1A],
AB [auth 2A]		2,915Thermus thermophilus HB8
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Entity ID: 2
MoleculeChains LengthOrganismImage
5S Ribosomal RNAB [auth 1B],
BB [auth 2B]		121Thermus thermophilus HB8
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Entity ID: 32
MoleculeChains LengthOrganismImage
16S Ribosomal RNAFA [auth 1a],
FC [auth 2a]		1,521Thermus thermophilus HB8
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Small Molecules
Ligands 4 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
HGR
Query on HGR
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HKB [auth 2A],
UFA [auth 1A]		Hygromycin A
C23 H29 N O12
LDTRVHIISSLXOQ-IIHALWDASA-N
SF4
Query on SF4
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LRB [auth 2d],
WPA [auth 1d]		IRON/SULFUR CLUSTER
Fe4 S4
LJBDFODJNLIPKO-UHFFFAOYSA-N
ZN
Query on ZN
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EKA [auth 19]
EMB [auth 2Y]
HJA [auth 1Y]
HMB [auth 24]
HQA [auth 1n]
EKA [auth 19],
EMB [auth 2Y],
HJA [auth 1Y],
HMB [auth 24],
HQA [auth 1n],
IMB [auth 25],
JMB [auth 26],
MMB [auth 29],
QRB [auth 2n],
SJA [auth 14],
VJA [auth 15],
ZJA [auth 16]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
MG
Query on MG
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AAA [auth 1A]
AAB [auth 2A]
ABA [auth 1A]
ABB [auth 2A]
ACA [auth 1A]
AAA [auth 1A],
AAB [auth 2A],
ABA [auth 1A],
ABB [auth 2A],
ACA [auth 1A],
ACB [auth 2A],
AD [auth 1A],
ADA [auth 1A],
ADB [auth 2A],
AE [auth 1A],
AEA [auth 1A],
AEB [auth 2A],
AF [auth 1A],
AFA [auth 1A],
AFB [auth 2A],
AG [auth 1A],
AGA [auth 1A],
AGB [auth 2A],
AH [auth 1A],
AHA [auth 1B],
AHB [auth 2A],
AI [auth 1A],
AIA [auth 1F],
AIB [auth 2A],
AJ [auth 1A],
AJA [auth 1U],
AJB [auth 2A],
AK [auth 1A],
AKA [auth 17],
AKB [auth 2A],
AL [auth 1A],
ALA [auth 1a],
ALB [auth 2B],
AM [auth 1A],
AMA [auth 1a],
AMB [auth 2T],
AN [auth 1A],
ANA [auth 1a],
ANB [auth 2a],
AO [auth 1A],
AOA [auth 1a],
AOB [auth 2a],
AP [auth 1A],
APA [auth 1a],
APB [auth 2a],
AQ [auth 1A],
AQA [auth 1f],
AQB [auth 2a],
AR [auth 1A],
ARA [auth 2A],
ARB [auth 2a],
AS [auth 1A],
ASA [auth 2A],
AT [auth 1A],
ATA [auth 2A],
AU [auth 1A],
AUA [auth 2A],
AV [auth 1A],
AVA [auth 2A],
AW [auth 1A],
AWA [auth 2A],
AX [auth 1A],
AXA [auth 2A],
AY [auth 1A],
AYA [auth 2A],
AZ [auth 1A],
AZA [auth 2A],
BAA [auth 1A],
BAB [auth 2A],
BBA [auth 1A],
BBB [auth 2A],
BCA [auth 1A],
BCB [auth 2A],
BD [auth 1A],
BDA [auth 1A],
BDB [auth 2A],
BE [auth 1A],
BEA [auth 1A],
BEB [auth 2A],
BF [auth 1A],
BFA [auth 1A],
BFB [auth 2A],
BG [auth 1A],
BGA [auth 1A],
BGB [auth 2A],
BH [auth 1A],
BHA [auth 1B],
BHB [auth 2A],
BI [auth 1A],
BIA [auth 1F],
BIB [auth 2A],
BJ [auth 1A],
BJA [auth 1U],
BJB [auth 2A],
BK [auth 1A],
BKA [auth 17],
BKB [auth 2A],
BL [auth 1A],
BLA [auth 1a],
BLB [auth 2B],
BM [auth 1A],
BMA [auth 1a],
BMB [auth 2V],
BN [auth 1A],
BNA [auth 1a],
BNB [auth 2a],
BO [auth 1A],
BOA [auth 1a],
BOB [auth 2a],
BP [auth 1A],
BPA [auth 1a],
BPB [auth 2a],
BQ [auth 1A],
BQA [auth 1g],
BQB [auth 2a],
BR [auth 1A],
BRA [auth 2A],
BRB [auth 2a],
BS [auth 1A],
BSA [auth 2A],
BT [auth 1A],
BTA [auth 2A],
BU [auth 1A],
BUA [auth 2A],
BV [auth 1A],
BVA [auth 2A],
BW [auth 1A],
BWA [auth 2A],
BX [auth 1A],
BXA [auth 2A],
BY [auth 1A],
BYA [auth 2A],
BZ [auth 1A],
BZA [auth 2A],
CAA [auth 1A],
CAB [auth 2A],
CBA [auth 1A],
CBB [auth 2A],
CCA [auth 1A],
CCB [auth 2A],
CD [auth 1A],
CDA [auth 1A],
CDB [auth 2A],
CE [auth 1A],
CEA [auth 1A],
CEB [auth 2A],
CF [auth 1A],
CFA [auth 1A],
CFB [auth 2A],
CG [auth 1A],
CGA [auth 1A],
CGB [auth 2A],
CH [auth 1A],
CHA [auth 1B],
CHB [auth 2A],
CI [auth 1A],
CIA [auth 1F],
CIB [auth 2A],
CJ [auth 1A],
CJA [auth 1V],
CJB [auth 2A],
CK [auth 1A],
CKA [auth 18],
CKB [auth 2A],
CL [auth 1A],
CLA [auth 1a],
CLB [auth 2B],
CM [auth 1A],
CMA [auth 1a],
CMB [auth 2W],
CN [auth 1A],
CNA [auth 1a],
CNB [auth 2a],
CO [auth 1A],
COA [auth 1a],
COB [auth 2a],
CP [auth 1A],
CPA [auth 1a],
CPB [auth 2a],
CQ [auth 1A],
CQA [auth 1g],
CQB [auth 2a],
CR [auth 1A],
CRA [auth 2A],
CRB [auth 2a],
CS [auth 1A],
CSA [auth 2A],
CT [auth 1A],
CTA [auth 2A],
CU [auth 1A],
CUA [auth 2A],
CV [auth 1A],
CVA [auth 2A],
CW [auth 1A],
CWA [auth 2A],
CX [auth 1A],
CXA [auth 2A],
CY [auth 1A],
CYA [auth 2A],
CZ [auth 1A],
CZA [auth 2A],
DAA [auth 1A],
DAB [auth 2A],
DBA [auth 1A],
DBB [auth 2A],
DCA [auth 1A],
DCB [auth 2A],
DD [auth 1A],
DDA [auth 1A],
DDB [auth 2A],
DE [auth 1A],
DEA [auth 1A],
DEB [auth 2A],
DF [auth 1A],
DFA [auth 1A],
DFB [auth 2A],
DG [auth 1A],
DGA [auth 1A],
DGB [auth 2A],
DH [auth 1A],
DHA [auth 1B],
DHB [auth 2A],
DI [auth 1A],
DIA [auth 1F],
DIB [auth 2A],
DJ [auth 1A],
DJA [auth 1V],
DJB [auth 2A],
DK [auth 1A],
DKA [auth 19],
DKB [auth 2A],
DL [auth 1A],
DLA [auth 1a],
DLB [auth 2B],
DM [auth 1A],
DMA [auth 1a],
DMB [auth 2X],
DN [auth 1A],
DNA [auth 1a],
DNB [auth 2a],
DO [auth 1A],
DOA [auth 1a],
DOB [auth 2a],
DP [auth 1A],
DPA [auth 1a],
DPB [auth 2a],
DQ [auth 1A],
DQA [auth 1h],
DQB [auth 2a],
DR [auth 1A],
DRA [auth 2A],
DRB [auth 2a],
DS [auth 1A],
DSA [auth 2A],
DT [auth 1A],
DTA [auth 2A],
DU [auth 1A],
DUA [auth 2A],
DV [auth 1A],
DVA [auth 2A],
DW [auth 1A],
DWA [auth 2A],
DX [auth 1A],
DXA [auth 2A],
DY [auth 1A],
DYA [auth 2A],
DZ [auth 1A],
DZA [auth 2A],
EAA [auth 1A],
EAB [auth 2A],
EBA [auth 1A],
EBB [auth 2A],
ECA [auth 1A],
ECB [auth 2A],
ED [auth 1A],
EDA [auth 1A],
EDB [auth 2A],
EE [auth 1A],
EEA [auth 1A],
EEB [auth 2A],
EF [auth 1A],
EFA [auth 1A],
EFB [auth 2A],
EG [auth 1A],
EGA [auth 1A],
EGB [auth 2A],
EH [auth 1A],
EHA [auth 1B],
EHB [auth 2A],
EI [auth 1A],
EIA [auth 1F],
EIB [auth 2A],
EJ [auth 1A],
EJA [auth 1W],
EJB [auth 2A],
EK [auth 1A],
EKB [auth 2A],
EL [auth 1A],
ELA [auth 1a],
ELB [auth 2D],
EM [auth 1A],
EMA [auth 1a],
EN [auth 1A],
ENA [auth 1a],
ENB [auth 2a],
EO [auth 1A],
EOA [auth 1a],
EOB [auth 2a],
EP [auth 1A],
EPA [auth 1a],
EPB [auth 2a],
EQ [auth 1A],
EQA [auth 1k],
EQB [auth 2a],
ER [auth 1A],
ERA [auth 2A],
ERB [auth 2a],
ES [auth 1A],
ESA [auth 2A],
ET [auth 1A],
ETA [auth 2A],
EU [auth 1A],
EUA [auth 2A],
EV [auth 1A],
EVA [auth 2A],
EW [auth 1A],
EWA [auth 2A],
EX [auth 1A],
EXA [auth 2A],
EY [auth 1A],
EYA [auth 2A],
EZ [auth 1A],
EZA [auth 2A],
FAA [auth 1A],
FAB [auth 2A],
FBA [auth 1A],
FBB [auth 2A],
FCA [auth 1A],
FCB [auth 2A],
FD [auth 1A],
FDA [auth 1A],
FDB [auth 2A],
FE [auth 1A],
FEA [auth 1A],
FEB [auth 2A],
FF [auth 1A],
FFA [auth 1A],
FFB [auth 2A],
FG [auth 1A],
FGA [auth 1A],
FGB [auth 2A],
FH [auth 1A],
FHA [auth 1B],
FHB [auth 2A],
FI [auth 1A],
FIA [auth 1G],
FIB [auth 2A],
FJ [auth 1A],
FJA [auth 1W],
FJB [auth 2A],
FK [auth 1A],
FKA [auth 19],
FKB [auth 2A],
FL [auth 1A],
FLA [auth 1a],
FLB [auth 2D],
FM [auth 1A],
FMA [auth 1a],
FMB [auth 2Y],
FN [auth 1A],
FNA [auth 1a],
FNB [auth 2a],
FO [auth 1A],
FOA [auth 1a],
FOB [auth 2a],
FP [auth 1A],
FPA [auth 1a],
FPB [auth 2a],
FQ [auth 1A],
FQA [auth 1l],
FQB [auth 2a],
FR [auth 1A],
FRA [auth 2A],
FRB [auth 2a],
FS [auth 1A],
FSA [auth 2A],
FT [auth 1A],
FTA [auth 2A],
FU [auth 1A],
FUA [auth 2A],
FV [auth 1A],
FVA [auth 2A],
FW [auth 1A],
FWA [auth 2A],
FX [auth 1A],
FXA [auth 2A],
FY [auth 1A],
FYA [auth 2A],
FZ [auth 1A],
FZA [auth 2A],
GAA [auth 1A],
GAB [auth 2A],
GBA [auth 1A],
GBB [auth 2A],
GCA [auth 1A],
GCB [auth 2A],
GD [auth 1A],
GDA [auth 1A],
GDB [auth 2A],
GE [auth 1A],
GEA [auth 1A],
GEB [auth 2A],
GF [auth 1A],
GFA [auth 1A],
GFB [auth 2A],
GG [auth 1A],
GGA [auth 1A],
GGB [auth 2A],
GH [auth 1A],
GHA [auth 1B],
GHB [auth 2A],
GI [auth 1A],
GIA [auth 1G],
GIB [auth 2A],
GJ [auth 1A],
GJA [auth 1X],
GJB [auth 2A],
GK [auth 1A],
GKA [auth 19],
GKB [auth 2A],
GL [auth 1A],
GLA [auth 1a],
GLB [auth 2D],
GM [auth 1A],
GMA [auth 1a],
GMB [auth 20],
GN [auth 1A],
GNA [auth 1a],
GNB [auth 2a],
GO [auth 1A],
GOA [auth 1a],
GOB [auth 2a],
GP [auth 1A],
GPA [auth 1a],
GPB [auth 2a],
GQ [auth 1A],
GQA [auth 1l],
GQB [auth 2a],
GR [auth 1A],
GRA [auth 2A],
GRB [auth 2a],
GS [auth 1A],
GSA [auth 2A],
GT [auth 1A],
GTA [auth 2A],
GU [auth 1A],
GUA [auth 2A],
GV [auth 1A],
GVA [auth 2A],
GW [auth 1A],
GWA [auth 2A],
GX [auth 1A],
GXA [auth 2A],
GY [auth 1A],
GYA [auth 2A],
GZ [auth 1A],
GZA [auth 2A],
HAA [auth 1A],
HAB [auth 2A],
HBA [auth 1A],
HBB [auth 2A],
HCA [auth 1A],
HCB [auth 2A],
HD [auth 1A],
HDA [auth 1A],
HDB [auth 2A],
HE [auth 1A],
HEA [auth 1A],
HEB [auth 2A],
HF [auth 1A],
HFA [auth 1A],
HFB [auth 2A],
HG [auth 1A],
HGA [auth 1A],
HGB [auth 2A],
HH [auth 1A],
HHA [auth 1B],
HHB [auth 2A],
HI [auth 1A],
HIA [auth 1H],
HIB [auth 2A],
HJ [auth 1A],
HJB [auth 2A],
HK [auth 1A],
HKA [auth 19],
HL [auth 1A],
HLA [auth 1a],
HLB [auth 2E],
HM [auth 1A],
HMA [auth 1a],
HN [auth 1A],
HNA [auth 1a],
HNB [auth 2a],
HO [auth 1A],
HOA [auth 1a],
HOB [auth 2a],
HP [auth 1A],
HPA [auth 1a],
HPB [auth 2a],
HQ [auth 1A],
HQB [auth 2a],
HR [auth 1A],
HRA [auth 2A],
HRB [auth 2a],
HS [auth 1A],
HSA [auth 2A],
HT [auth 1A],
HTA [auth 2A],
HU [auth 1A],
HUA [auth 2A],
HV [auth 1A],
HVA [auth 2A],
HW [auth 1A],
HWA [auth 2A],
HX [auth 1A],
HXA [auth 2A],
HY [auth 1A],
HYA [auth 2A],
HZ [auth 1A],
HZA [auth 2A],
IAA [auth 1A],
IAB [auth 2A],
IBA [auth 1A],
IBB [auth 2A],
ICA [auth 1A],
ICB [auth 2A],
ID [auth 1A],
IDA [auth 1A],
IDB [auth 2A],
IE [auth 1A],
IEA [auth 1A],
IEB [auth 2A],
IF [auth 1A],
IFA [auth 1A],
IFB [auth 2A],
IG [auth 1A],
IGA [auth 1A],
IGB [auth 2A],
IH [auth 1A],
IHA [auth 1B],
IHB [auth 2A],
II [auth 1A],
IIA [auth 1H],
IIB [auth 2A],
IJ [auth 1A],
IJA [auth 1Z],
IJB [auth 2A],
IK [auth 1A],
IKA [auth 1a],
IKB [auth 2A],
IL [auth 1A],
ILA [auth 1a],
ILB [auth 2E],
IM [auth 1A],
IMA [auth 1a],
IN [auth 1A],
INA [auth 1a],
INB [auth 2a],
IO [auth 1A],
IOA [auth 1a],
IOB [auth 2a],
IP [auth 1A],
IPA [auth 1a],
IPB [auth 2a],
IQ [auth 1A],
IQA [auth 1o],
IQB [auth 2a],
IR [auth 1A],
IRA [auth 2A],
IRB [auth 2a],
IS [auth 1A],
ISA [auth 2A],
IT [auth 1A],
ITA [auth 2A],
IU [auth 1A],
IUA [auth 2A],
IV [auth 1A],
IVA [auth 2A],
IW [auth 1A],
IWA [auth 2A],
IX [auth 1A],
IXA [auth 2A],
IY [auth 1A],
IYA [auth 2A],
IZ [auth 1A],
IZA [auth 2A],
JAA [auth 1A],
JAB [auth 2A],
JBA [auth 1A],
JBB [auth 2A],
JCA [auth 1A],
JCB [auth 2A],
JD [auth 1A],
JDA [auth 1A],
JDB [auth 2A],
JE [auth 1A],
JEA [auth 1A],
JEB [auth 2A],
JF [auth 1A],
JFA [auth 1A],
JFB [auth 2A],
JG [auth 1A],
JGA [auth 1A],
JGB [auth 2A],
JH [auth 1A],
JHA [auth 1B],
JHB [auth 2A],
JI [auth 1A],
JIA [auth 1N],
JIB [auth 2A],
JJ [auth 1A],
JJA [auth 10],
JJB [auth 2A],
JK [auth 1A],
JKA [auth 1a],
JKB [auth 2A],
JL [auth 1A],
JLA [auth 1a],
JLB [auth 2E],
JM [auth 1A],
JMA [auth 1a],
JN [auth 1A],
JNA [auth 1a],
JNB [auth 2a],
JO [auth 1A],
JOA [auth 1a],
JOB [auth 2a],
JP [auth 1A],
JPA [auth 1a],
JPB [auth 2a],
JQ [auth 1A],
JQA [auth 1o],
JQB [auth 2a],
JR [auth 1A],
JRA [auth 2A],
JRB [auth 2a],
JS [auth 1A],
JSA [auth 2A],
JT [auth 1A],
JTA [auth 2A],
JU [auth 1A],
JUA [auth 2A],
JV [auth 1A],
JVA [auth 2A],
JW [auth 1A],
JWA [auth 2A],
JX [auth 1A],
JXA [auth 2A],
JY [auth 1A],
JYA [auth 2A],
JZ [auth 1A],
JZA [auth 2A],
KAA [auth 1A],
KAB [auth 2A],
KBA [auth 1A],
KBB [auth 2A],
KCA [auth 1A],
KCB [auth 2A],
KD [auth 1A],
KDA [auth 1A],
KDB [auth 2A],
KE [auth 1A],
KEA [auth 1A],
KEB [auth 2A],
KF [auth 1A],
KFA [auth 1A],
KFB [auth 2A],
KG [auth 1A],
KGA [auth 1A],
KGB [auth 2A],
KH [auth 1A],
KHA [auth 1B],
KHB [auth 2A],
KI [auth 1A],
KIA [auth 1N],
KIB [auth 2A],
KJ [auth 1A],
KJA [auth 10],
KJB [auth 2A],
KK [auth 1A],
KKA [auth 1a],
KKB [auth 2A],
KL [auth 1A],
KLA [auth 1a],
KLB [auth 2E],
KM [auth 1A],
KMA [auth 1a],
KMB [auth 28],
KN [auth 1A],
KNA [auth 1a],
KNB [auth 2a],
KO [auth 1A],
KOA [auth 1a],
KOB [auth 2a],
KP [auth 1A],
KPA [auth 1a],
KPB [auth 2a],
KQ [auth 1A],
KQA [auth 1q],
KQB [auth 2a],
KR [auth 1A],
KRA [auth 2A],
KRB [auth 2a],
KS [auth 1A],
KSA [auth 2A],
KT [auth 1A],
KTA [auth 2A],
KU [auth 1A],
KUA [auth 2A],
KV [auth 1A],
KVA [auth 2A],
KW [auth 1A],
KWA [auth 2A],
KX [auth 1A],
KXA [auth 2A],
KY [auth 1A],
KYA [auth 2A],
KZ [auth 1A],
KZA [auth 2A],
LAA [auth 1A],
LAB [auth 2A],
LBA [auth 1A],
LBB [auth 2A],
LCA [auth 1A],
LCB [auth 2A],
LD [auth 1A],
LDA [auth 1A],
LDB [auth 2A],
LE [auth 1A],
LEA [auth 1A],
LEB [auth 2A],
LF [auth 1A],
LFA [auth 1A],
LFB [auth 2A],
LG [auth 1A],
LGA [auth 1A],
LGB [auth 2A],
LH [auth 1A],
LHA [auth 1B],
LHB [auth 2A],
LI [auth 1A],
LIA [auth 1P],
LIB [auth 2A],
LJ [auth 1A],
LJA [auth 10],
LJB [auth 2A],
LK [auth 1A],
LKA [auth 1a],
LKB [auth 2B],
LL [auth 1A],
LLA [auth 1a],
LLB [auth 2E],
LM [auth 1A],
LMA [auth 1a],
LMB [auth 28],
LN [auth 1A],
LNA [auth 1a],
LNB [auth 2a],
LO [auth 1A],
LOA [auth 1a],
LOB [auth 2a],
LP [auth 1A],
LPA [auth 1a],
LPB [auth 2a],
LQ [auth 1A],
LQA [auth 1r],
LQB [auth 2a],
LR [auth 1A],
LRA [auth 2A],
LS [auth 1A],
LSA [auth 2A],
LT [auth 1A],
LTA [auth 2A],
LU [auth 1A],
LUA [auth 2A],
LV [auth 1A],
LVA [auth 2A],
LW [auth 1A],
LWA [auth 2A],
LX [auth 1A],
LXA [auth 2A],
LY [auth 1A],
LYA [auth 2A],
LZ [auth 1A],
LZA [auth 2A],
MAA [auth 1A],
MAB [auth 2A],
MBA [auth 1A],
MBB [auth 2A],
MCA [auth 1A],
MCB [auth 2A],
MD [auth 1A],
MDA [auth 1A],
MDB [auth 2A],
ME [auth 1A],
MEA [auth 1A],
MEB [auth 2A],
MF [auth 1A],
MFA [auth 1A],
MFB [auth 2A],
MG [auth 1A],
MGA [auth 1A],
MGB [auth 2A],
MH [auth 1A],
MHA [auth 1D],
MHB [auth 2A],
MI [auth 1A],
MIA [auth 1P],
MIB [auth 2A],
MJ [auth 1A],
MJA [auth 10],
MJB [auth 2A],
MK [auth 1A],
MKA [auth 1a],
MKB [auth 2B],
ML [auth 1A],
MLA [auth 1a],
MLB [auth 2E],
MM [auth 1A],
MMA [auth 1a],
MN [auth 1A],
MNA [auth 1a],
MNB [auth 2a],
MO [auth 1A],
MOA [auth 1a],
MOB [auth 2a],
MP [auth 1A],
MPA [auth 1a],
MPB [auth 2a],
MQ [auth 1A],
MQA [auth 1t],
MQB [auth 2a],
MR [auth 1A],
MRA [auth 2A],
MRB [auth 2e],
MS [auth 1A],
MSA [auth 2A],
MT [auth 1A],
MTA [auth 2A],
MU [auth 1A],
MUA [auth 2A],
MV [auth 1A],
MVA [auth 2A],
MW [auth 1A],
MWA [auth 2A],
MX [auth 1A],
MXA [auth 2A],
MY [auth 1A],
MYA [auth 2A],
MZ [auth 1A],
MZA [auth 2A],
NAA [auth 1A],
NAB [auth 2A],
NBA [auth 1A],
NBB [auth 2A],
NCA [auth 1A],
NCB [auth 2A],
ND [auth 1A],
NDA [auth 1A],
NDB [auth 2A],
NE [auth 1A],
NEA [auth 1A],
NEB [auth 2A],
NF [auth 1A],
NFA [auth 1A],
NFB [auth 2A],
NG [auth 1A],
NGA [auth 1A],
NGB [auth 2A],
NH [auth 1A],
NHA [auth 1D],
NHB [auth 2A],
NI [auth 1A],
NIA [auth 1Q],
NIB [auth 2A],
NJ [auth 1A],
NJA [auth 10],
NJB [auth 2A],
NK [auth 1A],
NKA [auth 1a],
NKB [auth 2B],
NL [auth 1A],
NLA [auth 1a],
NLB [auth 2F],
NM [auth 1A],
NMA [auth 1a],
NMB [auth 2a],
NN [auth 1A],
NNA [auth 1a],
NNB [auth 2a],
NO [auth 1A],
NOA [auth 1a],
NOB [auth 2a],
NP [auth 1A],
NPA [auth 1a],
NPB [auth 2a],
NQ [auth 1A],
NQA [auth 2A],
NQB [auth 2a],
NR [auth 1A],
NRA [auth 2A],
NRB [auth 2h],
NS [auth 1A],
NSA [auth 2A],
NT [auth 1A],
NTA [auth 2A],
NU [auth 1A],
NUA [auth 2A],
NV [auth 1A],
NVA [auth 2A],
NW [auth 1A],
NWA [auth 2A],
NX [auth 1A],
NXA [auth 2A],
NY [auth 1A],
NYA [auth 2A],
NZ [auth 1A],
NZA [auth 2A],
OAA [auth 1A],
OAB [auth 2A],
OBA [auth 1A],
OBB [auth 2A],
OCA [auth 1A],
OCB [auth 2A],
OD [auth 1A],
ODA [auth 1A],
ODB [auth 2A],
OE [auth 1A],
OEA [auth 1A],
OEB [auth 2A],
OF [auth 1A],
OFA [auth 1A],
OFB [auth 2A],
OG [auth 1A],
OGA [auth 1A],
OGB [auth 2A],
OH [auth 1A],
OHA [auth 1D],
OHB [auth 2A],
OI [auth 1A],
OIA [auth 1Q],
OIB [auth 2A],
OJ [auth 1A],
OJA [auth 10],
OJB [auth 2A],
OK [auth 1A],
OKA [auth 1a],
OKB [auth 2B],
OL [auth 1A],
OLA [auth 1a],
OLB [auth 2F],
OM [auth 1A],
OMA [auth 1a],
OMB [auth 2a],
ON [auth 1A],
ONA [auth 1a],
ONB [auth 2a],
OO [auth 1A],
OOA [auth 1a],
OOB [auth 2a],
OP [auth 1A],
OPA [auth 1a],
OPB [auth 2a],
OQ [auth 1A],
OQA [auth 2A],
OQB [auth 2a],
OR [auth 1A],
ORA [auth 2A],
ORB [auth 2k],
OS [auth 1A],
OSA [auth 2A],
OT [auth 1A],
OTA [auth 2A],
OU [auth 1A],
OUA [auth 2A],
OV [auth 1A],
OVA [auth 2A],
OW [auth 1A],
OWA [auth 2A],
OX [auth 1A],
OXA [auth 2A],
OY [auth 1A],
OYA [auth 2A],
OZ [auth 1A],
OZA [auth 2A],
PAA [auth 1A],
PAB [auth 2A],
PBA [auth 1A],
PBB [auth 2A],
PCA [auth 1A],
PCB [auth 2A],
PD [auth 1A],
PDA [auth 1A],
PDB [auth 2A],
PE [auth 1A],
PEA [auth 1A],
PEB [auth 2A],
PF [auth 1A],
PFA [auth 1A],
PFB [auth 2A],
PG [auth 1A],
PGA [auth 1B],
PGB [auth 2A],
PH [auth 1A],
PHA [auth 1D],
PHB [auth 2A],
PI [auth 1A],
PIA [auth 1Q],
PIB [auth 2A],
PJ [auth 1A],
PJA [auth 11],
PJB [auth 2A],
PK [auth 1A],
PKA [auth 1a],
PKB [auth 2B],
PL [auth 1A],
PLA [auth 1a],
PLB [auth 2I],
PM [auth 1A],
PMA [auth 1a],
PMB [auth 2a],
PN [auth 1A],
PNA [auth 1a],
PNB [auth 2a],
PO [auth 1A],
POA [auth 1a],
POB [auth 2a],
PP [auth 1A],
PPA [auth 1a],
PPB [auth 2a],
PQ [auth 1A],
PQA [auth 2A],
PQB [auth 2a],
PR [auth 1A],
PRA [auth 2A],
PRB [auth 2l],
PS [auth 1A],
PSA [auth 2A],
PT [auth 1A],
PTA [auth 2A],
PU [auth 1A],
PUA [auth 2A],
PV [auth 1A],
PVA [auth 2A],
PW [auth 1A],
PWA [auth 2A],
PX [auth 1A],
PXA [auth 2A],
PY [auth 1A],
PYA [auth 2A],
PZ [auth 1A],
PZA [auth 2A],
QAA [auth 1A],
QAB [auth 2A],
QBA [auth 1A],
QBB [auth 2A],
QCA [auth 1A],
QCB [auth 2A],
QD [auth 1A],
QDA [auth 1A],
QDB [auth 2A],
QE [auth 1A],
QEA [auth 1A],
QEB [auth 2A],
QF [auth 1A],
QFA [auth 1A],
QFB [auth 2A],
QG [auth 1A],
QGA [auth 1B],
QGB [auth 2A],
QH [auth 1A],
QHA [auth 1D],
QHB [auth 2A],
QI [auth 1A],
QIA [auth 1R],
QIB [auth 2A],
QJ [auth 1A],
QJA [auth 11],
QJB [auth 2A],
QK [auth 1A],
QKA [auth 1a],
QKB [auth 2B],
QL [auth 1A],
QLA [auth 1a],
QLB [auth 2N],
QM [auth 1A],
QMA [auth 1a],
QMB [auth 2a],
QN [auth 1A],
QNA [auth 1a],
QNB [auth 2a],
QO [auth 1A],
QOA [auth 1a],
QOB [auth 2a],
QP [auth 1A],
QPA [auth 1a],
QPB [auth 2a],
QQ [auth 1A],
QQA [auth 2A],
QQB [auth 2a],
QR [auth 1A],
QRA [auth 2A],
QS [auth 1A],
QSA [auth 2A],
QT [auth 1A],
QTA [auth 2A],
QU [auth 1A],
QUA [auth 2A],
QV [auth 1A],
QVA [auth 2A],
QW [auth 1A],
QWA [auth 2A],
QX [auth 1A],
QXA [auth 2A],
QY [auth 1A],
QYA [auth 2A],
QZ [auth 1A],
QZA [auth 2A],
RAA [auth 1A],
RAB [auth 2A],
RBA [auth 1A],
RBB [auth 2A],
RCA [auth 1A],
RCB [auth 2A],
RD [auth 1A],
RDA [auth 1A],
RDB [auth 2A],
RE [auth 1A],
REA [auth 1A],
REB [auth 2A],
RF [auth 1A],
RFA [auth 1A],
RFB [auth 2A],
RG [auth 1A],
RGA [auth 1B],
RGB [auth 2A],
RH [auth 1A],
RHA [auth 1D],
RHB [auth 2A],
RI [auth 1A],
RIA [auth 1R],
RIB [auth 2A],
RJ [auth 1A],
RJA [auth 13],
RJB [auth 2A],
RK [auth 1A],
RKA [auth 1a],
RKB [auth 2B],
RL [auth 1A],
RLA [auth 1a],
RLB [auth 2O],
RM [auth 1A],
RMA [auth 1a],
RMB [auth 2a],
RN [auth 1A],
RNA [auth 1a],
RNB [auth 2a],
RO [auth 1A],
ROA [auth 1a],
ROB [auth 2a],
RP [auth 1A],
RPA [auth 1a],
RPB [auth 2a],
RQ [auth 1A],
RQA [auth 2A],
RQB [auth 2a],
RR [auth 1A],
RRA [auth 2A],
RRB [auth 2t],
RS [auth 1A],
RSA [auth 2A],
RT [auth 1A],
RTA [auth 2A],
RU [auth 1A],
RUA [auth 2A],
RV [auth 1A],
RVA [auth 2A],
RW [auth 1A],
RWA [auth 2A],
RX [auth 1A],
RXA [auth 2A],
RY [auth 1A],
RYA [auth 2A],
RZ [auth 1A],
RZA [auth 2A],
SAA [auth 1A],
SAB [auth 2A],
SBA [auth 1A],
SBB [auth 2A],
SCA [auth 1A],
SCB [auth 2A],
SD [auth 1A],
SDA [auth 1A],
SDB [auth 2A],
SE [auth 1A],
SEA [auth 1A],
SEB [auth 2A],
SF [auth 1A],
SFA [auth 1A],
SFB [auth 2A],
SG [auth 1A],
SGA [auth 1B],
SGB [auth 2A],
SH [auth 1A],
SHA [auth 1D],
SHB [auth 2A],
SI [auth 1A],
SIA [auth 1R],
SIB [auth 2A],
SJ [auth 1A],
SJB [auth 2A],
SK [auth 1A],
SKA [auth 1a],
SKB [auth 2B],
SL [auth 1A],
SLA [auth 1a],
SLB [auth 2O],
SM [auth 1A],
SMA [auth 1a],
SMB [auth 2a],
SN [auth 1A],
SNA [auth 1a],
SNB [auth 2a],
SO [auth 1A],
SOA [auth 1a],
SOB [auth 2a],
SP [auth 1A],
SPA [auth 1a],
SPB [auth 2a],
SQ [auth 1A],
SQA [auth 2A],
SQB [auth 2a],
SR [auth 1A],
SRA [auth 2A],
SS [auth 1A],
SSA [auth 2A],
ST [auth 1A],
STA [auth 2A],
SU [auth 1A],
SUA [auth 2A],
SV [auth 1A],
SVA [auth 2A],
SW [auth 1A],
SWA [auth 2A],
SX [auth 1A],
SXA [auth 2A],
SY [auth 1A],
SYA [auth 2A],
SZ [auth 1A],
SZA [auth 2A],
TAA [auth 1A],
TAB [auth 2A],
TBA [auth 1A],
TBB [auth 2A],
TCA [auth 1A],
TCB [auth 2A],
TD [auth 1A],
TDA [auth 1A],
TDB [auth 2A],
TE [auth 1A],
TEA [auth 1A],
TEB [auth 2A],
TF [auth 1A],
TFA [auth 1A],
TFB [auth 2A],
TG [auth 1A],
TGA [auth 1B],
TGB [auth 2A],
TH [auth 1A],
THA [auth 1E],
THB [auth 2A],
TI [auth 1A],
TIA [auth 1R],
TIB [auth 2A],
TJ [auth 1A],
TJA [auth 15],
TJB [auth 2A],
TK [auth 1A],
TKA [auth 1a],
TKB [auth 2B],
TL [auth 1A],
TLA [auth 1a],
TLB [auth 2P],
TM [auth 1A],
TMA [auth 1a],
TMB [auth 2a],
TN [auth 1A],
TNA [auth 1a],
TNB [auth 2a],
TO [auth 1A],
TOA [auth 1a],
TOB [auth 2a],
TP [auth 1A],
TPA [auth 1a],
TPB [auth 2a],
TQ [auth 1A],
TQA [auth 2A],
TQB [auth 2a],
TR [auth 1A],
TRA [auth 2A],
TS [auth 1A],
TSA [auth 2A],
TT [auth 1A],
TTA [auth 2A],
TU [auth 1A],
TUA [auth 2A],
TV [auth 1A],
TVA [auth 2A],
TW [auth 1A],
TWA [auth 2A],
TX [auth 1A],
TXA [auth 2A],
TY [auth 1A],
TYA [auth 2A],
TZ [auth 1A],
TZA [auth 2A],
UAA [auth 1A],
UAB [auth 2A],
UBA [auth 1A],
UBB [auth 2A],
UCA [auth 1A],
UCB [auth 2A],
UD [auth 1A],
UDA [auth 1A],
UDB [auth 2A],
UE [auth 1A],
UEA [auth 1A],
UEB [auth 2A],
UF [auth 1A],
UFB [auth 2A],
UG [auth 1A],
UGA [auth 1B],
UGB [auth 2A],
UH [auth 1A],
UHA [auth 1E],
UHB [auth 2A],
UI [auth 1A],
UIA [auth 1R],
UIB [auth 2A],
UJ [auth 1A],
UJA [auth 15],
UJB [auth 2A],
UK [auth 1A],
UKA [auth 1a],
UKB [auth 2B],
UL [auth 1A],
ULA [auth 1a],
ULB [auth 2Q],
UM [auth 1A],
UMA [auth 1a],
UMB [auth 2a],
UN [auth 1A],
UNA [auth 1a],
UNB [auth 2a],
UO [auth 1A],
UOA [auth 1a],
UOB [auth 2a],
UP [auth 1A],
UPA [auth 1a],
UPB [auth 2a],
UQ [auth 1A],
UQA [auth 2A],
UQB [auth 2a],
UR [auth 1A],
URA [auth 2A],
US [auth 1A],
USA [auth 2A],
UT [auth 1A],
UTA [auth 2A],
UU [auth 1A],
UUA [auth 2A],
UV [auth 1A],
UVA [auth 2A],
UW [auth 1A],
UWA [auth 2A],
UX [auth 1A],
UXA [auth 2A],
UY [auth 1A],
UYA [auth 2A],
UZ [auth 1A],
UZA [auth 2A],
VAA [auth 1A],
VAB [auth 2A],
VBA [auth 1A],
VBB [auth 2A],
VCA [auth 1A],
VCB [auth 2A],
VD [auth 1A],
VDA [auth 1A],
VDB [auth 2A],
VE [auth 1A],
VEA [auth 1A],
VEB [auth 2A],
VF [auth 1A],
VFA [auth 1A],
VFB [auth 2A],
VG [auth 1A],
VGA [auth 1B],
VGB [auth 2A],
VH [auth 1A],
VHA [auth 1E],
VHB [auth 2A],
VI [auth 1A],
VIA [auth 1T],
VIB [auth 2A],
VJ [auth 1A],
VJB [auth 2A],
VK [auth 1A],
VKA [auth 1a],
VKB [auth 2B],
VL [auth 1A],
VLA [auth 1a],
VLB [auth 2Q],
VM [auth 1A],
VMA [auth 1a],
VMB [auth 2a],
VN [auth 1A],
VNA [auth 1a],
VNB [auth 2a],
VO [auth 1A],
VOA [auth 1a],
VOB [auth 2a],
VP [auth 1A],
VPA [auth 1b],
VPB [auth 2a],
VQ [auth 1A],
VQA [auth 2A],
VQB [auth 2a],
VR [auth 1A],
VRA [auth 2A],
VS [auth 1A],
VSA [auth 2A],
VT [auth 1A],
VTA [auth 2A],
VU [auth 1A],
VUA [auth 2A],
VV [auth 1A],
VVA [auth 2A],
VW [auth 1A],
VWA [auth 2A],
VX [auth 1A],
VXA [auth 2A],
VY [auth 1A],
VYA [auth 2A],
VZ [auth 1A],
VZA [auth 2A],
WAA [auth 1A],
WAB [auth 2A],
WBA [auth 1A],
WBB [auth 2A],
WCA [auth 1A],
WCB [auth 2A],
WD [auth 1A],
WDA [auth 1A],
WDB [auth 2A],
WE [auth 1A],
WEA [auth 1A],
WEB [auth 2A],
WF [auth 1A],
WFA [auth 1A],
WFB [auth 2A],
WG [auth 1A],
WGA [auth 1B],
WGB [auth 2A],
WH [auth 1A],
WHA [auth 1E],
WHB [auth 2A],
WI [auth 1A],
WIA [auth 1T],
WIB [auth 2A],
WJ [auth 1A],
WJA [auth 15],
WJB [auth 2A],
WK [auth 1A],
WKA [auth 1a],
WKB [auth 2B],
WL [auth 1A],
WLA [auth 1a],
WLB [auth 2Q],
WM [auth 1A],
WMA [auth 1a],
WMB [auth 2a],
WN [auth 1A],
WNA [auth 1a],
WNB [auth 2a],
WO [auth 1A],
WOA [auth 1a],
WOB [auth 2a],
WP [auth 1A],
WPB [auth 2a],
WQ [auth 1A],
WQA [auth 2A],
WQB [auth 2a],
WR [auth 1A],
WRA [auth 2A],
WS [auth 1A],
WSA [auth 2A],
WT [auth 1A],
WTA [auth 2A],
WU [auth 1A],
WUA [auth 2A],
WV [auth 1A],
WVA [auth 2A],
WW [auth 1A],
WWA [auth 2A],
WX [auth 1A],
WXA [auth 2A],
WY [auth 1A],
WYA [auth 2A],
WZ [auth 1A],
WZA [auth 2A],
XAA [auth 1A],
XAB [auth 2A],
XBA [auth 1A],
XBB [auth 2A],
XCA [auth 1A],
XCB [auth 2A],
XD [auth 1A],
XDA [auth 1A],
XDB [auth 2A],
XE [auth 1A],
XEA [auth 1A],
XEB [auth 2A],
XF [auth 1A],
XFA [auth 1A],
XFB [auth 2A],
XG [auth 1A],
XGA [auth 1B],
XGB [auth 2A],
XH [auth 1A],
XHA [auth 1E],
XHB [auth 2A],
XI [auth 1A],
XIA [auth 1T],
XIB [auth 2A],
XJ [auth 1A],
XJA [auth 15],
XJB [auth 2A],
XK [auth 1A],
XKA [auth 1a],
XKB [auth 2B],
XL [auth 1A],
XLA [auth 1a],
XLB [auth 2R],
XM [auth 1A],
XMA [auth 1a],
XMB [auth 2a],
XN [auth 1A],
XNA [auth 1a],
XNB [auth 2a],
XO [auth 1A],
XOA [auth 1a],
XOB [auth 2a],
XP [auth 1A],
XPA [auth 1d],
XPB [auth 2a],
XQ [auth 1A],
XQA [auth 2A],
XQB [auth 2a],
XR [auth 1A],
XRA [auth 2A],
XS [auth 1A],
XSA [auth 2A],
XT [auth 1A],
XTA [auth 2A],
XU [auth 1A],
XUA [auth 2A],
XV [auth 1A],
XVA [auth 2A],
XW [auth 1A],
XWA [auth 2A],
XX [auth 1A],
XXA [auth 2A],
XY [auth 1A],
XYA [auth 2A],
XZ [auth 1A],
XZA [auth 2A],
YAA [auth 1A],
YAB [auth 2A],
YBA [auth 1A],
YBB [auth 2A],
YCA [auth 1A],
YCB [auth 2A],
YD [auth 1A],
YDA [auth 1A],
YDB [auth 2A],
YE [auth 1A],
YEA [auth 1A],
YEB [auth 2A],
YF [auth 1A],
YFA [auth 1A],
YFB [auth 2A],
YG [auth 1A],
YGA [auth 1B],
YGB [auth 2A],
YH [auth 1A],
YHA [auth 1E],
YHB [auth 2A],
YI [auth 1A],
YIA [auth 1T],
YIB [auth 2A],
YJ [auth 1A],
YJA [auth 15],
YJB [auth 2A],
YK [auth 1A],
YKA [auth 1a],
YKB [auth 2B],
YL [auth 1A],
YLA [auth 1a],
YLB [auth 2T],
YM [auth 1A],
YMA [auth 1a],
YMB [auth 2a],
YN [auth 1A],
YNA [auth 1a],
YNB [auth 2a],
YO [auth 1A],
YOA [auth 1a],
YOB [auth 2a],
YP [auth 1A],
YPA [auth 1d],
YPB [auth 2a],
YQ [auth 1A],
YQA [auth 2A],
YQB [auth 2a],
YR [auth 1A],
YRA [auth 2A],
YS [auth 1A],
YSA [auth 2A],
YT [auth 1A],
YTA [auth 2A],
YU [auth 1A],
YUA [auth 2A],
YV [auth 1A],
YVA [auth 2A],
YW [auth 1A],
YWA [auth 2A],
YX [auth 1A],
YXA [auth 2A],
YY [auth 1A],
YYA [auth 2A],
YZ [auth 1A],
YZA [auth 2A],
ZAA [auth 1A],
ZAB [auth 2A],
ZBA [auth 1A],
ZBB [auth 2A],
ZCA [auth 1A],
ZCB [auth 2A],
ZD [auth 1A],
ZDA [auth 1A],
ZDB [auth 2A],
ZE [auth 1A],
ZEA [auth 1A],
ZEB [auth 2A],
ZF [auth 1A],
ZFA [auth 1A],
ZFB [auth 2A],
ZG [auth 1A],
ZGA [auth 1B],
ZGB [auth 2A],
ZH [auth 1A],
ZHA [auth 1F],
ZHB [auth 2A],
ZI [auth 1A],
ZIA [auth 1U],
ZIB [auth 2A],
ZJ [auth 1A],
ZJB [auth 2A],
ZK [auth 1A],
ZKA [auth 1a],
ZKB [auth 2B],
ZL [auth 1A],
ZLA [auth 1a],
ZLB [auth 2T],
ZM [auth 1A],
ZMA [auth 1a],
ZMB [auth 2a],
ZN [auth 1A],
ZNA [auth 1a],
ZNB [auth 2a],
ZO [auth 1A],
ZOA [auth 1a],
ZOB [auth 2a],
ZP [auth 1A],
ZPA [auth 1e],
ZPB [auth 2a],
ZQ [auth 1A],
ZQA [auth 2A],
ZQB [auth 2a],
ZR [auth 1A],
ZRA [auth 2A],
ZS [auth 1A],
ZSA [auth 2A],
ZT [auth 1A],
ZTA [auth 2A],
ZU [auth 1A],
ZUA [auth 2A],
ZV [auth 1A],
ZVA [auth 2A],
ZW [auth 1A],
ZWA [auth 2A],
ZX [auth 1A],
ZXA [auth 2A],
ZY [auth 1A],
ZYA [auth 2A],
ZZ [auth 1A],
ZZA [auth 2A]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Modified Residues  1 Unique
IDChains TypeFormula2D DiagramParent
0TD
Query on 0TD		QA [auth 1l],
QC [auth 2l]		L-PEPTIDE LINKINGC5 H9 N O4 SASP
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.10 Å
  • R-Value Free: 0.284 
  • R-Value Work: 0.232 
  • R-Value Observed: 0.235 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 209.51α = 90
b = 448.29β = 90
c = 619.37γ = 90
Software Package:
Software NamePurpose
PHENIXrefinement
XDSdata reduction
XSCALEdata scaling
PHASERphasing
Cootmodel building
PDB_EXTRACTdata extraction

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


View more in-depth experimental data
Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesGM022778
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesGM095737
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesGM079238
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesGM098859
German Research Foundation (DFG)GermanyFOR1805
German Research Foundation (DFG)GermanyWI3285/3-1
German Research Foundation (DFG)GermanyGRK1721

Revision History  (Full details and data files)

  • Version 1.0: 2015-12-30
    Type: Initial release
  • Version 1.1: 2016-09-14
    Changes: Derived calculations
  • Version 1.2: 2017-09-20
    Changes: Author supporting evidence, Derived calculations
  • Version 1.3: 2017-09-27
    Changes: Author supporting evidence
  • Version 1.4: 2019-12-25
    Changes: Author supporting evidence, Derived calculations
  • Version 1.5: 2023-09-27
    Changes: Data collection, Database references, Derived calculations, Refinement description
  • Version 1.6: 2023-11-15
    Changes: Data collection