5HAU

Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Free: 0.265 
  • R-Value Work: 0.208 
  • R-Value Observed: 0.211 

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This is version 1.4 of the entry. See complete history. 


Literature

Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.

Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.

(2016) Nucleic Acids Res 44: 2439-2450

  • DOI: https://doi.org/10.1093/nar/gkw018
  • Primary Citation of Related Structures:  
    5HAU, 5HCP, 5HCQ, 5HCR, 5HD1

  • PubMed Abstract: 

    With bacterial resistance becoming a serious threat to global public health, antimicrobial peptides (AMPs) have become a promising area of focus in antibiotic research. AMPs are derived from a diverse range of species, from prokaryotes to humans, with a mechanism of action that often involves disruption of the bacterial cell membrane. Proline-rich antimicrobial peptides (PrAMPs) are instead actively transported inside the bacterial cell where they bind and inactivate specific targets. Recently, it was reported that some PrAMPs, such as Bac71 -35, oncocins and apidaecins, bind and inactivate the bacterial ribosome. Here we report the crystal structures of Bac71 -35, Pyrrhocoricin, Metalnikowin and two oncocin derivatives, bound to the Thermus thermophilus 70S ribosome. Each of the PrAMPs blocks the peptide exit tunnel of the ribosome by simultaneously occupying three well characterized antibiotic-binding sites and interferes with the initiation step of translation, thereby revealing a common mechanism of action used by these PrAMPs to inactivate protein synthesis. Our study expands the repertoire of PrAMPs and provides a framework for designing new-generation therapeutics.

    • Organizational Affiliation: 

    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA Howard Hughes Medical Institute, Yale University, New Haven, CT 06520-8114, USA [email protected].


Macromolecules

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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L1C [auth 1C],
IB [auth 2C]		229Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L2D [auth 1D],
JB [auth 2D]		276Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L3E [auth 1E],
KB [auth 2E]		206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L4F [auth 1F],
LB [auth 2F]		210Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L5G [auth 1G],
MB [auth 2G]		182Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L6H [auth 1H],
NB [auth 2H]		180Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L10I [auth 1J],
OB [auth 2J]		173Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L11J [auth 1K],
PB [auth 2K]		147Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L13K [auth 1L],
QB [auth 2L]		140Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L14L [auth 1M],
RB [auth 2M]		122Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L15M [auth 1N],
SB [auth 2N]		150Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L16N [auth 1O],
TB [auth 2O]		141Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L17O [auth 1P],
UB [auth 2P]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L18P [auth 1Q],
VB [auth 2Q]		112Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L19Q [auth 1R],
WB [auth 2R]		146Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L20R [auth 1S],
XB [auth 2S]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L21S [auth 1T],
YB [auth 2T]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L22T [auth 1U],
ZB [auth 2U]		113Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L23AC [auth 2V],
U [auth 1V]		96Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 22
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L24BC [auth 2W],
V [auth 1W]		110Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 23
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L25CC [auth 2X],
W [auth 1X]		206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L27DC [auth 2Y],
X [auth 1Y]		85Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 25
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L28EC [auth 2Z],
Y [auth 1Z]		98Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L29FC [auth 20],
Z [auth 10]		72Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L30AA [auth 11],
GC [auth 21]		60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L31BA [auth 12],
HC [auth 22]		71Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L32CA [auth 13],
IC [auth 23]		60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L33DA [auth 14],
JC [auth 24]		54Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 31
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L34EA [auth 15],
KC [auth 25]		49Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 32
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L35FA [auth 16],
LC [auth 26]		65Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L36GA [auth 17],
MC [auth 27]		37Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S2IA [auth 1b],
OC [auth 2b]		256Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S3JA [auth 1c],
PC [auth 2c]		239Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S4KA [auth 1d],
QC [auth 2d]		209Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S5LA [auth 1e],
RC [auth 2e]		162Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S6MA [auth 1f],
SC [auth 2f]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S7NA [auth 1g],
TC [auth 2g]		156Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S8OA [auth 1h],
UC [auth 2h]		138Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S9PA [auth 1i],
VC [auth 2i]		128Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S10QA [auth 1j],
WC [auth 2j]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S11RA [auth 1k],
XC [auth 2k]		129Thermus thermophilus HB8Mutation(s): 0 
UniProt
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UniProt GroupP80376
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S12SA [auth 1l],
YC [auth 2l]		132Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S13TA [auth 1m],
ZC [auth 2m]		126Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S14 type ZAD [auth 2n],
UA [auth 1n]		61Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S15BD [auth 2o],
VA [auth 1o]		89Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S16CD [auth 2p],
WA [auth 1p]		88Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S17DD [auth 2q],
XA [auth 1q]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S18ED [auth 2r],
YA [auth 1r]		88Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S19FD [auth 2s],
ZA [auth 1s]		93Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 53
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S20AB [auth 1t],
GD [auth 2t]		106Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 54
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein ThxBB [auth 1u],
HD [auth 2u]		27Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 55
MoleculeChains Sequence LengthOrganismDetailsImage
Chimera protein of 50S ribosomal protein L9 and Elongation factor GCB [auth 1z],
ID [auth 2z]		758Thermus thermophilus HB8Mutation(s): 0 
Gene Names: rplI, TTHA0242, fusA, fus, TTHA1695
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Find proteins for Q5SHN5 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 58
MoleculeChains Sequence LengthOrganismDetailsImage
Cathelicidin-3FB [auth 1x],
LD [auth 2x]		35Bos taurusMutation(s): 0 
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Entity ID: 1
MoleculeChains LengthOrganismImage
23S Ribosomal RNAA [auth 1A],
GB [auth 2A]		2,915Thermus thermophilus HB8
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Entity ID: 2
MoleculeChains LengthOrganismImage
5S Ribosomal RNAB [auth 1B],
HB [auth 2B]		121Thermus thermophilus HB8
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Entity ID: 34
MoleculeChains LengthOrganismImage
16S Ribosomal RNAHA [auth 1a],
NC [auth 2a]		1,521Thermus thermophilus HB8
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Entity ID: 56
MoleculeChains LengthOrganismImage
mRNADB [auth 1y],
JD [auth 2y]		24Tequatrovirus T4
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Entity ID: 57
MoleculeChains LengthOrganismImage
P-site tRNAEB [auth 1w],
KD [auth 2w]		77Escherichia coli
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Small Molecules
Ligands 4 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
GDP
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BTA [auth 1z],
ZZB [auth 2z]		GUANOSINE-5'-DIPHOSPHATE
C10 H15 N5 O11 P2
QGWNDRXFNXRZMB-UUOKFMHZSA-N
SF4
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OZB [auth 2d],
SSA [auth 1d]		IRON/SULFUR CLUSTER
Fe4 S4
LJBDFODJNLIPKO-UHFFFAOYSA-N
ZN
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HKA [auth 12]
KKA [auth 13]
NKA [auth 14]
NSB [auth 2W]
QSB [auth 22]
HKA [auth 12],
KKA [auth 13],
NKA [auth 14],
NSB [auth 2W],
QSB [auth 22],
RSB [auth 23],
TKA [auth 17],
TSB [auth 24],
UZB [auth 2n],
WJA [auth 1W],
WSB [auth 27],
ZSA [auth 1n]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
MG
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AAA [auth 1A]
AAB [auth 2A]
AAC [auth 2z]
ABA [auth 1A]
ABB [auth 2A]
AAA [auth 1A],
AAB [auth 2A],
AAC [auth 2z],
ABA [auth 1A],
ABB [auth 2A],
ACA [auth 1A],
ACB [auth 2A],
ADA [auth 1A],
ADB [auth 2A],
AE [auth 1A],
AEA [auth 1A],
AEB [auth 2A],
AF [auth 1A],
AFA [auth 1A],
AFB [auth 2A],
AG [auth 1A],
AGA [auth 1A],
AGB [auth 2A],
AH [auth 1A],
AHA [auth 1A],
AHB [auth 2A],
AI [auth 1A],
AIA [auth 1B],
AIB [auth 2A],
AJ [auth 1A],
AJA [auth 1F],
AJB [auth 2A],
AK [auth 1A],
AKA [auth 1Y],
AKB [auth 2A],
AL [auth 1A],
ALA [auth 1a],
ALB [auth 2A],
AM [auth 1A],
AMA [auth 1a],
AMB [auth 2A],
AN [auth 1A],
ANA [auth 1a],
ANB [auth 2A],
AO [auth 1A],
AOA [auth 1a],
AOB [auth 2A],
AP [auth 1A],
APA [auth 1a],
APB [auth 2A],
AQ [auth 1A],
AQA [auth 1a],
AQB [auth 2A],
AR [auth 1A],
ARA [auth 1a],
ARB [auth 2A],
AS [auth 1A],
ASA [auth 1a],
ASB [auth 2F],
AT [auth 1A],
ATA [auth 1t],
ATB [auth 2a],
AU [auth 1A],
AUA [auth 2A],
AUB [auth 2a],
AV [auth 1A],
AVA [auth 2A],
AVB [auth 2a],
AW [auth 1A],
AWA [auth 2A],
AWB [auth 2a],
AX [auth 1A],
AXA [auth 2A],
AXB [auth 2a],
AY [auth 1A],
AYA [auth 2A],
AYB [auth 2a],
AZ [auth 1A],
AZA [auth 2A],
AZB [auth 2a],
BAA [auth 1A],
BAB [auth 2A],
BAC [auth 2z],
BBA [auth 1A],
BBB [auth 2A],
BCA [auth 1A],
BCB [auth 2A],
BDA [auth 1A],
BDB [auth 2A],
BE [auth 1A],
BEA [auth 1A],
BEB [auth 2A],
BF [auth 1A],
BFA [auth 1A],
BFB [auth 2A],
BG [auth 1A],
BGA [auth 1A],
BGB [auth 2A],
BH [auth 1A],
BHA [auth 1A],
BHB [auth 2A],
BI [auth 1A],
BIA [auth 1B],
BIB [auth 2A],
BJ [auth 1A],
BJA [auth 1G],
BJB [auth 2A],
BK [auth 1A],
BKA [auth 1Y],
BKB [auth 2A],
BL [auth 1A],
BLA [auth 1a],
BLB [auth 2A],
BM [auth 1A],
BMA [auth 1a],
BMB [auth 2A],
BN [auth 1A],
BNA [auth 1a],
BNB [auth 2A],
BO [auth 1A],
BOA [auth 1a],
BOB [auth 2A],
BP [auth 1A],
BPA [auth 1a],
BPB [auth 2A],
BQ [auth 1A],
BQA [auth 1a],
BQB [auth 2A],
BR [auth 1A],
BRA [auth 1a],
BRB [auth 2A],
BS [auth 1A],
BSA [auth 1a],
BSB [auth 2F],
BT [auth 1A],
BTB [auth 2a],
BU [auth 1A],
BUA [auth 2A],
BUB [auth 2a],
BV [auth 1A],
BVA [auth 2A],
BVB [auth 2a],
BW [auth 1A],
BWA [auth 2A],
BWB [auth 2a],
BX [auth 1A],
BXA [auth 2A],
BXB [auth 2a],
BY [auth 1A],
BYA [auth 2A],
BYB [auth 2a],
BZ [auth 1A],
BZA [auth 2A],
BZB [auth 2a],
CAA [auth 1A],
CAB [auth 2A],
CAC [auth 2z],
CBA [auth 1A],
CBB [auth 2A],
CCA [auth 1A],
CCB [auth 2A],
CDA [auth 1A],
CDB [auth 2A],
CE [auth 1A],
CEA [auth 1A],
CEB [auth 2A],
CF [auth 1A],
CFA [auth 1A],
CFB [auth 2A],
CG [auth 1A],
CGA [auth 1A],
CGB [auth 2A],
CH [auth 1A],
CHA [auth 1A],
CHB [auth 2A],
CI [auth 1A],
CIA [auth 1B],
CIB [auth 2A],
CJ [auth 1A],
CJA [auth 1G],
CJB [auth 2A],
CK [auth 1A],
CKA [auth 1Y],
CKB [auth 2A],
CL [auth 1A],
CLA [auth 1a],
CLB [auth 2A],
CM [auth 1A],
CMA [auth 1a],
CMB [auth 2A],
CN [auth 1A],
CNA [auth 1a],
CNB [auth 2A],
CO [auth 1A],
COA [auth 1a],
COB [auth 2A],
CP [auth 1A],
CPA [auth 1a],
CPB [auth 2A],
CQ [auth 1A],
CQA [auth 1a],
CQB [auth 2A],
CR [auth 1A],
CRA [auth 1a],
CRB [auth 2A],
CS [auth 1A],
CSA [auth 1a],
CSB [auth 2F],
CT [auth 1A],
CTA [auth 1z],
CTB [auth 2a],
CU [auth 1A],
CUA [auth 2A],
CUB [auth 2a],
CV [auth 1A],
CVA [auth 2A],
CVB [auth 2a],
CW [auth 1A],
CWA [auth 2A],
CWB [auth 2a],
CX [auth 1A],
CXA [auth 2A],
CXB [auth 2a],
CY [auth 1A],
CYA [auth 2A],
CYB [auth 2a],
CZ [auth 1A],
CZA [auth 2A],
CZB [auth 2a],
DAA [auth 1A],
DAB [auth 2A],
DAC [auth 2w],
DBA [auth 1A],
DBB [auth 2A],
DCA [auth 1A],
DCB [auth 2A],
DDA [auth 1A],
DDB [auth 2A],
DE [auth 1A],
DEA [auth 1A],
DEB [auth 2A],
DF [auth 1A],
DFA [auth 1A],
DFB [auth 2A],
DG [auth 1A],
DGA [auth 1A],
DGB [auth 2A],
DH [auth 1A],
DHA [auth 1A],
DHB [auth 2A],
DI [auth 1A],
DIA [auth 1B],
DIB [auth 2A],
DJ [auth 1A],
DJA [auth 1H],
DJB [auth 2A],
DK [auth 1A],
DKA [auth 1Y],
DKB [auth 2A],
DL [auth 1A],
DLA [auth 1a],
DLB [auth 2A],
DM [auth 1A],
DMA [auth 1a],
DMB [auth 2A],
DN [auth 1A],
DNA [auth 1a],
DNB [auth 2A],
DO [auth 1A],
DOA [auth 1a],
DOB [auth 2A],
DP [auth 1A],
DPA [auth 1a],
DPB [auth 2A],
DQ [auth 1A],
DQA [auth 1a],
DQB [auth 2A],
DR [auth 1A],
DRA [auth 1a],
DRB [auth 2A],
DS [auth 1A],
DSA [auth 1a],
DSB [auth 2G],
DT [auth 1A],
DTA [auth 1w],
DTB [auth 2a],
DU [auth 1A],
DUA [auth 2A],
DUB [auth 2a],
DV [auth 1A],
DVA [auth 2A],
DVB [auth 2a],
DW [auth 1A],
DWA [auth 2A],
DWB [auth 2a],
DX [auth 1A],
DXA [auth 2A],
DXB [auth 2a],
DY [auth 1A],
DYA [auth 2A],
DYB [auth 2a],
DZ [auth 1A],
DZA [auth 2A],
DZB [auth 2a],
EAA [auth 1A],
EAB [auth 2A],
EAC [auth 2w],
EBA [auth 1A],
EBB [auth 2A],
ECA [auth 1A],
ECB [auth 2A],
EDA [auth 1A],
EDB [auth 2A],
EE [auth 1A],
EEA [auth 1A],
EEB [auth 2A],
EF [auth 1A],
EFA [auth 1A],
EFB [auth 2A],
EG [auth 1A],
EGA [auth 1A],
EGB [auth 2A],
EH [auth 1A],
EHA [auth 1A],
EHB [auth 2A],
EI [auth 1A],
EIA [auth 1B],
EIB [auth 2A],
EJ [auth 1A],
EJA [auth 1L],
EJB [auth 2A],
EK [auth 1A],
EKA [auth 10],
EKB [auth 2A],
EL [auth 1A],
ELA [auth 1a],
ELB [auth 2A],
EM [auth 1A],
EMA [auth 1a],
EMB [auth 2A],
EN [auth 1A],
ENA [auth 1a],
ENB [auth 2A],
EO [auth 1A],
EOA [auth 1a],
EOB [auth 2A],
EP [auth 1A],
EPA [auth 1a],
EPB [auth 2A],
EQ [auth 1A],
EQA [auth 1a],
EQB [auth 2A],
ER [auth 1A],
ERA [auth 1a],
ERB [auth 2A],
ES [auth 1A],
ESA [auth 1a],
ESB [auth 2M],
ET [auth 1A],
ETA [auth 1w],
ETB [auth 2a],
EU [auth 1A],
EUA [auth 2A],
EUB [auth 2a],
EV [auth 1A],
EVA [auth 2A],
EVB [auth 2a],
EW [auth 1A],
EWA [auth 2A],
EWB [auth 2a],
EX [auth 1A],
EXA [auth 2A],
EXB [auth 2a],
EY [auth 1A],
EYA [auth 2A],
EYB [auth 2a],
EZ [auth 1A],
EZA [auth 2A],
EZB [auth 2a],
FAA [auth 1A],
FAB [auth 2A],
FAC [auth 2w],
FBA [auth 1A],
FBB [auth 2A],
FCA [auth 1A],
FCB [auth 2A],
FDA [auth 1A],
FDB [auth 2A],
FE [auth 1A],
FEA [auth 1A],
FEB [auth 2A],
FF [auth 1A],
FFA [auth 1A],
FFB [auth 2A],
FG [auth 1A],
FGA [auth 1A],
FGB [auth 2A],
FH [auth 1A],
FHA [auth 1A],
FHB [auth 2A],
FI [auth 1A],
FIA [auth 1B],
FIB [auth 2A],
FJ [auth 1A],
FJA [auth 1L],
FJB [auth 2A],
FK [auth 1A],
FKA [auth 10],
FKB [auth 2A],
FL [auth 1A],
FLA [auth 1a],
FLB [auth 2A],
FM [auth 1A],
FMA [auth 1a],
FMB [auth 2A],
FN [auth 1A],
FNA [auth 1a],
FNB [auth 2A],
FO [auth 1A],
FOA [auth 1a],
FOB [auth 2A],
FP [auth 1A],
FPA [auth 1a],
FPB [auth 2A],
FQ [auth 1A],
FQA [auth 1a],
FQB [auth 2A],
FR [auth 1A],
FRA [auth 1a],
FRB [auth 2B],
FS [auth 1A],
FSA [auth 1a],
FSB [auth 2M],
FT [auth 1A],
FTA [auth 1w],
FTB [auth 2a],
FU [auth 1A],
FUA [auth 2A],
FUB [auth 2a],
FV [auth 1A],
FVA [auth 2A],
FVB [auth 2a],
FW [auth 1A],
FWA [auth 2A],
FWB [auth 2a],
FX [auth 1A],
FXA [auth 2A],
FXB [auth 2a],
FY [auth 1A],
FYA [auth 2A],
FYB [auth 2a],
FZ [auth 1A],
FZA [auth 2A],
FZB [auth 2a],
GAA [auth 1A],
GAB [auth 2A],
GAC [auth 2w],
GBA [auth 1A],
GBB [auth 2A],
GCA [auth 1A],
GCB [auth 2A],
GDA [auth 1A],
GDB [auth 2A],
GE [auth 1A],
GEA [auth 1A],
GEB [auth 2A],
GF [auth 1A],
GFA [auth 1A],
GFB [auth 2A],
GG [auth 1A],
GGA [auth 1A],
GGB [auth 2A],
GH [auth 1A],
GHA [auth 1A],
GHB [auth 2A],
GI [auth 1A],
GIA [auth 1B],
GIB [auth 2A],
GJ [auth 1A],
GJA [auth 1M],
GJB [auth 2A],
GK [auth 1A],
GKA [auth 11],
GKB [auth 2A],
GL [auth 1A],
GLA [auth 1a],
GLB [auth 2A],
GM [auth 1A],
GMA [auth 1a],
GMB [auth 2A],
GN [auth 1A],
GNA [auth 1a],
GNB [auth 2A],
GO [auth 1A],
GOA [auth 1a],
GOB [auth 2A],
GP [auth 1A],
GPA [auth 1a],
GPB [auth 2A],
GQ [auth 1A],
GQA [auth 1a],
GQB [auth 2A],
GR [auth 1A],
GRA [auth 1a],
GRB [auth 2B],
GS [auth 1A],
GSA [auth 1a],
GSB [auth 2N],
GT [auth 1A],
GTA [auth 1w],
GTB [auth 2a],
GU [auth 1A],
GUA [auth 2A],
GUB [auth 2a],
GV [auth 1A],
GVA [auth 2A],
GVB [auth 2a],
GW [auth 1A],
GWA [auth 2A],
GWB [auth 2a],
GX [auth 1A],
GXA [auth 2A],
GXB [auth 2a],
GY [auth 1A],
GYA [auth 2A],
GYB [auth 2a],
GZ [auth 1A],
GZA [auth 2A],
GZB [auth 2a],
HAA [auth 1A],
HAB [auth 2A],
HBA [auth 1A],
HBB [auth 2A],
HCA [auth 1A],
HCB [auth 2A],
HDA [auth 1A],
HDB [auth 2A],
HE [auth 1A],
HEA [auth 1A],
HEB [auth 2A],
HF [auth 1A],
HFA [auth 1A],
HFB [auth 2A],
HG [auth 1A],
HGA [auth 1A],
HGB [auth 2A],
HH [auth 1A],
HHA [auth 1A],
HHB [auth 2A],
HI [auth 1A],
HIA [auth 1B],
HIB [auth 2A],
HJ [auth 1A],
HJA [auth 1N],
HJB [auth 2A],
HK [auth 1A],
HKB [auth 2A],
HL [auth 1A],
HLA [auth 1a],
HLB [auth 2A],
HM [auth 1A],
HMA [auth 1a],
HMB [auth 2A],
HN [auth 1A],
HNA [auth 1a],
HNB [auth 2A],
HO [auth 1A],
HOA [auth 1a],
HOB [auth 2A],
HP [auth 1A],
HPA [auth 1a],
HPB [auth 2A],
HQ [auth 1A],
HQA [auth 1a],
HQB [auth 2A],
HR [auth 1A],
HRA [auth 1a],
HRB [auth 2B],
HS [auth 1A],
HSA [auth 1a],
HSB [auth 2O],
HT [auth 1A],
HTA [auth 1w],
HTB [auth 2a],
HU [auth 1A],
HUA [auth 2A],
HUB [auth 2a],
HV [auth 1A],
HVA [auth 2A],
HVB [auth 2a],
HW [auth 1A],
HWA [auth 2A],
HWB [auth 2a],
HX [auth 1A],
HXA [auth 2A],
HXB [auth 2a],
HY [auth 1A],
HYA [auth 2A],
HYB [auth 2a],
HZ [auth 1A],
HZA [auth 2A],
HZB [auth 2a],
IAA [auth 1A],
IAB [auth 2A],
IBA [auth 1A],
IBB [auth 2A],
ICA [auth 1A],
ICB [auth 2A],
IDA [auth 1A],
IDB [auth 2A],
IE [auth 1A],
IEA [auth 1A],
IEB [auth 2A],
IF [auth 1A],
IFA [auth 1A],
IFB [auth 2A],
IG [auth 1A],
IGA [auth 1A],
IGB [auth 2A],
IH [auth 1A],
IHA [auth 1A],
IHB [auth 2A],
II [auth 1A],
IIA [auth 1B],
IIB [auth 2A],
IJ [auth 1A],
IJA [auth 1N],
IJB [auth 2A],
IK [auth 1A],
IKA [auth 13],
IKB [auth 2A],
IL [auth 1A],
ILA [auth 1a],
ILB [auth 2A],
IM [auth 1A],
IMA [auth 1a],
IMB [auth 2A],
IN [auth 1A],
INA [auth 1a],
INB [auth 2A],
IO [auth 1A],
IOA [auth 1a],
IOB [auth 2A],
IP [auth 1A],
IPA [auth 1a],
IPB [auth 2A],
IQ [auth 1A],
IQA [auth 1a],
IQB [auth 2A],
IR [auth 1A],
IRA [auth 1a],
IRB [auth 2B],
IS [auth 1A],
ISA [auth 1a],
ISB [auth 2O],
IT [auth 1A],
ITA [auth 1w],
ITB [auth 2a],
IU [auth 1A],
IUA [auth 2A],
IUB [auth 2a],
IV [auth 1A],
IVA [auth 2A],
IVB [auth 2a],
IW [auth 1A],
IWA [auth 2A],
IWB [auth 2a],
IX [auth 1A],
IXA [auth 2A],
IXB [auth 2a],
IY [auth 1A],
IYA [auth 2A],
IYB [auth 2a],
IZ [auth 1A],
IZA [auth 2A],
IZB [auth 2a],
JAA [auth 1A],
JAB [auth 2A],
JBA [auth 1A],
JBB [auth 2A],
JCA [auth 1A],
JCB [auth 2A],
JDA [auth 1A],
JDB [auth 2A],
JE [auth 1A],
JEA [auth 1A],
JEB [auth 2A],
JF [auth 1A],
JFA [auth 1A],
JFB [auth 2A],
JG [auth 1A],
JGA [auth 1A],
JGB [auth 2A],
JH [auth 1A],
JHA [auth 1A],
JHB [auth 2A],
JI [auth 1A],
JIA [auth 1B],
JIB [auth 2A],
JJ [auth 1A],
JJA [auth 1O],
JJB [auth 2A],
JK [auth 1A],
JKA [auth 13],
JKB [auth 2A],
JL [auth 1A],
JLA [auth 1a],
JLB [auth 2A],
JM [auth 1A],
JMA [auth 1a],
JMB [auth 2A],
JN [auth 1A],
JNA [auth 1a],
JNB [auth 2A],
JO [auth 1A],
JOA [auth 1a],
JOB [auth 2A],
JP [auth 1A],
JPA [auth 1a],
JPB [auth 2A],
JQ [auth 1A],
JQA [auth 1a],
JQB [auth 2A],
JR [auth 1A],
JRA [auth 1a],
JRB [auth 2B],
JS [auth 1A],
JSA [auth 1a],
JSB [auth 2P],
JT [auth 1A],
JTA [auth 2A],
JTB [auth 2a],
JU [auth 1A],
JUA [auth 2A],
JUB [auth 2a],
JV [auth 1A],
JVA [auth 2A],
JVB [auth 2a],
JW [auth 1A],
JWA [auth 2A],
JWB [auth 2a],
JX [auth 1A],
JXA [auth 2A],
JXB [auth 2a],
JY [auth 1A],
JYA [auth 2A],
JYB [auth 2a],
JZ [auth 1A],
JZA [auth 2A],
JZB [auth 2a],
KAA [auth 1A],
KAB [auth 2A],
KBA [auth 1A],
KBB [auth 2A],
KCA [auth 1A],
KCB [auth 2A],
KDA [auth 1A],
KDB [auth 2A],
KE [auth 1A],
KEA [auth 1A],
KEB [auth 2A],
KF [auth 1A],
KFA [auth 1A],
KFB [auth 2A],
KG [auth 1A],
KGA [auth 1A],
KGB [auth 2A],
KH [auth 1A],
KHA [auth 1A],
KHB [auth 2A],
KI [auth 1A],
KIA [auth 1D],
KIB [auth 2A],
KJ [auth 1A],
KJA [auth 1O],
KJB [auth 2A],
KK [auth 1A],
KKB [auth 2A],
KL [auth 1A],
KLA [auth 1a],
KLB [auth 2A],
KM [auth 1A],
KMA [auth 1a],
KMB [auth 2A],
KN [auth 1A],
KNA [auth 1a],
KNB [auth 2A],
KO [auth 1A],
KOA [auth 1a],
KOB [auth 2A],
KP [auth 1A],
KPA [auth 1a],
KPB [auth 2A],
KQ [auth 1A],
KQA [auth 1a],
KQB [auth 2A],
KR [auth 1A],
KRA [auth 1a],
KRB [auth 2B],
KS [auth 1A],
KSA [auth 1a],
KSB [auth 2R],
KT [auth 1A],
KTA [auth 2A],
KTB [auth 2a],
KU [auth 1A],
KUA [auth 2A],
KUB [auth 2a],
KV [auth 1A],
KVA [auth 2A],
KVB [auth 2a],
KW [auth 1A],
KWA [auth 2A],
KWB [auth 2a],
KX [auth 1A],
KXA [auth 2A],
KXB [auth 2a],
KY [auth 1A],
KYA [auth 2A],
KYB [auth 2a],
KZ [auth 1A],
KZA [auth 2A],
KZB [auth 2a],
LAA [auth 1A],
LAB [auth 2A],
LBA [auth 1A],
LBB [auth 2A],
LCA [auth 1A],
LCB [auth 2A],
LDA [auth 1A],
LDB [auth 2A],
LE [auth 1A],
LEA [auth 1A],
LEB [auth 2A],
LF [auth 1A],
LFA [auth 1A],
LFB [auth 2A],
LG [auth 1A],
LGA [auth 1A],
LGB [auth 2A],
LH [auth 1A],
LHA [auth 1A],
LHB [auth 2A],
LI [auth 1A],
LIA [auth 1D],
LIB [auth 2A],
LJ [auth 1A],
LJA [auth 1P],
LJB [auth 2A],
LK [auth 1A],
LKA [auth 13],
LKB [auth 2A],
LL [auth 1A],
LLA [auth 1a],
LLB [auth 2A],
LM [auth 1A],
LMA [auth 1a],
LMB [auth 2A],
LN [auth 1A],
LNA [auth 1a],
LNB [auth 2A],
LO [auth 1A],
LOA [auth 1a],
LOB [auth 2A],
LP [auth 1A],
LPA [auth 1a],
LPB [auth 2A],
LQ [auth 1A],
LQA [auth 1a],
LQB [auth 2A],
LR [auth 1A],
LRA [auth 1a],
LRB [auth 2B],
LS [auth 1A],
LSA [auth 1a],
LSB [auth 2S],
LT [auth 1A],
LTA [auth 2A],
LTB [auth 2a],
LU [auth 1A],
LUA [auth 2A],
LUB [auth 2a],
LV [auth 1A],
LVA [auth 2A],
LVB [auth 2a],
LW [auth 1A],
LWA [auth 2A],
LWB [auth 2a],
LX [auth 1A],
LXA [auth 2A],
LXB [auth 2a],
LY [auth 1A],
LYA [auth 2A],
LYB [auth 2a],
LZ [auth 1A],
LZA [auth 2A],
LZB [auth 2a],
MAA [auth 1A],
MAB [auth 2A],
MBA [auth 1A],
MBB [auth 2A],
MCA [auth 1A],
MCB [auth 2A],
MD [auth 1A],
MDA [auth 1A],
MDB [auth 2A],
ME [auth 1A],
MEA [auth 1A],
MEB [auth 2A],
MF [auth 1A],
MFA [auth 1A],
MFB [auth 2A],
MG [auth 1A],
MGA [auth 1A],
MGB [auth 2A],
MH [auth 1A],
MHA [auth 1B],
MHB [auth 2A],
MI [auth 1A],
MIA [auth 1D],
MIB [auth 2A],
MJ [auth 1A],
MJA [auth 1P],
MJB [auth 2A],
MK [auth 1A],
MKA [auth 14],
MKB [auth 2A],
ML [auth 1A],
MLA [auth 1a],
MLB [auth 2A],
MM [auth 1A],
MMA [auth 1a],
MMB [auth 2A],
MN [auth 1A],
MNA [auth 1a],
MNB [auth 2A],
MO [auth 1A],
MOA [auth 1a],
MOB [auth 2A],
MP [auth 1A],
MPA [auth 1a],
MPB [auth 2A],
MQ [auth 1A],
MQA [auth 1a],
MQB [auth 2A],
MR [auth 1A],
MRA [auth 1a],
MRB [auth 2B],
MS [auth 1A],
MSA [auth 1a],
MSB [auth 2S],
MT [auth 1A],
MTA [auth 2A],
MTB [auth 2a],
MU [auth 1A],
MUA [auth 2A],
MUB [auth 2a],
MV [auth 1A],
MVA [auth 2A],
MVB [auth 2a],
MW [auth 1A],
MWA [auth 2A],
MWB [auth 2a],
MX [auth 1A],
MXA [auth 2A],
MXB [auth 2a],
MY [auth 1A],
MYA [auth 2A],
MYB [auth 2a],
MZ [auth 1A],
MZA [auth 2A],
MZB [auth 2a],
NAA [auth 1A],
NAB [auth 2A],
NBA [auth 1A],
NBB [auth 2A],
NCA [auth 1A],
NCB [auth 2A],
ND [auth 1A],
NDA [auth 1A],
NDB [auth 2A],
NE [auth 1A],
NEA [auth 1A],
NEB [auth 2A],
NF [auth 1A],
NFA [auth 1A],
NFB [auth 2A],
NG [auth 1A],
NGA [auth 1A],
NGB [auth 2A],
NH [auth 1A],
NHA [auth 1B],
NHB [auth 2A],
NI [auth 1A],
NIA [auth 1D],
NIB [auth 2A],
NJ [auth 1A],
NJA [auth 1S],
NJB [auth 2A],
NK [auth 1A],
NKB [auth 2A],
NL [auth 1A],
NLA [auth 1a],
NLB [auth 2A],
NM [auth 1A],
NMA [auth 1a],
NMB [auth 2A],
NN [auth 1A],
NNA [auth 1a],
NNB [auth 2A],
NO [auth 1A],
NOA [auth 1a],
NOB [auth 2A],
NP [auth 1A],
NPA [auth 1a],
NPB [auth 2A],
NQ [auth 1A],
NQA [auth 1a],
NQB [auth 2A],
NR [auth 1A],
NRA [auth 1a],
NRB [auth 2B],
NS [auth 1A],
NSA [auth 1a],
NT [auth 1A],
NTA [auth 2A],
NTB [auth 2a],
NU [auth 1A],
NUA [auth 2A],
NUB [auth 2a],
NV [auth 1A],
NVA [auth 2A],
NVB [auth 2a],
NW [auth 1A],
NWA [auth 2A],
NWB [auth 2a],
NX [auth 1A],
NXA [auth 2A],
NXB [auth 2a],
NY [auth 1A],
NYA [auth 2A],
NYB [auth 2a],
NZ [auth 1A],
NZA [auth 2A],
NZB [auth 2a],
OAA [auth 1A],
OAB [auth 2A],
OBA [auth 1A],
OBB [auth 2A],
OCA [auth 1A],
OCB [auth 2A],
OD [auth 1A],
ODA [auth 1A],
ODB [auth 2A],
OE [auth 1A],
OEA [auth 1A],
OEB [auth 2A],
OF [auth 1A],
OFA [auth 1A],
OFB [auth 2A],
OG [auth 1A],
OGA [auth 1A],
OGB [auth 2A],
OH [auth 1A],
OHA [auth 1B],
OHB [auth 2A],
OI [auth 1A],
OIA [auth 1E],
OIB [auth 2A],
OJ [auth 1A],
OJA [auth 1S],
OJB [auth 2A],
OK [auth 1A],
OKA [auth 15],
OKB [auth 2A],
OL [auth 1A],
OLA [auth 1a],
OLB [auth 2A],
OM [auth 1A],
OMA [auth 1a],
OMB [auth 2A],
ON [auth 1A],
ONA [auth 1a],
ONB [auth 2A],
OO [auth 1A],
OOA [auth 1a],
OOB [auth 2A],
OP [auth 1A],
OPA [auth 1a],
OPB [auth 2A],
OQ [auth 1A],
OQA [auth 1a],
OQB [auth 2A],
OR [auth 1A],
ORA [auth 1a],
ORB [auth 2B],
OS [auth 1A],
OSA [auth 1a],
OSB [auth 2W],
OT [auth 1A],
OTA [auth 2A],
OTB [auth 2a],
OU [auth 1A],
OUA [auth 2A],
OUB [auth 2a],
OV [auth 1A],
OVA [auth 2A],
OVB [auth 2a],
OW [auth 1A],
OWA [auth 2A],
OWB [auth 2a],
OX [auth 1A],
OXA [auth 2A],
OXB [auth 2a],
OY [auth 1A],
OYA [auth 2A],
OYB [auth 2a],
OZ [auth 1A],
OZA [auth 2A],
PAA [auth 1A],
PAB [auth 2A],
PBA [auth 1A],
PBB [auth 2A],
PCA [auth 1A],
PCB [auth 2A],
PD [auth 1A],
PDA [auth 1A],
PDB [auth 2A],
PE [auth 1A],
PEA [auth 1A],
PEB [auth 2A],
PF [auth 1A],
PFA [auth 1A],
PFB [auth 2A],
PG [auth 1A],
PGA [auth 1A],
PGB [auth 2A],
PH [auth 1A],
PHA [auth 1B],
PHB [auth 2A],
PI [auth 1A],
PIA [auth 1E],
PIB [auth 2A],
PJ [auth 1A],
PJA [auth 1S],
PJB [auth 2A],
PK [auth 1A],
PKA [auth 15],
PKB [auth 2A],
PL [auth 1A],
PLA [auth 1a],
PLB [auth 2A],
PM [auth 1A],
PMA [auth 1a],
PMB [auth 2A],
PN [auth 1A],
PNA [auth 1a],
PNB [auth 2A],
PO [auth 1A],
POA [auth 1a],
POB [auth 2A],
PP [auth 1A],
PPA [auth 1a],
PPB [auth 2A],
PQ [auth 1A],
PQA [auth 1a],
PQB [auth 2A],
PR [auth 1A],
PRA [auth 1a],
PRB [auth 2B],
PS [auth 1A],
PSA [auth 1a],
PSB [auth 2Y],
PT [auth 1A],
PTA [auth 2A],
PTB [auth 2a],
PU [auth 1A],
PUA [auth 2A],
PUB [auth 2a],
PV [auth 1A],
PVA [auth 2A],
PVB [auth 2a],
PW [auth 1A],
PWA [auth 2A],
PWB [auth 2a],
PX [auth 1A],
PXA [auth 2A],
PXB [auth 2a],
PY [auth 1A],
PYA [auth 2A],
PYB [auth 2a],
PZ [auth 1A],
PZA [auth 2A],
PZB [auth 2d],
QAA [auth 1A],
QAB [auth 2A],
QBA [auth 1A],
QBB [auth 2A],
QCA [auth 1A],
QCB [auth 2A],
QD [auth 1A],
QDA [auth 1A],
QDB [auth 2A],
QE [auth 1A],
QEA [auth 1A],
QEB [auth 2A],
QF [auth 1A],
QFA [auth 1A],
QFB [auth 2A],
QG [auth 1A],
QGA [auth 1A],
QGB [auth 2A],
QH [auth 1A],
QHA [auth 1B],
QHB [auth 2A],
QI [auth 1A],
QIA [auth 1E],
QIB [auth 2A],
QJ [auth 1A],
QJA [auth 1S],
QJB [auth 2A],
QK [auth 1A],
QKA [auth 16],
QKB [auth 2A],
QL [auth 1A],
QLA [auth 1a],
QLB [auth 2A],
QM [auth 1A],
QMA [auth 1a],
QMB [auth 2A],
QN [auth 1A],
QNA [auth 1a],
QNB [auth 2A],
QO [auth 1A],
QOA [auth 1a],
QOB [auth 2A],
QP [auth 1A],
QPA [auth 1a],
QPB [auth 2A],
QQ [auth 1A],
QQA [auth 1a],
QQB [auth 2A],
QR [auth 1A],
QRA [auth 1a],
QRB [auth 2B],
QS [auth 1A],
QSA [auth 1a],
QT [auth 1A],
QTA [auth 2A],
QTB [auth 2a],
QU [auth 1A],
QUA [auth 2A],
QUB [auth 2a],
QV [auth 1A],
QVA [auth 2A],
QVB [auth 2a],
QW [auth 1A],
QWA [auth 2A],
QWB [auth 2a],
QX [auth 1A],
QXA [auth 2A],
QXB [auth 2a],
QY [auth 1A],
QYA [auth 2A],
QYB [auth 2a],
QZ [auth 1A],
QZA [auth 2A],
QZB [auth 2f],
RAA [auth 1A],
RAB [auth 2A],
RBA [auth 1A],
RBB [auth 2A],
RCA [auth 1A],
RCB [auth 2A],
RD [auth 1A],
RDA [auth 1A],
RDB [auth 2A],
RE [auth 1A],
REA [auth 1A],
REB [auth 2A],
RF [auth 1A],
RFA [auth 1A],
RFB [auth 2A],
RG [auth 1A],
RGA [auth 1A],
RGB [auth 2A],
RH [auth 1A],
RHA [auth 1B],
RHB [auth 2A],
RI [auth 1A],
RIA [auth 1E],
RIB [auth 2A],
RJ [auth 1A],
RJA [auth 1T],
RJB [auth 2A],
RK [auth 1A],
RKA [auth 16],
RKB [auth 2A],
RL [auth 1A],
RLA [auth 1a],
RLB [auth 2A],
RM [auth 1A],
RMA [auth 1a],
RMB [auth 2A],
RN [auth 1A],
RNA [auth 1a],
RNB [auth 2A],
RO [auth 1A],
ROA [auth 1a],
ROB [auth 2A],
RP [auth 1A],
RPA [auth 1a],
RPB [auth 2A],
RQ [auth 1A],
RQA [auth 1a],
RQB [auth 2A],
RR [auth 1A],
RRA [auth 1a],
RRB [auth 2B],
RS [auth 1A],
RSA [auth 1b],
RT [auth 1A],
RTA [auth 2A],
RTB [auth 2a],
RU [auth 1A],
RUA [auth 2A],
RUB [auth 2a],
RV [auth 1A],
RVA [auth 2A],
RVB [auth 2a],
RW [auth 1A],
RWA [auth 2A],
RWB [auth 2a],
RX [auth 1A],
RXA [auth 2A],
RXB [auth 2a],
RY [auth 1A],
RYA [auth 2A],
RYB [auth 2a],
RZ [auth 1A],
RZA [auth 2A],
RZB [auth 2f],
SAA [auth 1A],
SAB [auth 2A],
SBA [auth 1A],
SBB [auth 2A],
SCA [auth 1A],
SCB [auth 2A],
SD [auth 1A],
SDA [auth 1A],
SDB [auth 2A],
SE [auth 1A],
SEA [auth 1A],
SEB [auth 2A],
SF [auth 1A],
SFA [auth 1A],
SFB [auth 2A],
SG [auth 1A],
SGA [auth 1A],
SGB [auth 2A],
SH [auth 1A],
SHA [auth 1B],
SHB [auth 2A],
SI [auth 1A],
SIA [auth 1E],
SIB [auth 2A],
SJ [auth 1A],
SJA [auth 1U],
SJB [auth 2A],
SK [auth 1A],
SKA [auth 17],
SKB [auth 2A],
SL [auth 1A],
SLA [auth 1a],
SLB [auth 2A],
SM [auth 1A],
SMA [auth 1a],
SMB [auth 2A],
SN [auth 1A],
SNA [auth 1a],
SNB [auth 2A],
SO [auth 1A],
SOA [auth 1a],
SOB [auth 2A],
SP [auth 1A],
SPA [auth 1a],
SPB [auth 2A],
SQ [auth 1A],
SQA [auth 1a],
SQB [auth 2A],
SR [auth 1A],
SRA [auth 1a],
SRB [auth 2D],
SS [auth 1A],
SSB [auth 23],
ST [auth 1A],
STA [auth 2A],
STB [auth 2a],
SU [auth 1A],
SUA [auth 2A],
SUB [auth 2a],
SV [auth 1A],
SVA [auth 2A],
SVB [auth 2a],
SW [auth 1A],
SWA [auth 2A],
SWB [auth 2a],
SX [auth 1A],
SXA [auth 2A],
SXB [auth 2a],
SY [auth 1A],
SYA [auth 2A],
SYB [auth 2a],
SZ [auth 1A],
SZA [auth 2A],
SZB [auth 2j],
TAA [auth 1A],
TAB [auth 2A],
TBA [auth 1A],
TBB [auth 2A],
TCA [auth 1A],
TCB [auth 2A],
TD [auth 1A],
TDA [auth 1A],
TDB [auth 2A],
TE [auth 1A],
TEA [auth 1A],
TEB [auth 2A],
TF [auth 1A],
TFA [auth 1A],
TFB [auth 2A],
TG [auth 1A],
TGA [auth 1A],
TGB [auth 2A],
TH [auth 1A],
THA [auth 1B],
THB [auth 2A],
TI [auth 1A],
TIA [auth 1E],
TIB [auth 2A],
TJ [auth 1A],
TJA [auth 1U],
TJB [auth 2A],
TK [auth 1A],
TKB [auth 2A],
TL [auth 1A],
TLA [auth 1a],
TLB [auth 2A],
TM [auth 1A],
TMA [auth 1a],
TMB [auth 2A],
TN [auth 1A],
TNA [auth 1a],
TNB [auth 2A],
TO [auth 1A],
TOA [auth 1a],
TOB [auth 2A],
TP [auth 1A],
TPA [auth 1a],
TPB [auth 2A],
TQ [auth 1A],
TQA [auth 1a],
TQB [auth 2A],
TR [auth 1A],
TRA [auth 1a],
TRB [auth 2D],
TS [auth 1A],
TSA [auth 1d],
TT [auth 1A],
TTA [auth 2A],
TTB [auth 2a],
TU [auth 1A],
TUA [auth 2A],
TUB [auth 2a],
TV [auth 1A],
TVA [auth 2A],
TVB [auth 2a],
TW [auth 1A],
TWA [auth 2A],
TWB [auth 2a],
TX [auth 1A],
TXA [auth 2A],
TXB [auth 2a],
TY [auth 1A],
TYA [auth 2A],
TYB [auth 2a],
TZ [auth 1A],
TZA [auth 2A],
TZB [auth 2l],
UAA [auth 1A],
UAB [auth 2A],
UBA [auth 1A],
UBB [auth 2A],
UCA [auth 1A],
UCB [auth 2A],
UD [auth 1A],
UDA [auth 1A],
UDB [auth 2A],
UE [auth 1A],
UEA [auth 1A],
UEB [auth 2A],
UF [auth 1A],
UFA [auth 1A],
UFB [auth 2A],
UG [auth 1A],
UGA [auth 1A],
UGB [auth 2A],
UH [auth 1A],
UHA [auth 1B],
UHB [auth 2A],
UI [auth 1A],
UIA [auth 1F],
UIB [auth 2A],
UJ [auth 1A],
UJA [auth 1U],
UJB [auth 2A],
UK [auth 1A],
UKA [auth 17],
UKB [auth 2A],
UL [auth 1A],
ULA [auth 1a],
ULB [auth 2A],
UM [auth 1A],
UMA [auth 1a],
UMB [auth 2A],
UN [auth 1A],
UNA [auth 1a],
UNB [auth 2A],
UO [auth 1A],
UOA [auth 1a],
UOB [auth 2A],
UP [auth 1A],
UPA [auth 1a],
UPB [auth 2A],
UQ [auth 1A],
UQA [auth 1a],
UQB [auth 2A],
UR [auth 1A],
URA [auth 1a],
URB [auth 2D],
US [auth 1A],
USA [auth 1d],
USB [auth 26],
UT [auth 1A],
UTA [auth 2A],
UTB [auth 2a],
UU [auth 1A],
UUA [auth 2A],
UUB [auth 2a],
UV [auth 1A],
UVA [auth 2A],
UVB [auth 2a],
UW [auth 1A],
UWA [auth 2A],
UWB [auth 2a],
UX [auth 1A],
UXA [auth 2A],
UXB [auth 2a],
UY [auth 1A],
UYA [auth 2A],
UYB [auth 2a],
UZ [auth 1A],
UZA [auth 2A],
VAA [auth 1A],
VAB [auth 2A],
VBA [auth 1A],
VBB [auth 2A],
VCA [auth 1A],
VCB [auth 2A],
VD [auth 1A],
VDA [auth 1A],
VDB [auth 2A],
VE [auth 1A],
VEA [auth 1A],
VEB [auth 2A],
VF [auth 1A],
VFA [auth 1A],
VFB [auth 2A],
VG [auth 1A],
VGA [auth 1A],
VGB [auth 2A],
VH [auth 1A],
VHA [auth 1B],
VHB [auth 2A],
VI [auth 1A],
VIA [auth 1F],
VIB [auth 2A],
VJ [auth 1A],
VJA [auth 1W],
VJB [auth 2A],
VK [auth 1A],
VKA [auth 1a],
VKB [auth 2A],
VL [auth 1A],
VLA [auth 1a],
VLB [auth 2A],
VM [auth 1A],
VMA [auth 1a],
VMB [auth 2A],
VN [auth 1A],
VNA [auth 1a],
VNB [auth 2A],
VO [auth 1A],
VOA [auth 1a],
VOB [auth 2A],
VP [auth 1A],
VPA [auth 1a],
VPB [auth 2A],
VQ [auth 1A],
VQA [auth 1a],
VQB [auth 2A],
VR [auth 1A],
VRA [auth 1a],
VRB [auth 2D],
VS [auth 1A],
VSA [auth 1f],
VSB [auth 26],
VT [auth 1A],
VTA [auth 2A],
VTB [auth 2a],
VU [auth 1A],
VUA [auth 2A],
VUB [auth 2a],
VV [auth 1A],
VVA [auth 2A],
VVB [auth 2a],
VW [auth 1A],
VWA [auth 2A],
VWB [auth 2a],
VX [auth 1A],
VXA [auth 2A],
VXB [auth 2a],
VY [auth 1A],
VYA [auth 2A],
VYB [auth 2a],
VZ [auth 1A],
VZA [auth 2A],
VZB [auth 2n],
WAA [auth 1A],
WAB [auth 2A],
WBA [auth 1A],
WBB [auth 2A],
WCA [auth 1A],
WCB [auth 2A],
WD [auth 1A],
WDA [auth 1A],
WDB [auth 2A],
WE [auth 1A],
WEA [auth 1A],
WEB [auth 2A],
WF [auth 1A],
WFA [auth 1A],
WFB [auth 2A],
WG [auth 1A],
WGA [auth 1A],
WGB [auth 2A],
WH [auth 1A],
WHA [auth 1B],
WHB [auth 2A],
WI [auth 1A],
WIA [auth 1F],
WIB [auth 2A],
WJ [auth 1A],
WJB [auth 2A],
WK [auth 1A],
WKA [auth 1a],
WKB [auth 2A],
WL [auth 1A],
WLA [auth 1a],
WLB [auth 2A],
WM [auth 1A],
WMA [auth 1a],
WMB [auth 2A],
WN [auth 1A],
WNA [auth 1a],
WNB [auth 2A],
WO [auth 1A],
WOA [auth 1a],
WOB [auth 2A],
WP [auth 1A],
WPA [auth 1a],
WPB [auth 2A],
WQ [auth 1A],
WQA [auth 1a],
WQB [auth 2A],
WR [auth 1A],
WRA [auth 1a],
WRB [auth 2E],
WS [auth 1A],
WSA [auth 1l],
WT [auth 1A],
WTA [auth 2A],
WTB [auth 2a],
WU [auth 1A],
WUA [auth 2A],
WUB [auth 2a],
WV [auth 1A],
WVA [auth 2A],
WVB [auth 2a],
WW [auth 1A],
WWA [auth 2A],
WWB [auth 2a],
WX [auth 1A],
WXA [auth 2A],
WXB [auth 2a],
WY [auth 1A],
WYA [auth 2A],
WYB [auth 2a],
WZ [auth 1A],
WZA [auth 2A],
WZB [auth 2q],
XAA [auth 1A],
XAB [auth 2A],
XBA [auth 1A],
XBB [auth 2A],
XCA [auth 1A],
XCB [auth 2A],
XD [auth 1A],
XDA [auth 1A],
XDB [auth 2A],
XE [auth 1A],
XEA [auth 1A],
XEB [auth 2A],
XF [auth 1A],
XFA [auth 1A],
XFB [auth 2A],
XG [auth 1A],
XGA [auth 1A],
XGB [auth 2A],
XH [auth 1A],
XHA [auth 1B],
XHB [auth 2A],
XI [auth 1A],
XIA [auth 1F],
XIB [auth 2A],
XJ [auth 1A],
XJA [auth 1X],
XJB [auth 2A],
XK [auth 1A],
XKA [auth 1a],
XKB [auth 2A],
XL [auth 1A],
XLA [auth 1a],
XLB [auth 2A],
XM [auth 1A],
XMA [auth 1a],
XMB [auth 2A],
XN [auth 1A],
XNA [auth 1a],
XNB [auth 2A],
XO [auth 1A],
XOA [auth 1a],
XOB [auth 2A],
XP [auth 1A],
XPA [auth 1a],
XPB [auth 2A],
XQ [auth 1A],
XQA [auth 1a],
XQB [auth 2A],
XR [auth 1A],
XRA [auth 1a],
XRB [auth 2E],
XS [auth 1A],
XSA [auth 1l],
XSB [auth 2a],
XT [auth 1A],
XTA [auth 2A],
XTB [auth 2a],
XU [auth 1A],
XUA [auth 2A],
XUB [auth 2a],
XV [auth 1A],
XVA [auth 2A],
XVB [auth 2a],
XW [auth 1A],
XWA [auth 2A],
XWB [auth 2a],
XX [auth 1A],
XXA [auth 2A],
XXB [auth 2a],
XY [auth 1A],
XYA [auth 2A],
XYB [auth 2a],
XZ [auth 1A],
XZA [auth 2A],
XZB [auth 2t],
YAA [auth 1A],
YAB [auth 2A],
YBA [auth 1A],
YBB [auth 2A],
YCA [auth 1A],
YCB [auth 2A],
YD [auth 1A],
YDA [auth 1A],
YDB [auth 2A],
YE [auth 1A],
YEA [auth 1A],
YEB [auth 2A],
YF [auth 1A],
YFA [auth 1A],
YFB [auth 2A],
YG [auth 1A],
YGA [auth 1A],
YGB [auth 2A],
YH [auth 1A],
YHA [auth 1B],
YHB [auth 2A],
YI [auth 1A],
YIA [auth 1F],
YIB [auth 2A],
YJ [auth 1A],
YJA [auth 1X],
YJB [auth 2A],
YK [auth 1A],
YKA [auth 1a],
YKB [auth 2A],
YL [auth 1A],
YLA [auth 1a],
YLB [auth 2A],
YM [auth 1A],
YMA [auth 1a],
YMB [auth 2A],
YN [auth 1A],
YNA [auth 1a],
YNB [auth 2A],
YO [auth 1A],
YOA [auth 1a],
YOB [auth 2A],
YP [auth 1A],
YPA [auth 1a],
YPB [auth 2A],
YQ [auth 1A],
YQA [auth 1a],
YQB [auth 2A],
YR [auth 1A],
YRA [auth 1a],
YRB [auth 2E],
YS [auth 1A],
YSA [auth 1l],
YSB [auth 2a],
YT [auth 1A],
YTA [auth 2A],
YTB [auth 2a],
YU [auth 1A],
YUA [auth 2A],
YUB [auth 2a],
YV [auth 1A],
YVA [auth 2A],
YVB [auth 2a],
YW [auth 1A],
YWA [auth 2A],
YWB [auth 2a],
YX [auth 1A],
YXA [auth 2A],
YXB [auth 2a],
YY [auth 1A],
YYA [auth 2A],
YYB [auth 2a],
YZ [auth 1A],
YZA [auth 2A],
YZB [auth 2z],
ZAA [auth 1A],
ZAB [auth 2A],
ZBA [auth 1A],
ZBB [auth 2A],
ZCA [auth 1A],
ZCB [auth 2A],
ZD [auth 1A],
ZDA [auth 1A],
ZDB [auth 2A],
ZE [auth 1A],
ZEA [auth 1A],
ZEB [auth 2A],
ZF [auth 1A],
ZFA [auth 1A],
ZFB [auth 2A],
ZG [auth 1A],
ZGA [auth 1A],
ZGB [auth 2A],
ZH [auth 1A],
ZHA [auth 1B],
ZHB [auth 2A],
ZI [auth 1A],
ZIA [auth 1F],
ZIB [auth 2A],
ZJ [auth 1A],
ZJA [auth 1Y],
ZJB [auth 2A],
ZK [auth 1A],
ZKA [auth 1a],
ZKB [auth 2A],
ZL [auth 1A],
ZLA [auth 1a],
ZLB [auth 2A],
ZM [auth 1A],
ZMA [auth 1a],
ZMB [auth 2A],
ZN [auth 1A],
ZNA [auth 1a],
ZNB [auth 2A],
ZO [auth 1A],
ZOA [auth 1a],
ZOB [auth 2A],
ZP [auth 1A],
ZPA [auth 1a],
ZPB [auth 2A],
ZQ [auth 1A],
ZQA [auth 1a],
ZQB [auth 2A],
ZR [auth 1A],
ZRA [auth 1a],
ZRB [auth 2E],
ZS [auth 1A],
ZSB [auth 2a],
ZT [auth 1A],
ZTA [auth 2A],
ZTB [auth 2a],
ZU [auth 1A],
ZUA [auth 2A],
ZUB [auth 2a],
ZV [auth 1A],
ZVA [auth 2A],
ZVB [auth 2a],
ZW [auth 1A],
ZWA [auth 2A],
ZWB [auth 2a],
ZX [auth 1A],
ZXA [auth 2A],
ZXB [auth 2a],
ZY [auth 1A],
ZYA [auth 2A],
ZYB [auth 2a],
ZZ [auth 1A],
ZZA [auth 2A]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.00 Å
  • R-Value Free: 0.265 
  • R-Value Work: 0.208 
  • R-Value Observed: 0.211 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 208.782α = 90
b = 449.03β = 90
c = 619.335γ = 90
Software Package:
Software NamePurpose
PHENIXrefinement
XDSdata reduction
XSCALEdata scaling
PHASERphasing
Cootmodel building
PDB_EXTRACTdata extraction

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


View more in-depth experimental data
Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesGM022778
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesGM106386
Howard Hughes Medical Institute (HHMI)United States--

Revision History  (Full details and data files)

  • Version 1.0: 2016-04-06
    Type: Initial release
  • Version 1.1: 2017-09-20
    Changes: Advisory, Author supporting evidence, Database references, Derived calculations
  • Version 1.2: 2019-11-20
    Changes: Author supporting evidence
  • Version 1.3: 2020-02-05
    Changes: Derived calculations
  • Version 1.4: 2024-03-06
    Changes: Advisory, Data collection, Database references, Derived calculations