Crystal structure of mouse CARM1 in complex with inhibitor SA0707
Cura, V., Marechal, N., Mailliot, J., Troffer-Charlier, N., Wurtz, J.M., Bonnefond, L., Cavarelli, J.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Histone-arginine methyltransferase CARM1 | 361 | Mus musculus | Mutation(s): 0  Gene Names: Carm1, Prmt4 EC: 2.1.1.319 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9WVG6 (Mus musculus) Explore Q9WVG6  Go to UniProtKB:  Q9WVG6 | |||||
IMPC:  MGI:1913208 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q9WVG6 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 6 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
6D6 Query on 6D6 | AA [auth C], GA [auth D], M [auth A], T [auth B] | 5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl)amino}-5'-deoxyadenosine C17 H28 N8 O5 NHAKJKNYYCYZBR-UOYPZJKHSA-N | |||
PG6 Query on PG6 | K [auth A] | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE C12 H26 O6 DMDPGPKXQDIQQG-UHFFFAOYSA-N | |||
M2M Query on M2M | N [auth A] | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE C6 H14 O3 SBZXBUIDTXKZTM-UHFFFAOYSA-N | |||
PEG Query on PEG | FA [auth D], L [auth A] | DI(HYDROXYETHYL)ETHER C4 H10 O3 MTHSVFCYNBDYFN-UHFFFAOYSA-N | |||
DXE Query on DXE | E [auth A], F [auth A], O [auth B] | 1,2-DIMETHOXYETHANE C4 H10 O2 XTHFKEDIFFGKHM-UHFFFAOYSA-N | |||
EDO Query on EDO | BA [auth D] CA [auth D] DA [auth D] EA [auth D] G [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 74.689 | α = 90 |
b = 98.16 | β = 90 |
c = 205.108 | γ = 90 |
Software Name | Purpose |
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PHENIX | refinement |
HKL-2000 | data reduction |
SCALEPACK | data scaling |
PHASER | phasing |