Download MendeleyTowards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines.
Schroder, S.P., van de Sande, J.W., Kallemeijn, W.W., Kuo, C.L., Artola, M., van Rooden, E.J., Jiang, J., Beenakker, T.J.M., Florea, B.I., Offen, W.A., Davies, G.J., Minnaard, A.J., Aerts, J.M.F.G., Codee, J.D.C., van der Marel, G.A., Overkleeft, H.S.(2017) Chem Commun (Camb) 53: 12528-12531
- PubMed: 29116266
- DOI: https://doi.org/10.1039/c7cc07730k
- Primary Citation of Related Structures:
5JAW - PubMed Abstract:
Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of β-glucosidases and β-galactosidases.
Organizational Affiliation:
Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands. [email protected].
