Download MendeleyHuman STK10 bound to dovitinib
Elkins, J.M.To be published.
5OWQ
Human STK10 bound to dovitinib
- PDB DOI: https://doi.org/10.2210/pdb5OWQ/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2017-09-04 Released: 2017-09-13
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.70 Å
- R-Value Free: 0.305
- R-Value Work: 0.263
- R-Value Observed: 0.265
Starting Model: other
View more details
This is version 1.3 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Serine/threonine-protein kinase 10 | 302 | Homo sapiens | Mutation(s): 0 Gene Names: STK10, LOK EC: 2.7.11.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O94804 (Homo sapiens) Explore O94804 Go to UniProtKB: O94804 | |||||
PHAROS: O94804 GTEx: ENSG00000072786 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | O94804 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 38O Query on 38O | C [auth A], D [auth B] | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one C21 H21 F N6 O PIQCTGMSNWUMAF-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.70 Å
- R-Value Free: 0.305
- R-Value Work: 0.263
- R-Value Observed: 0.265
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 57.57 | α = 90 |
| b = 50.4 | β = 96.6 |
| c = 114.57 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| Aimless | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2017-09-13 Deposition Author(s): Szklarz, M., von Delft, F., Bountra, C., Knapp, S., Edwards, A.M., Arrowsmith, C., Elkins, J.M.
Revision History (Full details and data files)
- Version 1.0: 2017-09-13
Type: Initial release - Version 1.1: 2018-01-24
Changes: Source and taxonomy - Version 1.2: 2024-05-01
Changes: Data collection, Database references, Refinement description - Version 1.3: 2024-10-23
Changes: Structure summary
