Download MendeleyA comparison of the steroid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis
Child, S.A., Bruning, J.B., Bell, S.G.To be published.
6CVC
Mycobacterium marinum cytochrome P450 CYP124A1 in the substrate-free form
- PDB DOI: https://doi.org/10.2210/pdb6CVC/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Mycobacterium marinum M
- Expression System: Escherichia coli BL21
- Mutation(s): No
- Deposited: 2018-03-27 Released: 2019-03-27
- Funding Organization(s): Australian Research Council (ARC)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.20 Å
- R-Value Free: 0.254
- R-Value Work: 0.204
- R-Value Observed: 0.207
Starting Model: experimental
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This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Cytochrome P450 124A1, Cyp124A1 | 433 | Mycobacterium marinum M | Mutation(s): 0 Gene Names: cyp124A1, MMAR_3361 |  | |
UniProt | |||||
Find proteins for B2HHT9 (Mycobacterium marinum (strain ATCC BAA-535 / M)) Explore B2HHT9 Go to UniProtKB: B2HHT9 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | B2HHT9 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| HEM Query on HEM | B [auth A] | PROTOPORPHYRIN IX CONTAINING FE C34 H32 Fe N4 O4 KABFMIBPWCXCRK-RGGAHWMASA-L |  | ||
| SO4 Query on SO4 | C [auth A], D [auth A], E [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.20 Å
- R-Value Free: 0.254
- R-Value Work: 0.204
- R-Value Observed: 0.207
- Space Group: C 1 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 98.776 | α = 90 |
| b = 72.359 | β = 109.72 |
| c = 65.602 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
| PDB_EXTRACT | data extraction |
Entry History & Funding Information
Deposition Data
- Released Date: 2019-03-27 Deposition Author(s): Child, S.A., Bruning, J.B., Bell, S.G.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Australian Research Council (ARC) | Australia | FT140100355 |
Revision History (Full details and data files)
- Version 1.0: 2019-03-27
Type: Initial release - Version 1.1: 2020-01-01
Changes: Author supporting evidence - Version 1.2: 2023-10-04
Changes: Data collection, Database references, Refinement description
