Download MendeleyCrystal structure of PPAR gamma in complex with NMP422
Mou, T.C., Chrisman, I.M., Hughes, T.S., Sprang, S.R.To be published.
6DCU
Crystal structure of PPAR gamma co-crystallized with nTZDpa
- PDB DOI: https://doi.org/10.2210/pdb6DCU/pdb
- Classification: dna binding protein/agonist
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2018-05-08 Released: 2019-05-15
- Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.95 Å
- R-Value Free: 0.303
- R-Value Work: 0.264
- R-Value Observed: 0.550
Starting Model: experimental
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This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Peroxisome proliferator-activated receptor gamma | 301 | Homo sapiens | Mutation(s): 0 Gene Names: PPARG, NR1C3 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P37231 (Homo sapiens) Explore P37231 Go to UniProtKB: P37231 | |||||
PHAROS: P37231 GTEx: ENSG00000132170 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P37231 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NZA Query on NZA | C [auth A], D [auth B] | 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID C22 H15 Cl2 N O2 S VUPOTURDKDMIGQ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.95 Å
- R-Value Free: 0.303
- R-Value Work: 0.264
- R-Value Observed: 0.550
- Space Group: H 3
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 94.085 | α = 90 |
| b = 94.085 | β = 90 |
| c = 192.424 | γ = 120 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2019-05-15 Deposition Author(s): Mou, T.C., Chrisman, I.M., Hughes, T.S., Sprang, S.R.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | P20GM103546 |
| National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) | United States | R00DK103116 |
Revision History (Full details and data files)
- Version 1.0: 2019-05-15
Type: Initial release - Version 1.1: 2019-12-25
Changes: Author supporting evidence - Version 1.2: 2023-10-11
Changes: Data collection, Database references, Refinement description
