Download MendeleyStructural Variants of Transthyretin
Saelices, L., Chung, K., Esswein, S., Chou, J., Liang, W., Li, J.H., Sawaya, M.R., Cascio, D., Eisenberg, D.To be published.
6E76
Structure of Human Transthyretin Asp38Ala/Thr119Met Mutant
- PDB DOI: https://doi.org/10.2210/pdb6E76/pdb
- Classification: TRANSPORT PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2018-07-25 Released: 2019-07-31
- Funding Organization(s): National Institutes of Health/National Institute on Aging (NIH/NIA)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.60 Å
- R-Value Free: 0.216
- R-Value Work: 0.191
- R-Value Observed: 0.194
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Transthyretin | 115 | Homo sapiens | Mutation(s): 2 Gene Names: TTR, PALB |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P02766 (Homo sapiens) Explore P02766 Go to UniProtKB: P02766 | |||||
PHAROS: P02766 GTEx: ENSG00000118271 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P02766 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SO4 Query on SO4 | E [auth B] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| GOL Query on GOL | C [auth A], D [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| ACT Query on ACT | F [auth B], G [auth B] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M |  | ||
| Modified Residues 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Type | Formula | 2D Diagram | Parent |
| OCS Query on OCS | A, B | L-PEPTIDE LINKING | C3 H7 N O5 S |  | CYS |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.60 Å
- R-Value Free: 0.216
- R-Value Work: 0.191
- R-Value Observed: 0.194
- Space Group: P 21 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 43.33 | α = 90 |
| b = 85.33 | β = 90 |
| c = 63.51 | γ = 90 |
| Software Name | Purpose |
|---|---|
| XSCALE | data scaling |
| PHENIX | refinement |
| PDB_EXTRACT | data extraction |
| XDS | data reduction |
Entry History & Funding Information
Deposition Data
- Released Date: 2019-07-31 Deposition Author(s): Saelices, L., Chung, K., Sawaya, M.R., Cascio, D., Eisenberg, D.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute on Aging (NIH/NIA) | United States | AG048120 |
Revision History (Full details and data files)
- Version 1.0: 2019-07-31
Type: Initial release - Version 1.1: 2019-12-18
Changes: Author supporting evidence
