Download MendeleyStructure of human hydroxyacid oxidase 1 bound with FMN and glycolate
MacKinnon, S., Bezerra, G.A., Krojer, T., Smee, C., Arrowsmith, C.H., Edwards, E., Bountra, C., Oppermann, U., Brennan, P.E., Yue, W.W.To be published.
6GMB
Structure of human hydroxyacid oxidase 1 bound with FMN and glycolate
- PDB DOI: https://doi.org/10.2210/pdb6GMB/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2018-05-24 Released: 2018-06-13
- Funding Organization(s): Wellcome Trust
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.35 Å
- R-Value Free: 0.130
- R-Value Work: 0.110
- R-Value Observed: 0.111
Starting Model: experimental
View more details
This is version 2.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hydroxyacid oxidase 1 | 362 | Homo sapiens | Mutation(s): 0 Gene Names: HAO1, GOX1, HAOX1 EC: 1.1.3.15 (PDB Primary Data), 1.2.3.5 (UniProt) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9UJM8 (Homo sapiens) Explore Q9UJM8 Go to UniProtKB: Q9UJM8 | |||||
PHAROS: Q9UJM8 GTEx: ENSG00000101323 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9UJM8 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| FMN Query on FMN | G [auth A] | FLAVIN MONONUCLEOTIDE C17 H21 N4 O9 P FVTCRASFADXXNN-SCRDCRAPSA-N |  | ||
| PG4 Query on PG4 | D [auth A] | TETRAETHYLENE GLYCOL C8 H18 O5 UWHCKJMYHZGTIT-UHFFFAOYSA-N |  | ||
| GOA Query on GOA | H [auth A] | GLYCOLIC ACID C2 H4 O3 AEMRFAOFKBGASW-UHFFFAOYSA-N |  | ||
| EDO Query on EDO | B [auth A], C [auth A], E [auth A], F [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.35 Å
- R-Value Free: 0.130
- R-Value Work: 0.110
- R-Value Observed: 0.111
- Space Group: I 4
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 97.431 | α = 90 |
| b = 97.431 | β = 90 |
| c = 80.364 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| SCALA | data scaling |
| PDB_EXTRACT | data extraction |
| SCALA | data scaling |
| PHASER | phasing |
| XDS | data reduction |
Entry History & Funding Information
Deposition Data
- Released Date: 2018-06-13 Deposition Author(s): MacKinnon, S., Bezerra, G.A., Krojer, T., Smee, C., Arrowsmith, C.H., Edwards, E., Bountra, C., Oppermann, U., Brennan, P.E., Yue, W.W., Structural Genomics Consortium (SGC)
| Funding Organization | Location | Grant Number |
|---|---|---|
| Wellcome Trust | United Kingdom | 106169/ZZ14/Z |
Revision History (Full details and data files)
- Version 1.0: 2018-06-13
Type: Initial release - Version 2.0: 2023-11-15
Changes: Atomic model, Data collection, Database references - Version 2.1: 2024-01-17
Changes: Refinement description
