Download MendeleyMichaelis-like complex of mouse ketohexokinase isoform C
Gasper, W.C., Gardner, S., Ross, A., Oppelt, S.A., Allen, K.N., Tolan, D.R.(2024) Acta Crystallogr D Biol Crystallogr
6P2D
Structure of mouse ketohexokinase-C in complex with fructose and ADP
- PDB DOI: https://doi.org/10.2210/pdb6P2D/pdb
- Classification: TRANSFERASE
- Organism(s): Mus musculus
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2019-05-21 Released: 2020-06-03
- Funding Organization(s): Not funded
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.79 Å
- R-Value Free: 0.220
- R-Value Work: 0.170
Starting Model: experimental
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This is version 2.1 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ketohexokinase | 315 | Mus musculus | Mutation(s): 0 Gene Names: Khk, mCG_23498 EC: 2.7.1.3 |  | |
UniProt | |||||
Find proteins for P97328 (Mus musculus) Explore P97328 Go to UniProtKB: P97328 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P97328 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ADP (Subject of Investigation/LOI) Query on ADP | B [auth A] | ADENOSINE-5'-DIPHOSPHATE C10 H15 N5 O10 P2 XTWYTFMLZFPYCI-KQYNXXCUSA-N |  | ||
| FRU (Subject of Investigation/LOI) Query on FRU | C [auth A] | beta-D-fructofuranose C6 H12 O6 RFSUNEUAIZKAJO-ARQDHWQXSA-N |  | ||
| NO3 Query on NO3 | D [auth A] | NITRATE ION N O3 NHNBFGGVMKEFGY-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.79 Å
- R-Value Free: 0.220
- R-Value Work: 0.170
- Space Group: C 2 2 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 42.252 | α = 90 |
| b = 78.446 | β = 90 |
| c = 150.772 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| PHENIX | refinement |
| SADABS | data scaling |
| PDB_EXTRACT | data extraction |
| SAINT | data reduction |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2020-06-03 Deposition Author(s): Gasper, W.C., Allen, K.N., Tolan, D.R.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Not funded | -- |
Revision History (Full details and data files)
- Version 1.0: 2020-06-03
Type: Initial release - Version 1.1: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Data collection, Derived calculations, Structure summary - Version 1.2: 2023-10-11
Changes: Data collection, Database references, Refinement description, Structure summary - Version 2.0: 2024-05-29
Type: Coordinate replacement
Reason: Model orientation/position
Changes: Advisory, Atomic model, Author supporting evidence, Data collection, Database references, Derived calculations, Non-polymer description, Refinement description, Source and taxonomy, Structure summary - Version 2.1: 2024-10-09
Changes: Structure summary
