Download MendeleyStructure of a phosphomimetic switch 2 variant of Rab8a in complex with the phospho-Rab binding domain of RILPL2
Khan, A.R., Waschbusch, D.To be published.
6SQ2
Structure of a phosphomimetic switch 2 variant of Rab8a in complex with the phospho-Rab binding domain of RILPL2
- PDB DOI: https://doi.org/10.2210/pdb6SQ2/pdb
- Classification: SIGNALING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2019-09-03 Released: 2020-09-30
- Funding Organization(s): Science Foundation Ireland
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.68 Å
- R-Value Free: 0.202
- R-Value Work: 0.181
- R-Value Observed: 0.182
Starting Model: experimental
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This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ras-related protein Rab-8A | 184 | Homo sapiens | Mutation(s): 2 Gene Names: RAB8A, MEL, RAB8 EC: 3.6.5.2 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61006 (Homo sapiens) Explore P61006 Go to UniProtKB: P61006 | |||||
PHAROS: P61006 GTEx: ENSG00000167461 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P61006 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| RILP-like protein 2 | C [auth D], D [auth E] | 43 | Homo sapiens | Mutation(s): 0 Gene Names: RILPL2, RLP2 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q969X0 (Homo sapiens) Explore Q969X0 Go to UniProtKB: Q969X0 | |||||
PHAROS: Q969X0 GTEx: ENSG00000150977 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q969X0 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GTP Query on GTP | E [auth A], G [auth B] | GUANOSINE-5'-TRIPHOSPHATE C10 H16 N5 O14 P3 XKMLYUALXHKNFT-UUOKFMHZSA-N |  | ||
| MG Query on MG | F [auth A], H [auth B] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.68 Å
- R-Value Free: 0.202
- R-Value Work: 0.181
- R-Value Observed: 0.182
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 60.698 | α = 90 |
| b = 71.733 | β = 90 |
| c = 116.39 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| PDB_EXTRACT | data extraction |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2020-09-30 Deposition Author(s): Khan, A.R., Waschbusch, D.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Science Foundation Ireland | Ireland | 12/IA/1239 |
Revision History (Full details and data files)
- Version 1.0: 2020-09-30
Type: Initial release - Version 1.1: 2024-01-24
Changes: Data collection, Database references, Refinement description
