Identification of structural determinants of NAMPT activity and substrate selectivity
Houry, D., Raasakka, A., Kursula, P., Ziegler, M.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Nicotinamide phosphoribosyltransferase | 493 | Homo sapiens | Mutation(s): 0  Gene Names: NAMPT, PBEF, PBEF1 EC: 2.4.2.12 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P43490 (Homo sapiens) Explore P43490  Go to UniProtKB:  P43490 | |||||
PHAROS:  P43490 GTEx:  ENSG00000105835  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P43490 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 4 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
NMN (Subject of Investigation/LOI) Query on NMN | F [auth A], J [auth B] | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE C11 H16 N2 O8 P DAYLJWODMCOQEW-TURQNECASA-O | |||
PPV (Subject of Investigation/LOI) Query on PPV | G [auth A], K [auth B] | PYROPHOSPHATE H4 O7 P2 XPPKVPWEQAFLFU-UHFFFAOYSA-N | |||
GOL Query on GOL | C [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N | |||
MG (Subject of Investigation/LOI) Query on MG | D [auth A], E [auth A], H [auth B], I [auth B] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 61.017 | α = 90 |
b = 106.666 | β = 96.623 |
c = 83.549 | γ = 90 |
Software Name | Purpose |
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PHENIX | refinement |
XDS | data reduction |
Aimless | data scaling |
PHASER | phasing |
Funding Organization | Location | Grant Number |
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Research Council of Norway | Norway | 810882 |