Download MendeleyThe crystal Structures of Thermomyces (Humicola) lanuginosa lipase in complex with enzymatic reactants
McPherson, A., Larson, S.B., Kalasky, A.(2020) Current Enzyme Inhibition 16
6XOK
X-ray structure of the rhombohedral form of the lipase from Thermomyces lanuginosa at 1.3 A resolution
- PDB DOI: https://doi.org/10.2210/pdb6XOK/pdb
- Classification: LIPID BINDING PROTEIN
- Organism(s): Thermomyces lanuginosus
- Expression System: Aspergillus flavus
- Mutation(s): No
- Deposited: 2020-07-07 Released: 2020-10-14
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.30 Å
- R-Value Free: 0.134
- R-Value Work: 0.104
- R-Value Observed: 0.106
Starting Model: experimental
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This is version 1.2 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Lipase | 291 | Thermomyces lanuginosus | Mutation(s): 0 Gene Names: LIP EC: 3.1.1.3 |  | |
UniProt | |||||
Find proteins for O59952 (Thermomyces lanuginosus) Explore O59952 Go to UniProtKB: O59952 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | O59952 | ||||
Glycosylation | |||||
| Glycosylation Sites: 1 | |||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| LTV (Subject of Investigation/LOI) Query on LTV | J [auth A] | 2-hydroxy-3-(octadecanoyloxy)propyl pentacosanoate C46 H90 O5 XHUXLZVWHLYNKB-SJARJILFSA-N |  | ||
| NAG Query on NAG | B [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
| PG4 Query on PG4 | C [auth A] | TETRAETHYLENE GLYCOL C8 H18 O5 UWHCKJMYHZGTIT-UHFFFAOYSA-N |  | ||
| PO4 Query on PO4 | D [auth A] E [auth A] F [auth A] G [auth A] H [auth A] | PHOSPHATE ION O4 P NBIIXXVUZAFLBC-UHFFFAOYSA-K |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.30 Å
- R-Value Free: 0.134
- R-Value Work: 0.104
- R-Value Observed: 0.106
- Space Group: H 3 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 76.373 | α = 90 |
| b = 76.373 | β = 90 |
| c = 241.551 | γ = 120 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2020-10-14 Deposition Author(s): McPherson, A.
Revision History (Full details and data files)
- Version 1.0: 2020-10-14
Type: Initial release - Version 1.1: 2023-10-18
Changes: Advisory, Data collection, Database references, Refinement description - Version 1.2: 2024-10-16
Changes: Structure summary
