6Y7F

Crystal structure of human ELOVL fatty acid elongase 7 (ELOVL7)

PDB DOI: https://doi.org/10.2210/pdb6Y7F/pdb

Classification: TRANSFERASE
Organism(s): Homo sapiens
Expression System: Spodoptera frugiperda
Mutation(s): No
Membrane Protein: Yes OPMPDBTMmpstruc

Deposited: 2020-02-28 Released: 2020-05-13
Deposition Author(s): Nie, L., Pike, A.C.W., Bushell, S.R., Chu, A., Cole, V., Speedman, D., Rodstrom, K.E.J., Kupinska, K., Shrestha, L., Mukhopadhyay, S.M.M., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Funding Organization(s): European Commission, Wellcome Trust

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 2.05 Å
R-Value Free: 0.226
R-Value Work: 0.210
R-Value Observed: 0.211

wwPDB Validation 3D Report Full Report

Ligand Structure Quality Assessment

This is version 1.1 of the entry. See complete history.

Literature

Crystal structure of human ELOVL fatty acid elongase 7 (ELOVL7)

Nie, L., Pike, A.C.W., Bushell, S.R., Chu, A., Cole, V., Speedman, D., Kupinska, K., Shrestha, L., Mukhopadhyay, S.M.M., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P.

To be published.

Macromolecule Content

Total Structure Weight: 73.01 kDa
Atom Count: 4,665
Modelled Residue Count: 510
Deposited Residue Count: 576
Unique protein chains: 1

Macromolecules

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(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Elongation of very long chain fatty acids protein 7	A, B	288	Homo sapiens	Mutation(s): 0 Gene Names: ELOVL7 EC: 2.3.1.199 Membrane Entity: Yes
UniProt & NIH Common Fund Data Resources
Find proteins for A1L3X0 (Homo sapiens) Explore A1L3X0 Go to UniProtKB: A1L3X0
PHAROS: A1L3X0 GTEx: ENSG00000164181
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	A1L3X0
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 3 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
OFN (Subject of Investigation/LOI) Query on OFN Download Ideal Coordinates CCD File SDF format, chain C [auth A] SDF format, chain H [auth B] MOL2 format, chain C [auth A] MOL2 format, chain H [auth B] mmCIF format, chain C [auth A] mmCIF format, chain H [auth B]	C [auth A], H [auth B]	~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-oxidanylideneicosanethioate C₄₁ H₇₂ N₇ O₁₈ P₃ S FYBVHNZJDVUVLJ-IBYUJNRCSA-N		Interactions Focus chain C [auth A] Focus chain H [auth B] Interactions & Density Focus chain C [auth A] Focus chain H [auth B]
37X Query on 37X Download Ideal Coordinates CCD File SDF format, chain D [auth A] SDF format, chain E [auth A] SDF format, chain F [auth A] SDF format, chain I [auth B] MOL2 format, chain D [auth A] MOL2 format, chain E [auth A] MOL2 format, chain F [auth A] MOL2 format, chain I [auth B] mmCIF format, chain D [auth A] mmCIF format, chain E [auth A] mmCIF format, chain F [auth A] mmCIF format, chain I [auth B]	D [auth A], E [auth A], F [auth A], I [auth B]	Octyl Glucose Neopentyl Glycol C₂₇ H₅₂ O₁₂ TYXCLOLHZMMLEK-RNDJEAJNSA-N		Interactions Focus chain D [auth A] Focus chain E [auth A] Focus chain F [auth A] Focus chain I [auth B] Interactions & Density Focus chain D [auth A] Focus chain E [auth A] Focus chain F [auth A] Focus chain I [auth B]
CL Query on CL Download Ideal Coordinates CCD File SDF format, chain G [auth A] SDF format, chain J [auth B] MOL2 format, chain G [auth A] MOL2 format, chain J [auth B] mmCIF format, chain G [auth A] mmCIF format, chain J [auth B]	G [auth A], J [auth B]	CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M		Interactions Focus chain G [auth A] Focus chain J [auth B] Interactions & Density Focus chain G [auth A] Focus chain J [auth B]