Download MendeleyCrystal Structure of a human cyclic GMP-AMP synthase complex
Groebke-Zbinden, K., Vandemeulebroucke, A., Hilbert, M., Rudolph, M.G.To be published.
7FTG
Crystal Structure of human cyclic GMP-AMP synthase in complex with cGAMP
- PDB DOI: https://doi.org/10.2210/pdb7FTG/pdb
- Deposition Group: G_1002263 ExploreG_1002263
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2023-02-08 Released: 2024-02-21
- Funding Organization(s): F. Hoffmann-La Roche LTD
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.73 Å
- R-Value Free: 0.230
- R-Value Work: 0.192
- R-Value Observed: 0.193
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Cyclic GMP-AMP synthase | 362 | Homo sapiens | Mutation(s): 0 Gene Names: CGAS, C6orf150, MB21D1 EC: 2.7.7.86 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8N884 (Homo sapiens) Explore Q8N884 Go to UniProtKB: Q8N884 | |||||
PHAROS: Q8N884 GTEx: ENSG00000164430 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8N884 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 1SY (Subject of Investigation/LOI) Query on 1SY | C [auth A], E [auth B] | cGAMP C20 H24 N10 O13 P2 XRILCFTWUCUKJR-INFSMZHSSA-N |  | ||
| ZN Query on ZN | D [auth A], F [auth B] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.73 Å
- R-Value Free: 0.230
- R-Value Work: 0.192
- R-Value Observed: 0.193
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 48.09 | α = 90 |
| b = 118.34 | β = 90 |
| c = 125.15 | γ = 90 |
| Software Name | Purpose |
|---|---|
| XSCALE | data scaling |
| PHENIX | refinement |
| PDB_EXTRACT | data extraction |
| XDS | data reduction |
| XSCALE | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-02-21 Deposition Author(s): Leibrock, L., Benz, J., Groebke-Zbinden, K., Rudolph, M.G.
| Funding Organization | Location | Grant Number |
|---|---|---|
| F. Hoffmann-La Roche LTD | Switzerland | -- |
Revision History (Full details and data files)
- Version 1.0: 2024-02-21
Type: Initial release
