Download MendeleyCrystal structure of Q108K:K40L:T51V:T53C:R58W:T29L:Y19W:Q4A mutant of cellular retinol binding protein II complex with all-trans-retinal after exposure to visible light
Ehyaei, N., Geiger, J.H., Borhan, B.To be published.
7LHN
Crystal structure of Q108K:K40L:T51V:T53C:R58W:T29L:Y19W:Q4A mutant of cellular retinol binding protein II complex with all-trans-retinal after exposure to visible light
- PDB DOI: https://doi.org/10.2210/pdb7LHN/pdb
- Classification: CYTOSOLIC PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2021-01-25 Released: 2021-04-14
- Funding Organization(s): National Institutes of Health/National Center for Research Resources (NIH/NCRR)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.11 Å
- R-Value Free: 0.264
- R-Value Work: 0.172
- R-Value Observed: 0.181
Starting Model: experimental
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This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Retinol-binding protein 2 | 133 | Homo sapiens | Mutation(s): 8 Gene Names: RBP2, CRBP2 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P50120 (Homo sapiens) Explore P50120 Go to UniProtKB: P50120 | |||||
PHAROS: P50120 GTEx: ENSG00000114113 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P50120 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| RET (Subject of Investigation/LOI) Query on RET | D [auth A], E [auth B] | RETINAL C20 H28 O NCYCYZXNIZJOKI-OVSJKPMPSA-N |  | ||
| GOL Query on GOL | C [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.11 Å
- R-Value Free: 0.264
- R-Value Work: 0.172
- R-Value Observed: 0.181
- Space Group: P 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 30.755 | α = 86.18 |
| b = 35.773 | β = 86.478 |
| c = 64.153 | γ = 65.224 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data scaling |
| PDB_EXTRACT | data extraction |
| HKL-2000 | data reduction |
| Coot | model building |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2021-04-14 Deposition Author(s): Ehyaei, N., Geiger, J.H., Borhan, B.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Center for Research Resources (NIH/NCRR) | United States | -- |
Revision History (Full details and data files)
- Version 1.0: 2021-04-14
Type: Initial release - Version 1.1: 2023-10-18
Changes: Advisory, Data collection, Database references, Refinement description - Version 1.2: 2024-10-30
Changes: Structure summary
