Structural basis of CBP and EP300 interaction with kinase inhibitors
Schonbrunn, E., Bikowitz, M.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Histone acetyltransferase | 116 | Homo sapiens | Mutation(s): 0  Gene Names: CREBBP EC: 2.3.1.48 (PDB Primary Data), 2.3.1 (UniProt) | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q92793 (Homo sapiens) Explore Q92793  Go to UniProtKB:  Q92793 | |||||
PHAROS:  Q92793 GTEx:  ENSG00000005339  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q92793 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 2 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
N6I (Subject of Investigation/LOI) Query on N6I | C [auth A], D [auth B] | (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one C25 H26 Cl N5 O3 ZWVZORIKUNOTCS-OAQYLSRUSA-N | |||
EDO Query on EDO | E [auth B] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 43.122 | α = 90 |
b = 59.293 | β = 109.81 |
c = 57.147 | γ = 90 |
Software Name | Purpose |
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PHENIX | refinement |
PDB_EXTRACT | data extraction |
HKL-2000 | data reduction |
HKL-2000 | data scaling |
PHENIX | phasing |
Funding Organization | Location | Grant Number |
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Not funded | -- |