Structural basis of CBP and EP300 interaction with kinase inhibitors
Schonbrunn, E., Bikowitz, M.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
Bromodomain-containing protein 4 | 127 | Homo sapiens | Mutation(s): 0  Gene Names: BRD4, HUNK1 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O60885 (Homo sapiens) Explore O60885  Go to UniProtKB:  O60885 | |||||
PHAROS:  O60885 GTEx:  ENSG00000141867  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | O60885 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 2 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
N6I (Subject of Investigation/LOI) Query on N6I | B [auth A] | (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one C25 H26 Cl N5 O3 ZWVZORIKUNOTCS-OAQYLSRUSA-N | |||
EDO Query on EDO | C [auth A], D [auth A], E [auth A], F [auth A], G [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 37.4 | α = 90 |
b = 44.26 | β = 90 |
c = 78.64 | γ = 90 |
Software Name | Purpose |
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PHENIX | refinement |
PDB_EXTRACT | data extraction |
XDS | data reduction |
XSCALE | data scaling |
PHENIX | phasing |
Funding Organization | Location | Grant Number |
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Not funded | -- |