Download MendeleyCrystal structure of human GCN5 histone acetyltransferase domain
Lu, X.T., Tao, Y.J.To be published.
8E6O
Crystal structure of human GCN5 histone acetyltransferase domain
- PDB DOI: https://doi.org/10.2210/pdb8E6O/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2022-08-23 Released: 2024-02-28
- Funding Organization(s): Robert A. Welch Foundation
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.37 Å
- R-Value Free: 0.242
- R-Value Work: 0.205
- R-Value Observed: 0.207
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Histone acetyltransferase KAT2A | 165 | Homo sapiens | Mutation(s): 0 Gene Names: KAT2A, GCN5, GCN5L2 EC: 2.3.1.48 (PDB Primary Data), 2.3.1 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q92830 (Homo sapiens) Explore Q92830 Go to UniProtKB: Q92830 | |||||
PHAROS: Q92830 GTEx: ENSG00000108773 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q92830 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| UQ3 (Subject of Investigation/LOI) Query on UQ3 | D [auth A], E [auth B], F [auth C] | S-{(3S,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5,10,14-tetraoxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (2R)-2-hydroxypropanethioate C24 H40 N7 O18 P3 S VIWKEBOLLIEAIL-AGCMQPJKSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.37 Å
- R-Value Free: 0.242
- R-Value Work: 0.205
- R-Value Observed: 0.207
- Space Group: I 4 2 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 137.889 | α = 90 |
| b = 137.889 | β = 90 |
| c = 154.875 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
| Funding Organization | Location | Grant Number |
|---|---|---|
| Robert A. Welch Foundation | United States | C-1565 |
Revision History (Full details and data files)
- Version 1.0: 2024-02-28
Type: Initial release
