Download MendeleyStructure-Guided Design of HsRNMT inhibitors
Petit, A.P., Fyfe, P.K.To be published.
8Q9W
Crystal structure of HsRNMT complexed with sinefungin and GMP-PnP
- PDB DOI: https://doi.org/10.2210/pdb8Q9W/pdb
- Classification: RNA BINDING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2023-08-21 Released: 2024-09-11
- Funding Organization(s): Not funded
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.50 Å
- R-Value Free: 0.229
- R-Value Work: 0.174
- R-Value Observed: 0.177
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| mRNA cap guanine-N7 methyltransferase | 276 | Homo sapiens | Mutation(s): 0 Gene Names: RNMT, KIAA0398 EC: 2.1.1.56 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O43148 (Homo sapiens) Explore O43148 Go to UniProtKB: O43148 | |||||
PHAROS: O43148 GTEx: ENSG00000101654 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | O43148 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GNP (Subject of Investigation/LOI) Query on GNP | F [auth B] | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER C10 H17 N6 O13 P3 UQABYHGXWYXDTK-UUOKFMHZSA-N |  | ||
| SFG (Subject of Investigation/LOI) Query on SFG | C [auth A], E [auth B] | SINEFUNGIN C15 H23 N7 O5 LMXOHSDXUQEUSF-YECHIGJVSA-N |  | ||
| SO4 Query on SO4 | D [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.50 Å
- R-Value Free: 0.229
- R-Value Work: 0.174
- R-Value Observed: 0.177
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 40.463 | α = 90 |
| b = 84.086 | β = 99.67 |
| c = 85.344 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| SCALA | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-09-11 Deposition Author(s): Petit, A.P., Fyfe, P.K.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Not funded | United Kingdom | -- |
Revision History (Full details and data files)
- Version 1.0: 2024-09-11
Type: Initial release
