8BEM

Deposited: 2022-10-21 Released: 2022-11-09
Deposition Author(s): Kraemer, A., Knapp, S., Structural Genomics Consortium (SGC)
Funding Organization(s): The Structural Genomics Consortium (SGC)

Experimental Data Snapshot

Starting Model: experimental
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wwPDB Validation 3D Report Full Report

Ligand Structure Quality Assessment

This is version 1.1 of the entry. See complete history.

Literature

Macromolecule Content

Macromolecules

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(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
STE20-like serine/threonine-protein kinase	A, B, C [auth D], D [auth G]	303	Homo sapiens	Mutation(s): 0 Gene Names: SLK, KIAA0204, STK2 EC: 2.7.11.1
UniProt & NIH Common Fund Data Resources
Find proteins for Q9H2G2 (Homo sapiens) Explore Q9H2G2 Go to UniProtKB: Q9H2G2
PHAROS: Q9H2G2 GTEx: ENSG00000065613
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q9H2G2
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 2 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
AV9 (Subject of Investigation/LOI) Query on AV9 Download Ideal Coordinates CCD File SDF format, chain E [auth A] SDF format, chain G [auth B] SDF format, chain H [auth D] SDF format, chain J [auth G] MOL2 format, chain E [auth A] MOL2 format, chain G [auth B] MOL2 format, chain H [auth D] MOL2 format, chain J [auth G] mmCIF format, chain E [auth A] mmCIF format, chain G [auth B] mmCIF format, chain H [auth D] mmCIF format, chain J [auth G]	E [auth A], G [auth B], H [auth D], J [auth G]	TIVOZANIB C₂₂ H₁₉ Cl N₄ O₅ SPMVMDHWKHCIDT-UHFFFAOYSA-N		Interactions Focus chain E [auth A] Focus chain G [auth B] Focus chain H [auth D] Focus chain J [auth G] Interactions & Density Focus chain E [auth A] Focus chain G [auth B] Focus chain H [auth D] Focus chain J [auth G]
SO4 Query on SO4 Download Ideal Coordinates CCD File SDF format, chain F [auth A] SDF format, chain I [auth D] SDF format, chain K [auth G] MOL2 format, chain F [auth A] MOL2 format, chain I [auth D] MOL2 format, chain K [auth G] mmCIF format, chain F [auth A] mmCIF format, chain I [auth D] mmCIF format, chain K [auth G]	F [auth A], I [auth D], K [auth G]	SULFATE ION O₄ S QAOWNCQODCNURD-UHFFFAOYSA-L		Interactions Focus chain F [auth A] Focus chain I [auth D] Focus chain K [auth G] Interactions & Density Focus chain F [auth A] Focus chain I [auth D] Focus chain K [auth G]