9DFE

Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin and protein Y at 2.60A resolution

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.60 Å
  • R-Value Free: 0.252 
  • R-Value Work: 0.202 
  • R-Value Observed: 0.204 

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This is version 1.0 of the entry. See complete history. 


Literature

A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial Ribosome.

Wright, G., Jangra, M., Travin, D., Aleksandrova, E., Kaur, M., Darwish, L., Koteva, K., Klepacki, D., Wang, W., Tiffany, M., Sokaribo, A., Coombes, B., Vazquez-Laslop, N., Polikanov, Y., Mankin, A.

(2024) Res Sq 

  • DOI: https://doi.org/10.21203/rs.3.rs-5058118/v1
  • Primary Citation of Related Structures:  
    9DFC, 9DFD, 9DFE

  • PubMed Abstract: 

    Lasso peptides, biologically active molecules with a distinct structurally constrained knotted fold, are natural products belonging to the class of ribosomally-synthesized and posttranslationally modified peptides (RiPPs). Lasso peptides act upon several bacterial targets, but none have been reported to inhibit the ribosome, one of the main antibiotic targets in the bacterial cell. Here, we report the identification and characterization of the lasso peptide antibiotic, lariocidin (LAR), and its internally cyclized derivative, lariocidin B (LAR-B), produced by Paenabacillussp . M2, with broad-spectrum activity against many bacterial pathogens. We show that lariocidins inhibit bacterial growth by binding to the ribosome and interfering with protein synthesis. Structural, genetic, and biochemical data show that lariocidins bind at a unique site in the small ribosomal subunit, where they interact with the 16S rRNA and aminoacyl-tRNA, inhibiting translocation and inducing miscoding. LAR is unaffected by common resistance mechanisms, has a low propensity for generating spontaneous resistance, shows no human cell toxicity, and has potent in vivo activity in a mouse model of Acinetobacter baumannii infection. Our finding of the first ribosome-targeting lasso peptides uncovers new routes toward discovering alternative protein synthesis inhibitors and offers a new chemical scaffold for developing much-needed antibacterial drugs.

    • Organizational Affiliation: 

    McMaster University.


Macromolecules

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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L2C [auth 1D],
EB [auth 2D]		276Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L3D [auth 1E],
FB [auth 2E]		206Thermus thermophilus HB8Mutation(s): 0 
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Find proteins for Q5SHN8 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L4E [auth 1F],
GB [auth 2F]		210Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L5F [auth 1G],
HB [auth 2G]		182Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L6G [auth 1H],
IB [auth 2H]		180Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L9H [auth 1I],
JB [auth 2I]		148Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L13I [auth 1N],
KB [auth 2N]		140Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L14J [auth 1O],
LB [auth 2O]		122Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L15K [auth 1P],
MB [auth 2P]		150Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L16L [auth 1Q],
NB [auth 2Q]		141Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L17M [auth 1R],
OB [auth 2R]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L18N [auth 1S],
PB [auth 2S]		112Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L19O [auth 1T],
QB [auth 2T]		146Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L20P [auth 1U],
RB [auth 2U]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L21Q [auth 1V],
SB [auth 2V]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L22R [auth 1W],
TB [auth 2W]		113Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L23S [auth 1X],
UB [auth 2X]		96Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L24T [auth 1Y],
VB [auth 2Y]		110Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L25U [auth 1Z],
WB [auth 2Z]		206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 22
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L27V [auth 10],
XB [auth 20]		85Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 23
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L28W [auth 11],
YB [auth 21]		98Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L29X [auth 12],
ZB [auth 22]		72Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 25
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L30AC [auth 23],
Y [auth 13]		60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L31BC [auth 24],
Z [auth 14]		71Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L32AA [auth 15],
CC [auth 25]		60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L33BA [auth 16],
DC [auth 26]		54Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L34CA [auth 17],
EC [auth 27]		49Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L35DA [auth 18],
FC [auth 28]		65Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 31
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L36EA [auth 19],
GC [auth 29]		37Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S2GA [auth 1b],
IC [auth 2b]		256Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 34
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S3HA [auth 1c],
JC [auth 2c]		239Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S4IA [auth 1d],
KC [auth 2d]		209Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S5JA [auth 1e],
LC [auth 2e]		162Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S6KA [auth 1f],
MC [auth 2f]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S7LA [auth 1g],
NC [auth 2g]		156Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S8MA [auth 1h],
OC [auth 2h]		138Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S9NA [auth 1i],
PC [auth 2i]		128Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S10OA [auth 1j],
QC [auth 2j]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S11PA [auth 1k],
RC [auth 2k]		129Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S12QA [auth 1l],
SC [auth 2l]		132Thermus thermophilus HB8Mutation(s): 0 
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UniProt GroupQ5SHN3
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S13RA [auth 1m],
TC [auth 2m]		126Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S14 type ZSA [auth 1n],
UC [auth 2n]		61Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for P0DOY6 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S15TA [auth 1o],
VC [auth 2o]		89Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SJ76 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S16UA [auth 1p],
WC [auth 2p]		88Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SJH3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S17VA [auth 1q],
XC [auth 2q]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S18WA [auth 1r],
YC [auth 2r]		88Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for Q5SLQ0 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S19XA [auth 1s],
ZC [auth 2s]		93Thermus thermophilus HB8Mutation(s): 0 
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Find proteins for Q5SHP2 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S20AD [auth 2t],
YA [auth 1t]		106Thermus thermophilus HB8Mutation(s): 0 
UniProt
Find proteins for P80380 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein ThxBD [auth 2u],
ZA [auth 1u]		27Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 53
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosome-associated inhibitor AAB [auth 1y],
CD [auth 2y]		113Escherichia coli K-12Mutation(s): 0 
Gene Names: raiA, yfiA, b2597, JW2578
UniProt
Find proteins for P0AD49 (Escherichia coli (strain K12))
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Entity ID: 54
MoleculeChains Sequence LengthOrganismDetailsImage
Lasso peptide lariocidinBB [auth 1z],
DD [auth 2z]		18PaenibacillusMutation(s): 0 
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Entity ID: 1
MoleculeChains LengthOrganismImage
23S Ribosomal RNAA [auth 1A],
CB [auth 2A]		2,915Thermus thermophilus HB8
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Entity ID: 2
MoleculeChains LengthOrganismImage
5S Ribosomal RNAB [auth 1B],
DB [auth 2B]		121Thermus thermophilus HB8
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Entity ID: 32
MoleculeChains LengthOrganismImage
16S Ribosomal RNAFA [auth 1a],
HC [auth 2a]		1,521Thermus thermophilus HB8
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Small Molecules
Ligands 5 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
SF4
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BIB [auth 1d],
IWC [auth 2d]		IRON/SULFUR CLUSTER
Fe4 S4
LJBDFODJNLIPKO-UHFFFAOYSA-N
ARG
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VRA [auth 1B]ARGININE
C6 H15 N4 O2
ODKSFYDXXFIFQN-BYPYZUCNSA-O
MPD
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AXA [auth 18],
TLC [auth 2A],
XUA [auth 1T]		(4S)-2-METHYL-2,4-PENTANEDIOL
C6 H14 O2
SVTBMSDMJJWYQN-YFKPBYRVSA-N
ZN
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DXA [auth 19]
IOC [auth 2Y]
IWA [auth 14]
NOC [auth 24]
PWC [auth 2n]
DXA [auth 19],
IOC [auth 2Y],
IWA [auth 14],
NOC [auth 24],
PWC [auth 2n],
ROC [auth 25],
RVA [auth 1Y],
RWA [auth 15],
SOC [auth 26],
SWA [auth 16],
TIB [auth 1n],
WOC [auth 29]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
MG
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AAA [auth 1A]
AAB [auth 1a]
AAC [auth 2A]
ABA [auth 1A]
ABB [auth 1a]
AAA [auth 1A],
AAB [auth 1a],
AAC [auth 2A],
ABA [auth 1A],
ABB [auth 1a],
ABC [auth 2A],
ACA [auth 1A],
ACB [auth 1a],
ACC [auth 2A],
ADA [auth 1A],
ADB [auth 1a],
ADC [auth 2A],
AE [auth 1A],
AEA [auth 1A],
AEB [auth 1a],
AEC [auth 2A],
AF [auth 1A],
AFA [auth 1A],
AFB [auth 1a],
AFC [auth 2A],
AG [auth 1A],
AGA [auth 1A],
AGB [auth 1a],
AGC [auth 2A],
AH [auth 1A],
AHA [auth 1A],
AHB [auth 1a],
AHC [auth 2A],
AI [auth 1A],
AIA [auth 1A],
AIB [auth 1d],
AIC [auth 2A],
AJ [auth 1A],
AJA [auth 1A],
AJB [auth 1y],
AJC [auth 2A],
AK [auth 1A],
AKA [auth 1A],
AKB [auth 2A],
AKC [auth 2A],
AL [auth 1A],
ALA [auth 1A],
ALB [auth 2A],
ALC [auth 2A],
AM [auth 1A],
AMA [auth 1A],
AMB [auth 2A],
AMC [auth 2B],
AN [auth 1A],
ANA [auth 1A],
ANB [auth 2A],
ANC [auth 2E],
AO [auth 1A],
AOA [auth 1A],
AOB [auth 2A],
AOC [auth 2T],
AP [auth 1A],
APA [auth 1A],
APB [auth 2A],
APC [auth 2a],
AQ [auth 1A],
AQA [auth 1A],
AQB [auth 2A],
AQC [auth 2a],
AR [auth 1A],
ARA [auth 1B],
ARB [auth 2A],
ARC [auth 2a],
AS [auth 1A],
ASA [auth 1D],
ASB [auth 2A],
ASC [auth 2a],
AT [auth 1A],
ATA [auth 1F],
ATB [auth 2A],
ATC [auth 2a],
AU [auth 1A],
AUA [auth 1N],
AUB [auth 2A],
AUC [auth 2a],
AV [auth 1A],
AVA [auth 1U],
AVB [auth 2A],
AVC [auth 2a],
AW [auth 1A],
AWA [auth 11],
AWB [auth 2A],
AWC [auth 2a],
AX [auth 1A],
AXB [auth 2A],
AY [auth 1A],
AYA [auth 1a],
AYB [auth 2A],
AZ [auth 1A],
AZA [auth 1a],
AZB [auth 2A],
BAA [auth 1A],
BAB [auth 1a],
BAC [auth 2A],
BBA [auth 1A],
BBB [auth 1a],
BBC [auth 2A],
BCA [auth 1A],
BCB [auth 1a],
BCC [auth 2A],
BDA [auth 1A],
BDB [auth 1a],
BDC [auth 2A],
BE [auth 1A],
BEA [auth 1A],
BEB [auth 1a],
BEC [auth 2A],
BF [auth 1A],
BFA [auth 1A],
BFB [auth 1a],
BFC [auth 2A],
BG [auth 1A],
BGA [auth 1A],
BGB [auth 1a],
BGC [auth 2A],
BH [auth 1A],
BHA [auth 1A],
BHB [auth 1a],
BHC [auth 2A],
BI [auth 1A],
BIA [auth 1A],
BIC [auth 2A],
BJ [auth 1A],
BJA [auth 1A],
BJB [auth 1z],
BJC [auth 2A],
BK [auth 1A],
BKA [auth 1A],
BKB [auth 2A],
BKC [auth 2A],
BL [auth 1A],
BLA [auth 1A],
BLB [auth 2A],
BLC [auth 2A],
BM [auth 1A],
BMA [auth 1A],
BMB [auth 2A],
BMC [auth 2B],
BN [auth 1A],
BNA [auth 1A],
BNB [auth 2A],
BNC [auth 2E],
BO [auth 1A],
BOA [auth 1A],
BOB [auth 2A],
BOC [auth 2T],
BP [auth 1A],
BPA [auth 1A],
BPB [auth 2A],
BPC [auth 2a],
BQ [auth 1A],
BQA [auth 1A],
BQB [auth 2A],
BQC [auth 2a],
BR [auth 1A],
BRA [auth 1B],
BRB [auth 2A],
BRC [auth 2a],
BS [auth 1A],
BSA [auth 1D],
BSB [auth 2A],
BSC [auth 2a],
BT [auth 1A],
BTA [auth 1F],
BTB [auth 2A],
BTC [auth 2a],
BU [auth 1A],
BUA [auth 1O],
BUB [auth 2A],
BUC [auth 2a],
BV [auth 1A],
BVA [auth 1U],
BVB [auth 2A],
BVC [auth 2a],
BW [auth 1A],
BWA [auth 11],
BWB [auth 2A],
BWC [auth 2a],
BX [auth 1A],
BXA [auth 19],
BXB [auth 2A],
BY [auth 1A],
BYA [auth 1a],
BYB [auth 2A],
BZ [auth 1A],
BZA [auth 1a],
BZB [auth 2A],
CAA [auth 1A],
CAB [auth 1a],
CAC [auth 2A],
CBA [auth 1A],
CBB [auth 1a],
CBC [auth 2A],
CCA [auth 1A],
CCB [auth 1a],
CCC [auth 2A],
CDA [auth 1A],
CDB [auth 1a],
CDC [auth 2A],
CE [auth 1A],
CEA [auth 1A],
CEB [auth 1a],
CEC [auth 2A],
CF [auth 1A],
CFA [auth 1A],
CFB [auth 1a],
CFC [auth 2A],
CG [auth 1A],
CGA [auth 1A],
CGB [auth 1a],
CGC [auth 2A],
CH [auth 1A],
CHA [auth 1A],
CHB [auth 1a],
CHC [auth 2A],
CI [auth 1A],
CIA [auth 1A],
CIB [auth 1e],
CIC [auth 2A],
CJ [auth 1A],
CJA [auth 1A],
CJB [auth 2A],
CJC [auth 2A],
CK [auth 1A],
CKA [auth 1A],
CKB [auth 2A],
CKC [auth 2A],
CL [auth 1A],
CLA [auth 1A],
CLB [auth 2A],
CLC [auth 2A],
CM [auth 1A],
CMA [auth 1A],
CMB [auth 2A],
CMC [auth 2B],
CN [auth 1A],
CNA [auth 1A],
CNB [auth 2A],
CNC [auth 2E],
CO [auth 1A],
COA [auth 1A],
COB [auth 2A],
COC [auth 2V],
CP [auth 1A],
CPA [auth 1A],
CPB [auth 2A],
CPC [auth 2a],
CQ [auth 1A],
CQA [auth 1A],
CQB [auth 2A],
CQC [auth 2a],
CR [auth 1A],
CRA [auth 1B],
CRB [auth 2A],
CRC [auth 2a],
CS [auth 1A],
CSA [auth 1D],
CSB [auth 2A],
CSC [auth 2a],
CT [auth 1A],
CTA [auth 1F],
CTB [auth 2A],
CTC [auth 2a],
CU [auth 1A],
CUA [auth 1P],
CUB [auth 2A],
CUC [auth 2a],
CV [auth 1A],
CVA [auth 1U],
CVB [auth 2A],
CVC [auth 2a],
CW [auth 1A],
CWA [auth 11],
CWB [auth 2A],
CWC [auth 2a],
CX [auth 1A],
CXA [auth 19],
CXB [auth 2A],
CY [auth 1A],
CYA [auth 1a],
CYB [auth 2A],
CZ [auth 1A],
CZA [auth 1a],
CZB [auth 2A],
DAA [auth 1A],
DAB [auth 1a],
DAC [auth 2A],
DBA [auth 1A],
DBB [auth 1a],
DBC [auth 2A],
DCA [auth 1A],
DCB [auth 1a],
DCC [auth 2A],
DDA [auth 1A],
DDB [auth 1a],
DDC [auth 2A],
DE [auth 1A],
DEA [auth 1A],
DEB [auth 1a],
DEC [auth 2A],
DF [auth 1A],
DFA [auth 1A],
DFB [auth 1a],
DFC [auth 2A],
DG [auth 1A],
DGA [auth 1A],
DGB [auth 1a],
DGC [auth 2A],
DH [auth 1A],
DHA [auth 1A],
DHB [auth 1a],
DHC [auth 2A],
DI [auth 1A],
DIA [auth 1A],
DIB [auth 1e],
DIC [auth 2A],
DJ [auth 1A],
DJA [auth 1A],
DJB [auth 2A],
DJC [auth 2A],
DK [auth 1A],
DKA [auth 1A],
DKB [auth 2A],
DKC [auth 2A],
DL [auth 1A],
DLA [auth 1A],
DLB [auth 2A],
DLC [auth 2A],
DM [auth 1A],
DMA [auth 1A],
DMB [auth 2A],
DMC [auth 2B],
DN [auth 1A],
DNA [auth 1A],
DNB [auth 2A],
DNC [auth 2E],
DO [auth 1A],
DOA [auth 1A],
DOB [auth 2A],
DOC [auth 2V],
DP [auth 1A],
DPA [auth 1A],
DPB [auth 2A],
DPC [auth 2a],
DQ [auth 1A],
DQA [auth 1A],
DQB [auth 2A],
DQC [auth 2a],
DR [auth 1A],
DRA [auth 1B],
DRB [auth 2A],
DRC [auth 2a],
DS [auth 1A],
DSA [auth 1D],
DSB [auth 2A],
DSC [auth 2a],
DT [auth 1A],
DTA [auth 1F],
DTB [auth 2A],
DTC [auth 2a],
DU [auth 1A],
DUA [auth 1P],
DUB [auth 2A],
DUC [auth 2a],
DV [auth 1A],
DVA [auth 1U],
DVB [auth 2A],
DVC [auth 2a],
DW [auth 1A],
DWA [auth 11],
DWB [auth 2A],
DWC [auth 2a],
DX [auth 1A],
DXB [auth 2A],
DY [auth 1A],
DYA [auth 1a],
DYB [auth 2A],
DZ [auth 1A],
DZA [auth 1a],
DZB [auth 2A],
EAA [auth 1A],
EAB [auth 1a],
EAC [auth 2A],
EBA [auth 1A],
EBB [auth 1a],
EBC [auth 2A],
ECA [auth 1A],
ECB [auth 1a],
ECC [auth 2A],
ED [auth 1A],
EDA [auth 1A],
EDB [auth 1a],
EDC [auth 2A],
EE [auth 1A],
EEA [auth 1A],
EEB [auth 1a],
EEC [auth 2A],
EF [auth 1A],
EFA [auth 1A],
EFB [auth 1a],
EFC [auth 2A],
EG [auth 1A],
EGA [auth 1A],
EGB [auth 1a],
EGC [auth 2A],
EH [auth 1A],
EHA [auth 1A],
EHB [auth 1a],
EHC [auth 2A],
EI [auth 1A],
EIA [auth 1A],
EIB [auth 1e],
EIC [auth 2A],
EJ [auth 1A],
EJA [auth 1A],
EJB [auth 2A],
EJC [auth 2A],
EK [auth 1A],
EKA [auth 1A],
EKB [auth 2A],
EKC [auth 2A],
EL [auth 1A],
ELA [auth 1A],
ELB [auth 2A],
ELC [auth 2A],
EM [auth 1A],
EMA [auth 1A],
EMB [auth 2A],
EMC [auth 2B],
EN [auth 1A],
ENA [auth 1A],
ENB [auth 2A],
ENC [auth 2E],
EO [auth 1A],
EOA [auth 1A],
EOB [auth 2A],
EOC [auth 2V],
EP [auth 1A],
EPA [auth 1A],
EPB [auth 2A],
EPC [auth 2a],
EQ [auth 1A],
EQA [auth 1A],
EQB [auth 2A],
EQC [auth 2a],
ER [auth 1A],
ERA [auth 1B],
ERB [auth 2A],
ERC [auth 2a],
ES [auth 1A],
ESA [auth 1D],
ESB [auth 2A],
ESC [auth 2a],
ET [auth 1A],
ETA [auth 1F],
ETB [auth 2A],
ETC [auth 2a],
EU [auth 1A],
EUA [auth 1P],
EUB [auth 2A],
EUC [auth 2a],
EV [auth 1A],
EVA [auth 1U],
EVB [auth 2A],
EVC [auth 2a],
EW [auth 1A],
EWA [auth 11],
EWB [auth 2A],
EWC [auth 2a],
EX [auth 1A],
EXA [auth 1a],
EXB [auth 2A],
EY [auth 1A],
EYA [auth 1a],
EYB [auth 2A],
EZ [auth 1A],
EZA [auth 1a],
EZB [auth 2A],
FAA [auth 1A],
FAB [auth 1a],
FAC [auth 2A],
FBA [auth 1A],
FBB [auth 1a],
FBC [auth 2A],
FCA [auth 1A],
FCB [auth 1a],
FCC [auth 2A],
FD [auth 1A],
FDA [auth 1A],
FDB [auth 1a],
FDC [auth 2A],
FE [auth 1A],
FEA [auth 1A],
FEB [auth 1a],
FEC [auth 2A],
FF [auth 1A],
FFA [auth 1A],
FFB [auth 1a],
FFC [auth 2A],
FG [auth 1A],
FGA [auth 1A],
FGB [auth 1a],
FGC [auth 2A],
FH [auth 1A],
FHA [auth 1A],
FHB [auth 1a],
FHC [auth 2A],
FI [auth 1A],
FIA [auth 1A],
FIB [auth 1e],
FIC [auth 2A],
FJ [auth 1A],
FJA [auth 1A],
FJB [auth 2A],
FJC [auth 2A],
FK [auth 1A],
FKA [auth 1A],
FKB [auth 2A],
FKC [auth 2A],
FL [auth 1A],
FLA [auth 1A],
FLB [auth 2A],
FLC [auth 2A],
FM [auth 1A],
FMA [auth 1A],
FMB [auth 2A],
FMC [auth 2B],
FN [auth 1A],
FNA [auth 1A],
FNB [auth 2A],
FNC [auth 2E],
FO [auth 1A],
FOA [auth 1A],
FOB [auth 2A],
FOC [auth 2W],
FP [auth 1A],
FPA [auth 1A],
FPB [auth 2A],
FPC [auth 2a],
FQ [auth 1A],
FQA [auth 1A],
FQB [auth 2A],
FQC [auth 2a],
FR [auth 1A],
FRA [auth 1B],
FRB [auth 2A],
FRC [auth 2a],
FS [auth 1A],
FSA [auth 1D],
FSB [auth 2A],
FSC [auth 2a],
FT [auth 1A],
FTA [auth 1F],
FTB [auth 2A],
FTC [auth 2a],
FU [auth 1A],
FUA [auth 1P],
FUB [auth 2A],
FUC [auth 2a],
FV [auth 1A],
FVA [auth 1U],
FVB [auth 2A],
FVC [auth 2a],
FW [auth 1A],
FWA [auth 13],
FWB [auth 2A],
FWC [auth 2a],
FX [auth 1A],
FXA [auth 1a],
FXB [auth 2A],
FY [auth 1A],
FYA [auth 1a],
FYB [auth 2A],
FZ [auth 1A],
FZA [auth 1a],
FZB [auth 2A],
GAA [auth 1A],
GAB [auth 1a],
GAC [auth 2A],
GBA [auth 1A],
GBB [auth 1a],
GBC [auth 2A],
GCA [auth 1A],
GCB [auth 1a],
GCC [auth 2A],
GD [auth 1A],
GDA [auth 1A],
GDB [auth 1a],
GDC [auth 2A],
GE [auth 1A],
GEA [auth 1A],
GEB [auth 1a],
GEC [auth 2A],
GF [auth 1A],
GFA [auth 1A],
GFB [auth 1a],
GFC [auth 2A],
GG [auth 1A],
GGA [auth 1A],
GGB [auth 1a],
GGC [auth 2A],
GH [auth 1A],
GHA [auth 1A],
GHB [auth 1a],
GHC [auth 2A],
GI [auth 1A],
GIA [auth 1A],
GIB [auth 1e],
GIC [auth 2A],
GJ [auth 1A],
GJA [auth 1A],
GJB [auth 2A],
GJC [auth 2A],
GK [auth 1A],
GKA [auth 1A],
GKB [auth 2A],
GKC [auth 2A],
GL [auth 1A],
GLA [auth 1A],
GLB [auth 2A],
GLC [auth 2A],
GM [auth 1A],
GMA [auth 1A],
GMB [auth 2A],
GMC [auth 2B],
GN [auth 1A],
GNA [auth 1A],
GNB [auth 2A],
GNC [auth 2E],
GO [auth 1A],
GOA [auth 1A],
GOB [auth 2A],
GOC [auth 2W],
GP [auth 1A],
GPA [auth 1A],
GPB [auth 2A],
GPC [auth 2a],
GQ [auth 1A],
GQA [auth 1A],
GQB [auth 2A],
GQC [auth 2a],
GR [auth 1A],
GRA [auth 1B],
GRB [auth 2A],
GRC [auth 2a],
GS [auth 1A],
GSA [auth 1D],
GSB [auth 2A],
GSC [auth 2a],
GT [auth 1A],
GTA [auth 1F],
GTB [auth 2A],
GTC [auth 2a],
GU [auth 1A],
GUA [auth 1P],
GUB [auth 2A],
GUC [auth 2a],
GV [auth 1A],
GVA [auth 1V],
GVB [auth 2A],
GVC [auth 2a],
GW [auth 1A],
GWA [auth 13],
GWB [auth 2A],
GWC [auth 2a],
GX [auth 1A],
GXA [auth 1a],
GXB [auth 2A],
GY [auth 1A],
GYA [auth 1a],
GYB [auth 2A],
GZ [auth 1A],
GZA [auth 1a],
GZB [auth 2A],
HAA [auth 1A],
HAB [auth 1a],
HAC [auth 2A],
HBA [auth 1A],
HBB [auth 1a],
HBC [auth 2A],
HCA [auth 1A],
HCB [auth 1a],
HCC [auth 2A],
HD [auth 1A],
HDA [auth 1A],
HDB [auth 1a],
HDC [auth 2A],
HE [auth 1A],
HEA [auth 1A],
HEB [auth 1a],
HEC [auth 2A],
HF [auth 1A],
HFA [auth 1A],
HFB [auth 1a],
HFC [auth 2A],
HG [auth 1A],
HGA [auth 1A],
HGB [auth 1a],
HGC [auth 2A],
HH [auth 1A],
HHA [auth 1A],
HHB [auth 1a],
HHC [auth 2A],
HI [auth 1A],
HIA [auth 1A],
HIB [auth 1e],
HIC [auth 2A],
HJ [auth 1A],
HJA [auth 1A],
HJB [auth 2A],
HJC [auth 2A],
HK [auth 1A],
HKA [auth 1A],
HKB [auth 2A],
HKC [auth 2A],
HL [auth 1A],
HLA [auth 1A],
HLB [auth 2A],
HLC [auth 2A],
HM [auth 1A],
HMA [auth 1A],
HMB [auth 2A],
HMC [auth 2B],
HN [auth 1A],
HNA [auth 1A],
HNB [auth 2A],
HNC [auth 2F],
HO [auth 1A],
HOA [auth 1A],
HOB [auth 2A],
HOC [auth 2W],
HP [auth 1A],
HPA [auth 1A],
HPB [auth 2A],
HPC [auth 2a],
HQ [auth 1A],
HQA [auth 1A],
HQB [auth 2A],
HQC [auth 2a],
HR [auth 1A],
HRA [auth 1B],
HRB [auth 2A],
HRC [auth 2a],
HS [auth 1A],
HSA [auth 1D],
HSB [auth 2A],
HSC [auth 2a],
HT [auth 1A],
HTA [auth 1F],
HTB [auth 2A],
HTC [auth 2a],
HU [auth 1A],
HUA [auth 1Q],
HUB [auth 2A],
HUC [auth 2a],
HV [auth 1A],
HVA [auth 1V],
HVB [auth 2A],
HVC [auth 2a],
HW [auth 1A],
HWA [auth 13],
HWB [auth 2A],
HWC [auth 2a],
HX [auth 1A],
HXA [auth 1a],
HXB [auth 2A],
HY [auth 1A],
HYA [auth 1a],
HYB [auth 2A],
HZ [auth 1A],
HZA [auth 1a],
HZB [auth 2A],
IAA [auth 1A],
IAB [auth 1a],
IAC [auth 2A],
IBA [auth 1A],
IBB [auth 1a],
IBC [auth 2A],
ICA [auth 1A],
ICB [auth 1a],
ICC [auth 2A],
ID [auth 1A],
IDA [auth 1A],
IDB [auth 1a],
IDC [auth 2A],
IE [auth 1A],
IEA [auth 1A],
IEB [auth 1a],
IEC [auth 2A],
IF [auth 1A],
IFA [auth 1A],
IFB [auth 1a],
IFC [auth 2A],
IG [auth 1A],
IGA [auth 1A],
IGB [auth 1a],
IGC [auth 2A],
IH [auth 1A],
IHA [auth 1A],
IHB [auth 1a],
IHC [auth 2A],
II [auth 1A],
IIA [auth 1A],
IIB [auth 1f],
IIC [auth 2A],
IJ [auth 1A],
IJA [auth 1A],
IJB [auth 2A],
IJC [auth 2A],
IK [auth 1A],
IKA [auth 1A],
IKB [auth 2A],
IKC [auth 2A],
IL [auth 1A],
ILA [auth 1A],
ILB [auth 2A],
ILC [auth 2A],
IM [auth 1A],
IMA [auth 1A],
IMB [auth 2A],
IMC [auth 2B],
IN [auth 1A],
INA [auth 1A],
INB [auth 2A],
INC [auth 2F],
IO [auth 1A],
IOA [auth 1A],
IOB [auth 2A],
IP [auth 1A],
IPA [auth 1A],
IPB [auth 2A],
IPC [auth 2a],
IQ [auth 1A],
IQA [auth 1A],
IQB [auth 2A],
IQC [auth 2a],
IR [auth 1A],
IRA [auth 1B],
IRB [auth 2A],
IRC [auth 2a],
IS [auth 1A],
ISA [auth 1D],
ISB [auth 2A],
ISC [auth 2a],
IT [auth 1A],
ITA [auth 1F],
ITB [auth 2A],
ITC [auth 2a],
IU [auth 1A],
IUA [auth 1Q],
IUB [auth 2A],
IUC [auth 2a],
IV [auth 1A],
IVA [auth 1V],
IVB [auth 2A],
IVC [auth 2a],
IW [auth 1A],
IWB [auth 2A],
IX [auth 1A],
IXA [auth 1a],
IXB [auth 2A],
IY [auth 1A],
IYA [auth 1a],
IYB [auth 2A],
IZ [auth 1A],
IZA [auth 1a],
IZB [auth 2A],
JAA [auth 1A],
JAB [auth 1a],
JAC [auth 2A],
JBA [auth 1A],
JBB [auth 1a],
JBC [auth 2A],
JCA [auth 1A],
JCB [auth 1a],
JCC [auth 2A],
JD [auth 1A],
JDA [auth 1A],
JDB [auth 1a],
JDC [auth 2A],
JE [auth 1A],
JEA [auth 1A],
JEB [auth 1a],
JEC [auth 2A],
JF [auth 1A],
JFA [auth 1A],
JFB [auth 1a],
JFC [auth 2A],
JG [auth 1A],
JGA [auth 1A],
JGB [auth 1a],
JGC [auth 2A],
JH [auth 1A],
JHA [auth 1A],
JHB [auth 1a],
JHC [auth 2A],
JI [auth 1A],
JIA [auth 1A],
JIB [auth 1g],
JIC [auth 2A],
JJ [auth 1A],
JJA [auth 1A],
JJB [auth 2A],
JJC [auth 2A],
JK [auth 1A],
JKA [auth 1A],
JKB [auth 2A],
JKC [auth 2A],
JL [auth 1A],
JLA [auth 1A],
JLB [auth 2A],
JLC [auth 2A],
JM [auth 1A],
JMA [auth 1A],
JMB [auth 2A],
JMC [auth 2B],
JN [auth 1A],
JNA [auth 1A],
JNB [auth 2A],
JNC [auth 2F],
JO [auth 1A],
JOA [auth 1A],
JOB [auth 2A],
JOC [auth 20],
JP [auth 1A],
JPA [auth 1A],
JPB [auth 2A],
JPC [auth 2a],
JQ [auth 1A],
JQA [auth 1A],
JQB [auth 2A],
JQC [auth 2a],
JR [auth 1A],
JRA [auth 1B],
JRB [auth 2A],
JRC [auth 2a],
JS [auth 1A],
JSA [auth 1D],
JSB [auth 2A],
JSC [auth 2a],
JT [auth 1A],
JTA [auth 1F],
JTB [auth 2A],
JTC [auth 2a],
JU [auth 1A],
JUA [auth 1Q],
JUB [auth 2A],
JUC [auth 2a],
JV [auth 1A],
JVA [auth 1V],
JVB [auth 2A],
JVC [auth 2a],
JW [auth 1A],
JWA [auth 15],
JWB [auth 2A],
JWC [auth 2e],
JX [auth 1A],
JXA [auth 1a],
JXB [auth 2A],
JY [auth 1A],
JYA [auth 1a],
JYB [auth 2A],
JZ [auth 1A],
JZA [auth 1a],
JZB [auth 2A],
KAA [auth 1A],
KAB [auth 1a],
KAC [auth 2A],
KBA [auth 1A],
KBB [auth 1a],
KBC [auth 2A],
KCA [auth 1A],
KCB [auth 1a],
KCC [auth 2A],
KD [auth 1A],
KDA [auth 1A],
KDB [auth 1a],
KDC [auth 2A],
KE [auth 1A],
KEA [auth 1A],
KEB [auth 1a],
KEC [auth 2A],
KF [auth 1A],
KFA [auth 1A],
KFB [auth 1a],
KFC [auth 2A],
KG [auth 1A],
KGA [auth 1A],
KGB [auth 1a],
KGC [auth 2A],
KH [auth 1A],
KHA [auth 1A],
KHB [auth 1a],
KHC [auth 2A],
KI [auth 1A],
KIA [auth 1A],
KIB [auth 1g],
KIC [auth 2A],
KJ [auth 1A],
KJA [auth 1A],
KJB [auth 2A],
KJC [auth 2A],
KK [auth 1A],
KKA [auth 1A],
KKB [auth 2A],
KKC [auth 2A],
KL [auth 1A],
KLA [auth 1A],
KLB [auth 2A],
KLC [auth 2A],
KM [auth 1A],
KMA [auth 1A],
KMB [auth 2A],
KMC [auth 2B],
KN [auth 1A],
KNA [auth 1A],
KNB [auth 2A],
KNC [auth 2F],
KO [auth 1A],
KOA [auth 1A],
KOB [auth 2A],
KOC [auth 21],
KP [auth 1A],
KPA [auth 1A],
KPB [auth 2A],
KPC [auth 2a],
KQ [auth 1A],
KQA [auth 1A],
KQB [auth 2A],
KQC [auth 2a],
KR [auth 1A],
KRA [auth 1B],
KRB [auth 2A],
KRC [auth 2a],
KS [auth 1A],
KSA [auth 1D],
KSB [auth 2A],
KSC [auth 2a],
KT [auth 1A],
KTA [auth 1F],
KTB [auth 2A],
KTC [auth 2a],
KU [auth 1A],
KUA [auth 1Q],
KUB [auth 2A],
KUC [auth 2a],
KV [auth 1A],
KVA [auth 1V],
KVB [auth 2A],
KVC [auth 2a],
KW [auth 1A],
KWA [auth 15],
KWB [auth 2A],
KWC [auth 2f],
KX [auth 1A],
KXA [auth 1a],
KXB [auth 2A],
KY [auth 1A],
KYA [auth 1a],
KYB [auth 2A],
KZ [auth 1A],
KZA [auth 1a],
KZB [auth 2A],
LAA [auth 1A],
LAB [auth 1a],
LAC [auth 2A],
LBA [auth 1A],
LBB [auth 1a],
LBC [auth 2A],
LCA [auth 1A],
LCB [auth 1a],
LCC [auth 2A],
LD [auth 1A],
LDA [auth 1A],
LDB [auth 1a],
LDC [auth 2A],
LE [auth 1A],
LEA [auth 1A],
LEB [auth 1a],
LEC [auth 2A],
LF [auth 1A],
LFA [auth 1A],
LFB [auth 1a],
LFC [auth 2A],
LG [auth 1A],
LGA [auth 1A],
LGB [auth 1a],
LGC [auth 2A],
LH [auth 1A],
LHA [auth 1A],
LHB [auth 1a],
LHC [auth 2A],
LI [auth 1A],
LIA [auth 1A],
LIB [auth 1h],
LIC [auth 2A],
LJ [auth 1A],
LJA [auth 1A],
LJB [auth 2A],
LJC [auth 2A],
LK [auth 1A],
LKA [auth 1A],
LKB [auth 2A],
LKC [auth 2A],
LL [auth 1A],
LLA [auth 1A],
LLB [auth 2A],
LLC [auth 2A],
LM [auth 1A],
LMA [auth 1A],
LMB [auth 2A],
LMC [auth 2B],
LN [auth 1A],
LNA [auth 1A],
LNB [auth 2A],
LNC [auth 2G],
LO [auth 1A],
LOA [auth 1A],
LOB [auth 2A],
LOC [auth 23],
LP [auth 1A],
LPA [auth 1A],
LPB [auth 2A],
LPC [auth 2a],
LQ [auth 1A],
LQA [auth 1A],
LQB [auth 2A],
LQC [auth 2a],
LR [auth 1A],
LRA [auth 1B],
LRB [auth 2A],
LRC [auth 2a],
LS [auth 1A],
LSA [auth 1D],
LSB [auth 2A],
LSC [auth 2a],
LT [auth 1A],
LTA [auth 1F],
LTB [auth 2A],
LTC [auth 2a],
LU [auth 1A],
LUA [auth 1Q],
LUB [auth 2A],
LUC [auth 2a],
LV [auth 1A],
LVA [auth 1V],
LVB [auth 2A],
LVC [auth 2a],
LW [auth 1A],
LWA [auth 15],
LWB [auth 2A],
LWC [auth 2h],
LX [auth 1A],
LXA [auth 1a],
LXB [auth 2A],
LY [auth 1A],
LYA [auth 1a],
LYB [auth 2A],
LZ [auth 1A],
LZA [auth 1a],
LZB [auth 2A],
MAA [auth 1A],
MAB [auth 1a],
MAC [auth 2A],
MBA [auth 1A],
MBB [auth 1a],
MBC [auth 2A],
MCA [auth 1A],
MCB [auth 1a],
MCC [auth 2A],
MD [auth 1A],
MDA [auth 1A],
MDB [auth 1a],
MDC [auth 2A],
ME [auth 1A],
MEA [auth 1A],
MEB [auth 1a],
MEC [auth 2A],
MF [auth 1A],
MFA [auth 1A],
MFB [auth 1a],
MFC [auth 2A],
MG [auth 1A],
MGA [auth 1A],
MGB [auth 1a],
MGC [auth 2A],
MH [auth 1A],
MHA [auth 1A],
MHB [auth 1a],
MHC [auth 2A],
MI [auth 1A],
MIA [auth 1A],
MIB [auth 1i],
MIC [auth 2A],
MJ [auth 1A],
MJA [auth 1A],
MJB [auth 2A],
MJC [auth 2A],
MK [auth 1A],
MKA [auth 1A],
MKB [auth 2A],
MKC [auth 2A],
ML [auth 1A],
MLA [auth 1A],
MLB [auth 2A],
MLC [auth 2A],
MM [auth 1A],
MMA [auth 1A],
MMB [auth 2A],
MMC [auth 2B],
MN [auth 1A],
MNA [auth 1A],
MNB [auth 2A],
MNC [auth 2G],
MO [auth 1A],
MOA [auth 1A],
MOB [auth 2A],
MOC [auth 23],
MP [auth 1A],
MPA [auth 1A],
MPB [auth 2A],
MPC [auth 2a],
MQ [auth 1A],
MQA [auth 1A],
MQB [auth 2A],
MQC [auth 2a],
MR [auth 1A],
MRA [auth 1B],
MRB [auth 2A],
MRC [auth 2a],
MS [auth 1A],
MSA [auth 1D],
MSB [auth 2A],
MSC [auth 2a],
MT [auth 1A],
MTA [auth 1F],
MTB [auth 2A],
MTC [auth 2a],
MU [auth 1A],
MUA [auth 1R],
MUB [auth 2A],
MUC [auth 2a],
MV [auth 1A],
MVA [auth 1V],
MVB [auth 2A],
MVC [auth 2a],
MW [auth 1A],
MWA [auth 15],
MWB [auth 2A],
MWC [auth 2j],
MX [auth 1A],
MXA [auth 1a],
MXB [auth 2A],
MY [auth 1A],
MYA [auth 1a],
MYB [auth 2A],
MZ [auth 1A],
MZA [auth 1a],
MZB [auth 2A],
NAA [auth 1A],
NAB [auth 1a],
NAC [auth 2A],
NBA [auth 1A],
NBB [auth 1a],
NBC [auth 2A],
NCA [auth 1A],
NCB [auth 1a],
NCC [auth 2A],
ND [auth 1A],
NDA [auth 1A],
NDB [auth 1a],
NDC [auth 2A],
NE [auth 1A],
NEA [auth 1A],
NEB [auth 1a],
NEC [auth 2A],
NF [auth 1A],
NFA [auth 1A],
NFB [auth 1a],
NFC [auth 2A],
NG [auth 1A],
NGA [auth 1A],
NGB [auth 1a],
NGC [auth 2A],
NH [auth 1A],
NHA [auth 1A],
NHB [auth 1a],
NHC [auth 2A],
NI [auth 1A],
NIA [auth 1A],
NIB [auth 1k],
NIC [auth 2A],
NJ [auth 1A],
NJA [auth 1A],
NJB [auth 2A],
NJC [auth 2A],
NK [auth 1A],
NKA [auth 1A],
NKB [auth 2A],
NKC [auth 2A],
NL [auth 1A],
NLA [auth 1A],
NLB [auth 2A],
NLC [auth 2A],
NM [auth 1A],
NMA [auth 1A],
NMB [auth 2A],
NMC [auth 2B],
NN [auth 1A],
NNA [auth 1A],
NNB [auth 2A],
NNC [auth 2G],
NO [auth 1A],
NOA [auth 1A],
NOB [auth 2A],
NP [auth 1A],
NPA [auth 1A],
NPB [auth 2A],
NPC [auth 2a],
NQ [auth 1A],
NQA [auth 1A],
NQB [auth 2A],
NQC [auth 2a],
NR [auth 1A],
NRA [auth 1B],
NRB [auth 2A],
NRC [auth 2a],
NS [auth 1A],
NSA [auth 1D],
NSB [auth 2A],
NSC [auth 2a],
NT [auth 1A],
NTA [auth 1F],
NTB [auth 2A],
NTC [auth 2a],
NU [auth 1A],
NUA [auth 1R],
NUB [auth 2A],
NUC [auth 2a],
NV [auth 1A],
NVA [auth 1W],
NVB [auth 2A],
NVC [auth 2a],
NW [auth 1A],
NWA [auth 15],
NWB [auth 2A],
NWC [auth 2k],
NX [auth 1A],
NXA [auth 1a],
NXB [auth 2A],
NY [auth 1A],
NYA [auth 1a],
NYB [auth 2A],
NZ [auth 1A],
NZA [auth 1a],
NZB [auth 2A],
OAA [auth 1A],
OAB [auth 1a],
OAC [auth 2A],
OBA [auth 1A],
OBB [auth 1a],
OBC [auth 2A],
OCA [auth 1A],
OCB [auth 1a],
OCC [auth 2A],
OD [auth 1A],
ODA [auth 1A],
ODB [auth 1a],
ODC [auth 2A],
OE [auth 1A],
OEA [auth 1A],
OEB [auth 1a],
OEC [auth 2A],
OF [auth 1A],
OFA [auth 1A],
OFB [auth 1a],
OFC [auth 2A],
OG [auth 1A],
OGA [auth 1A],
OGB [auth 1a],
OGC [auth 2A],
OH [auth 1A],
OHA [auth 1A],
OHB [auth 1a],
OHC [auth 2A],
OI [auth 1A],
OIA [auth 1A],
OIB [auth 1l],
OIC [auth 2A],
OJ [auth 1A],
OJA [auth 1A],
OJB [auth 2A],
OJC [auth 2A],
OK [auth 1A],
OKA [auth 1A],
OKB [auth 2A],
OKC [auth 2A],
OL [auth 1A],
OLA [auth 1A],
OLB [auth 2A],
OLC [auth 2A],
OM [auth 1A],
OMA [auth 1A],
OMB [auth 2A],
OMC [auth 2D],
ON [auth 1A],
ONA [auth 1A],
ONB [auth 2A],
ONC [auth 2I],
OO [auth 1A],
OOA [auth 1A],
OOB [auth 2A],
OOC [auth 25],
OP [auth 1A],
OPA [auth 1A],
OPB [auth 2A],
OPC [auth 2a],
OQ [auth 1A],
OQA [auth 1A],
OQB [auth 2A],
OQC [auth 2a],
OR [auth 1A],
ORA [auth 1B],
ORB [auth 2A],
ORC [auth 2a],
OS [auth 1A],
OSA [auth 1E],
OSB [auth 2A],
OSC [auth 2a],
OT [auth 1A],
OTA [auth 1F],
OTB [auth 2A],
OTC [auth 2a],
OU [auth 1A],
OUA [auth 1R],
OUB [auth 2A],
OUC [auth 2a],
OV [auth 1A],
OVA [auth 1W],
OVB [auth 2A],
OVC [auth 2a],
OW [auth 1A],
OWA [auth 15],
OWB [auth 2A],
OWC [auth 2n],
OX [auth 1A],
OXA [auth 1a],
OXB [auth 2A],
OY [auth 1A],
OYA [auth 1a],
OYB [auth 2A],
OZ [auth 1A],
OZA [auth 1a],
OZB [auth 2A],
PAA [auth 1A],
PAB [auth 1a],
PAC [auth 2A],
PBA [auth 1A],
PBB [auth 1a],
PBC [auth 2A],
PCA [auth 1A],
PCB [auth 1a],
PCC [auth 2A],
PD [auth 1A],
PDA [auth 1A],
PDB [auth 1a],
PDC [auth 2A],
PE [auth 1A],
PEA [auth 1A],
PEB [auth 1a],
PEC [auth 2A],
PF [auth 1A],
PFA [auth 1A],
PFB [auth 1a],
PFC [auth 2A],
PG [auth 1A],
PGA [auth 1A],
PGB [auth 1a],
PGC [auth 2A],
PH [auth 1A],
PHA [auth 1A],
PHB [auth 1a],
PHC [auth 2A],
PI [auth 1A],
PIA [auth 1A],
PIB [auth 1l],
PIC [auth 2A],
PJ [auth 1A],
PJA [auth 1A],
PJB [auth 2A],
PJC [auth 2A],
PK [auth 1A],
PKA [auth 1A],
PKB [auth 2A],
PKC [auth 2A],
PL [auth 1A],
PLA [auth 1A],
PLB [auth 2A],
PLC [auth 2A],
PM [auth 1A],
PMA [auth 1A],
PMB [auth 2A],
PMC [auth 2D],
PN [auth 1A],
PNA [auth 1A],
PNB [auth 2A],
PNC [auth 2N],
PO [auth 1A],
POA [auth 1A],
POB [auth 2A],
POC [auth 25],
PP [auth 1A],
PPA [auth 1A],
PPB [auth 2A],
PPC [auth 2a],
PQ [auth 1A],
PQA [auth 1A],
PQB [auth 2A],
PQC [auth 2a],
PR [auth 1A],
PRA [auth 1B],
PRB [auth 2A],
PRC [auth 2a],
PS [auth 1A],
PSA [auth 1E],
PSB [auth 2A],
PSC [auth 2a],
PT [auth 1A],
PTA [auth 1F],
PTB [auth 2A],
PTC [auth 2a],
PU [auth 1A],
PUA [auth 1R],
PUB [auth 2A],
PUC [auth 2a],
PV [auth 1A],
PVA [auth 1X],
PVB [auth 2A],
PVC [auth 2a],
PW [auth 1A],
PWA [auth 15],
PWB [auth 2A],
PX [auth 1A],
PXA [auth 1a],
PXB [auth 2A],
PY [auth 1A],
PYA [auth 1a],
PYB [auth 2A],
PZ [auth 1A],
PZA [auth 1a],
PZB [auth 2A],
QAA [auth 1A],
QAB [auth 1a],
QAC [auth 2A],
QBA [auth 1A],
QBB [auth 1a],
QBC [auth 2A],
QCA [auth 1A],
QCB [auth 1a],
QCC [auth 2A],
QD [auth 1A],
QDA [auth 1A],
QDB [auth 1a],
QDC [auth 2A],
QE [auth 1A],
QEA [auth 1A],
QEB [auth 1a],
QEC [auth 2A],
QF [auth 1A],
QFA [auth 1A],
QFB [auth 1a],
QFC [auth 2A],
QG [auth 1A],
QGA [auth 1A],
QGB [auth 1a],
QGC [auth 2A],
QH [auth 1A],
QHA [auth 1A],
QHB [auth 1a],
QHC [auth 2A],
QI [auth 1A],
QIA [auth 1A],
QIB [auth 1m],
QIC [auth 2A],
QJ [auth 1A],
QJA [auth 1A],
QJB [auth 2A],
QJC [auth 2A],
QK [auth 1A],
QKA [auth 1A],
QKB [auth 2A],
QKC [auth 2A],
QL [auth 1A],
QLA [auth 1A],
QLB [auth 2A],
QLC [auth 2A],
QM [auth 1A],
QMA [auth 1A],
QMB [auth 2A],
QMC [auth 2D],
QN [auth 1A],
QNA [auth 1A],
QNB [auth 2A],
QNC [auth 2O],
QO [auth 1A],
QOA [auth 1A],
QOB [auth 2A],
QOC [auth 25],
QP [auth 1A],
QPA [auth 1A],
QPB [auth 2A],
QPC [auth 2a],
QQ [auth 1A],
QQA [auth 1B],
QQB [auth 2A],
QQC [auth 2a],
QR [auth 1A],
QRA [auth 1B],
QRB [auth 2A],
QRC [auth 2a],
QS [auth 1A],
QSA [auth 1E],
QSB [auth 2A],
QSC [auth 2a],
QT [auth 1A],
QTA [auth 1F],
QTB [auth 2A],
QTC [auth 2a],
QU [auth 1A],
QUA [auth 1R],
QUB [auth 2A],
QUC [auth 2a],
QV [auth 1A],
QVA [auth 1Y],
QVB [auth 2A],
QVC [auth 2a],
QW [auth 1A],
QWA [auth 15],
QWB [auth 2A],
QWC [auth 2p],
QX [auth 1A],
QXA [auth 1a],
QXB [auth 2A],
QY [auth 1A],
QYA [auth 1a],
QYB [auth 2A],
QZ [auth 1A],
QZA [auth 1a],
QZB [auth 2A],
RAA [auth 1A],
RAB [auth 1a],
RAC [auth 2A],
RBA [auth 1A],
RBB [auth 1a],
RBC [auth 2A],
RCA [auth 1A],
RCB [auth 1a],
RCC [auth 2A],
RD [auth 1A],
RDA [auth 1A],
RDB [auth 1a],
RDC [auth 2A],
RE [auth 1A],
REA [auth 1A],
REB [auth 1a],
REC [auth 2A],
RF [auth 1A],
RFA [auth 1A],
RFB [auth 1a],
RFC [auth 2A],
RG [auth 1A],
RGA [auth 1A],
RGB [auth 1a],
RGC [auth 2A],
RH [auth 1A],
RHA [auth 1A],
RHB [auth 1a],
RHC [auth 2A],
RI [auth 1A],
RIA [auth 1A],
RIB [auth 1m],
RIC [auth 2A],
RJ [auth 1A],
RJA [auth 1A],
RJB [auth 2A],
RJC [auth 2A],
RK [auth 1A],
RKA [auth 1A],
RKB [auth 2A],
RKC [auth 2A],
RL [auth 1A],
RLA [auth 1A],
RLB [auth 2A],
RLC [auth 2A],
RM [auth 1A],
RMA [auth 1A],
RMB [auth 2A],
RMC [auth 2D],
RN [auth 1A],
RNA [auth 1A],
RNB [auth 2A],
RNC [auth 2P],
RO [auth 1A],
ROA [auth 1A],
ROB [auth 2A],
RP [auth 1A],
RPA [auth 1A],
RPB [auth 2A],
RPC [auth 2a],
RQ [auth 1A],
RQA [auth 1B],
RQB [auth 2A],
RQC [auth 2a],
RR [auth 1A],
RRA [auth 1B],
RRB [auth 2A],
RRC [auth 2a],
RS [auth 1A],
RSA [auth 1E],
RSB [auth 2A],
RSC [auth 2a],
RT [auth 1A],
RTA [auth 1G],
RTB [auth 2A],
RTC [auth 2a],
RU [auth 1A],
RUA [auth 1S],
RUB [auth 2A],
RUC [auth 2a],
RV [auth 1A],
RVB [auth 2A],
RVC [auth 2a],
RW [auth 1A],
RWB [auth 2A],
RWC [auth 2r],
RX [auth 1A],
RXA [auth 1a],
RXB [auth 2A],
RY [auth 1A],
RYA [auth 1a],
RYB [auth 2A],
RZ [auth 1A],
RZA [auth 1a],
RZB [auth 2A],
SAA [auth 1A],
SAB [auth 1a],
SAC [auth 2A],
SBA [auth 1A],
SBB [auth 1a],
SBC [auth 2A],
SCA [auth 1A],
SCB [auth 1a],
SCC [auth 2A],
SD [auth 1A],
SDA [auth 1A],
SDB [auth 1a],
SDC [auth 2A],
SE [auth 1A],
SEA [auth 1A],
SEB [auth 1a],
SEC [auth 2A],
SF [auth 1A],
SFA [auth 1A],
SFB [auth 1a],
SFC [auth 2A],
SG [auth 1A],
SGA [auth 1A],
SGB [auth 1a],
SGC [auth 2A],
SH [auth 1A],
SHA [auth 1A],
SHB [auth 1a],
SHC [auth 2A],
SI [auth 1A],
SIA [auth 1A],
SIB [auth 1n],
SIC [auth 2A],
SJ [auth 1A],
SJA [auth 1A],
SJB [auth 2A],
SJC [auth 2A],
SK [auth 1A],
SKA [auth 1A],
SKB [auth 2A],
SKC [auth 2A],
SL [auth 1A],
SLA [auth 1A],
SLB [auth 2A],
SLC [auth 2A],
SM [auth 1A],
SMA [auth 1A],
SMB [auth 2A],
SMC [auth 2D],
SN [auth 1A],
SNA [auth 1A],
SNB [auth 2A],
SNC [auth 2Q],
SO [auth 1A],
SOA [auth 1A],
SOB [auth 2A],
SP [auth 1A],
SPA [auth 1A],
SPB [auth 2A],
SPC [auth 2a],
SQ [auth 1A],
SQA [auth 1B],
SQB [auth 2A],
SQC [auth 2a],
SR [auth 1A],
SRA [auth 1B],
SRB [auth 2A],
SRC [auth 2a],
SS [auth 1A],
SSA [auth 1E],
SSB [auth 2A],
SSC [auth 2a],
ST [auth 1A],
STA [auth 1G],
STB [auth 2A],
STC [auth 2a],
SU [auth 1A],
SUA [auth 1T],
SUB [auth 2A],
SUC [auth 2a],
SV [auth 1A],
SVA [auth 1Z],
SVB [auth 2A],
SVC [auth 2a],
SW [auth 1A],
SWB [auth 2A],
SWC [auth 2t],
SX [auth 1A],
SXA [auth 1a],
SXB [auth 2A],
SY [auth 1A],
SYA [auth 1a],
SYB [auth 2A],
SZ [auth 1A],
SZA [auth 1a],
SZB [auth 2A],
TAA [auth 1A],
TAB [auth 1a],
TAC [auth 2A],
TBA [auth 1A],
TBB [auth 1a],
TBC [auth 2A],
TCA [auth 1A],
TCB [auth 1a],
TCC [auth 2A],
TD [auth 1A],
TDA [auth 1A],
TDB [auth 1a],
TDC [auth 2A],
TE [auth 1A],
TEA [auth 1A],
TEB [auth 1a],
TEC [auth 2A],
TF [auth 1A],
TFA [auth 1A],
TFB [auth 1a],
TFC [auth 2A],
TG [auth 1A],
TGA [auth 1A],
TGB [auth 1a],
TGC [auth 2A],
TH [auth 1A],
THA [auth 1A],
THB [auth 1a],
THC [auth 2A],
TI [auth 1A],
TIA [auth 1A],
TIC [auth 2A],
TJ [auth 1A],
TJA [auth 1A],
TJB [auth 2A],
TJC [auth 2A],
TK [auth 1A],
TKA [auth 1A],
TKB [auth 2A],
TKC [auth 2A],
TL [auth 1A],
TLA [auth 1A],
TLB [auth 2A],
TM [auth 1A],
TMA [auth 1A],
TMB [auth 2A],
TMC [auth 2D],
TN [auth 1A],
TNA [auth 1A],
TNB [auth 2A],
TNC [auth 2Q],
TO [auth 1A],
TOA [auth 1A],
TOB [auth 2A],
TOC [auth 27],
TP [auth 1A],
TPA [auth 1A],
TPB [auth 2A],
TPC [auth 2a],
TQ [auth 1A],
TQA [auth 1B],
TQB [auth 2A],
TQC [auth 2a],
TR [auth 1A],
TRA [auth 1B],
TRB [auth 2A],
TRC [auth 2a],
TS [auth 1A],
TSA [auth 1E],
TSB [auth 2A],
TSC [auth 2a],
TT [auth 1A],
TTA [auth 1G],
TTB [auth 2A],
TTC [auth 2a],
TU [auth 1A],
TUA [auth 1T],
TUB [auth 2A],
TUC [auth 2a],
TV [auth 1A],
TVA [auth 10],
TVB [auth 2A],
TVC [auth 2a],
TW [auth 1A],
TWA [auth 17],
TWB [auth 2A],
TWC [auth 2y],
TX [auth 1A],
TXA [auth 1a],
TXB [auth 2A],
TY [auth 1A],
TYA [auth 1a],
TYB [auth 2A],
TZ [auth 1A],
TZA [auth 1a],
TZB [auth 2A],
UAA [auth 1A],
UAB [auth 1a],
UAC [auth 2A],
UBA [auth 1A],
UBB [auth 1a],
UBC [auth 2A],
UCA [auth 1A],
UCB [auth 1a],
UCC [auth 2A],
UD [auth 1A],
UDA [auth 1A],
UDB [auth 1a],
UDC [auth 2A],
UE [auth 1A],
UEA [auth 1A],
UEB [auth 1a],
UEC [auth 2A],
UF [auth 1A],
UFA [auth 1A],
UFB [auth 1a],
UFC [auth 2A],
UG [auth 1A],
UGA [auth 1A],
UGB [auth 1a],
UGC [auth 2A],
UH [auth 1A],
UHA [auth 1A],
UHB [auth 1a],
UHC [auth 2A],
UI [auth 1A],
UIA [auth 1A],
UIB [auth 1o],
UIC [auth 2A],
UJ [auth 1A],
UJA [auth 1A],
UJB [auth 2A],
UJC [auth 2A],
UK [auth 1A],
UKA [auth 1A],
UKB [auth 2A],
UKC [auth 2A],
UL [auth 1A],
ULA [auth 1A],
ULB [auth 2A],
ULC [auth 2B],
UM [auth 1A],
UMA [auth 1A],
UMB [auth 2A],
UMC [auth 2D],
UN [auth 1A],
UNA [auth 1A],
UNB [auth 2A],
UNC [auth 2Q],
UO [auth 1A],
UOA [auth 1A],
UOB [auth 2A],
UOC [auth 28],
UP [auth 1A],
UPA [auth 1A],
UPB [auth 2A],
UPC [auth 2a],
UQ [auth 1A],
UQA [auth 1B],
UQB [auth 2A],
UQC [auth 2a],
UR [auth 1A],
URA [auth 1B],
URB [auth 2A],
URC [auth 2a],
US [auth 1A],
USA [auth 1E],
USB [auth 2A],
USC [auth 2a],
UT [auth 1A],
UTA [auth 1G],
UTB [auth 2A],
UTC [auth 2a],
UU [auth 1A],
UUA [auth 1T],
UUB [auth 2A],
UUC [auth 2a],
UV [auth 1A],
UVA [auth 10],
UVB [auth 2A],
UVC [auth 2a],
UW [auth 1A],
UWA [auth 17],
UWB [auth 2A],
UX [auth 1A],
UXA [auth 1a],
UXB [auth 2A],
UY [auth 1A],
UYA [auth 1a],
UYB [auth 2A],
UZ [auth 1A],
UZA [auth 1a],
UZB [auth 2A],
VAA [auth 1A],
VAB [auth 1a],
VAC [auth 2A],
VBA [auth 1A],
VBB [auth 1a],
VBC [auth 2A],
VCA [auth 1A],
VCB [auth 1a],
VCC [auth 2A],
VD [auth 1A],
VDA [auth 1A],
VDB [auth 1a],
VDC [auth 2A],
VE [auth 1A],
VEA [auth 1A],
VEB [auth 1a],
VEC [auth 2A],
VF [auth 1A],
VFA [auth 1A],
VFB [auth 1a],
VFC [auth 2A],
VG [auth 1A],
VGA [auth 1A],
VGB [auth 1a],
VGC [auth 2A],
VH [auth 1A],
VHA [auth 1A],
VHB [auth 1b],
VHC [auth 2A],
VI [auth 1A],
VIA [auth 1A],
VIB [auth 1o],
VIC [auth 2A],
VJ [auth 1A],
VJA [auth 1A],
VJB [auth 2A],
VJC [auth 2A],
VK [auth 1A],
VKA [auth 1A],
VKB [auth 2A],
VKC [auth 2A],
VL [auth 1A],
VLA [auth 1A],
VLB [auth 2A],
VLC [auth 2B],
VM [auth 1A],
VMA [auth 1A],
VMB [auth 2A],
VMC [auth 2D],
VN [auth 1A],
VNA [auth 1A],
VNB [auth 2A],
VNC [auth 2Q],
VO [auth 1A],
VOA [auth 1A],
VOB [auth 2A],
VOC [auth 28],
VP [auth 1A],
VPA [auth 1A],
VPB [auth 2A],
VPC [auth 2a],
VQ [auth 1A],
VQA [auth 1B],
VQB [auth 2A],
VQC [auth 2a],
VR [auth 1A],
VRB [auth 2A],
VRC [auth 2a],
VS [auth 1A],
VSA [auth 1E],
VSB [auth 2A],
VSC [auth 2a],
VT [auth 1A],
VTA [auth 1H],
VTB [auth 2A],
VTC [auth 2a],
VU [auth 1A],
VUA [auth 1T],
VUB [auth 2A],
VUC [auth 2a],
VV [auth 1A],
VVA [auth 10],
VVB [auth 2A],
VVC [auth 2a],
VW [auth 1A],
VWA [auth 17],
VWB [auth 2A],
VX [auth 1A],
VXA [auth 1a],
VXB [auth 2A],
VY [auth 1A],
VYA [auth 1a],
VYB [auth 2A],
VZ [auth 1A],
VZA [auth 1a],
VZB [auth 2A],
WAA [auth 1A],
WAB [auth 1a],
WAC [auth 2A],
WBA [auth 1A],
WBB [auth 1a],
WBC [auth 2A],
WCA [auth 1A],
WCB [auth 1a],
WCC [auth 2A],
WD [auth 1A],
WDA [auth 1A],
WDB [auth 1a],
WDC [auth 2A],
WE [auth 1A],
WEA [auth 1A],
WEB [auth 1a],
WEC [auth 2A],
WF [auth 1A],
WFA [auth 1A],
WFB [auth 1a],
WFC [auth 2A],
WG [auth 1A],
WGA [auth 1A],
WGB [auth 1a],
WGC [auth 2A],
WH [auth 1A],
WHA [auth 1A],
WHB [auth 1d],
WHC [auth 2A],
WI [auth 1A],
WIA [auth 1A],
WIB [auth 1r],
WIC [auth 2A],
WJ [auth 1A],
WJA [auth 1A],
WJB [auth 2A],
WJC [auth 2A],
WK [auth 1A],
WKA [auth 1A],
WKB [auth 2A],
WKC [auth 2A],
WL [auth 1A],
WLA [auth 1A],
WLB [auth 2A],
WLC [auth 2B],
WM [auth 1A],
WMA [auth 1A],
WMB [auth 2A],
WMC [auth 2D],
WN [auth 1A],
WNA [auth 1A],
WNB [auth 2A],
WNC [auth 2R],
WO [auth 1A],
WOA [auth 1A],
WOB [auth 2A],
WP [auth 1A],
WPA [auth 1A],
WPB [auth 2A],
WPC [auth 2a],
WQ [auth 1A],
WQA [auth 1B],
WQB [auth 2A],
WQC [auth 2a],
WR [auth 1A],
WRA [auth 1D],
WRB [auth 2A],
WRC [auth 2a],
WS [auth 1A],
WSA [auth 1E],
WSB [auth 2A],
WSC [auth 2a],
WT [auth 1A],
WTA [auth 1H],
WTB [auth 2A],
WTC [auth 2a],
WU [auth 1A],
WUA [auth 1T],
WUB [auth 2A],
WUC [auth 2a],
WV [auth 1A],
WVA [auth 10],
WVB [auth 2A],
WVC [auth 2a],
WW [auth 1A],
WWA [auth 17],
WWB [auth 2A],
WX [auth 1A],
WXA [auth 1a],
WXB [auth 2A],
WY [auth 1A],
WYA [auth 1a],
WYB [auth 2A],
WZ [auth 1A],
WZA [auth 1a],
WZB [auth 2A],
XAA [auth 1A],
XAB [auth 1a],
XAC [auth 2A],
XBA [auth 1A],
XBB [auth 1a],
XBC [auth 2A],
XCA [auth 1A],
XCB [auth 1a],
XCC [auth 2A],
XD [auth 1A],
XDA [auth 1A],
XDB [auth 1a],
XDC [auth 2A],
XE [auth 1A],
XEA [auth 1A],
XEB [auth 1a],
XEC [auth 2A],
XF [auth 1A],
XFA [auth 1A],
XFB [auth 1a],
XFC [auth 2A],
XG [auth 1A],
XGA [auth 1A],
XGB [auth 1a],
XGC [auth 2A],
XH [auth 1A],
XHA [auth 1A],
XHB [auth 1d],
XHC [auth 2A],
XI [auth 1A],
XIA [auth 1A],
XIB [auth 1t],
XIC [auth 2A],
XJ [auth 1A],
XJA [auth 1A],
XJB [auth 2A],
XJC [auth 2A],
XK [auth 1A],
XKA [auth 1A],
XKB [auth 2A],
XKC [auth 2A],
XL [auth 1A],
XLA [auth 1A],
XLB [auth 2A],
XLC [auth 2B],
XM [auth 1A],
XMA [auth 1A],
XMB [auth 2A],
XMC [auth 2D],
XN [auth 1A],
XNA [auth 1A],
XNB [auth 2A],
XNC [auth 2R],
XO [auth 1A],
XOA [auth 1A],
XOB [auth 2A],
XOC [auth 2a],
XP [auth 1A],
XPA [auth 1A],
XPB [auth 2A],
XPC [auth 2a],
XQ [auth 1A],
XQA [auth 1B],
XQB [auth 2A],
XQC [auth 2a],
XR [auth 1A],
XRA [auth 1D],
XRB [auth 2A],
XRC [auth 2a],
XS [auth 1A],
XSA [auth 1F],
XSB [auth 2A],
XSC [auth 2a],
XT [auth 1A],
XTA [auth 1N],
XTB [auth 2A],
XTC [auth 2a],
XU [auth 1A],
XUB [auth 2A],
XUC [auth 2a],
XV [auth 1A],
XVA [auth 10],
XVB [auth 2A],
XVC [auth 2a],
XW [auth 1A],
XWA [auth 17],
XWB [auth 2A],
XX [auth 1A],
XXA [auth 1a],
XXB [auth 2A],
XY [auth 1A],
XYA [auth 1a],
XYB [auth 2A],
XZ [auth 1A],
XZA [auth 1a],
XZB [auth 2A],
YAA [auth 1A],
YAB [auth 1a],
YAC [auth 2A],
YBA [auth 1A],
YBB [auth 1a],
YBC [auth 2A],
YCA [auth 1A],
YCB [auth 1a],
YCC [auth 2A],
YD [auth 1A],
YDA [auth 1A],
YDB [auth 1a],
YDC [auth 2A],
YE [auth 1A],
YEA [auth 1A],
YEB [auth 1a],
YEC [auth 2A],
YF [auth 1A],
YFA [auth 1A],
YFB [auth 1a],
YFC [auth 2A],
YG [auth 1A],
YGA [auth 1A],
YGB [auth 1a],
YGC [auth 2A],
YH [auth 1A],
YHA [auth 1A],
YHB [auth 1d],
YHC [auth 2A],
YI [auth 1A],
YIA [auth 1A],
YIB [auth 1y],
YIC [auth 2A],
YJ [auth 1A],
YJA [auth 1A],
YJB [auth 2A],
YJC [auth 2A],
YK [auth 1A],
YKA [auth 1A],
YKB [auth 2A],
YKC [auth 2A],
YL [auth 1A],
YLA [auth 1A],
YLB [auth 2A],
YLC [auth 2B],
YM [auth 1A],
YMA [auth 1A],
YMB [auth 2A],
YMC [auth 2D],
YN [auth 1A],
YNA [auth 1A],
YNB [auth 2A],
YNC [auth 2T],
YO [auth 1A],
YOA [auth 1A],
YOB [auth 2A],
YOC [auth 2a],
YP [auth 1A],
YPA [auth 1A],
YPB [auth 2A],
YPC [auth 2a],
YQ [auth 1A],
YQA [auth 1B],
YQB [auth 2A],
YQC [auth 2a],
YR [auth 1A],
YRA [auth 1D],
YRB [auth 2A],
YRC [auth 2a],
YS [auth 1A],
YSA [auth 1F],
YSB [auth 2A],
YSC [auth 2a],
YT [auth 1A],
YTA [auth 1N],
YTB [auth 2A],
YTC [auth 2a],
YU [auth 1A],
YUA [auth 1U],
YUB [auth 2A],
YUC [auth 2a],
YV [auth 1A],
YVA [auth 10],
YVB [auth 2A],
YVC [auth 2a],
YW [auth 1A],
YWA [auth 17],
YWB [auth 2A],
YX [auth 1A],
YXA [auth 1a],
YXB [auth 2A],
YY [auth 1A],
YYA [auth 1a],
YYB [auth 2A],
YZ [auth 1A],
YZA [auth 1a],
YZB [auth 2A],
ZAA [auth 1A],
ZAB [auth 1a],
ZAC [auth 2A],
ZBA [auth 1A],
ZBB [auth 1a],
ZBC [auth 2A],
ZCA [auth 1A],
ZCB [auth 1a],
ZCC [auth 2A],
ZD [auth 1A],
ZDA [auth 1A],
ZDB [auth 1a],
ZDC [auth 2A],
ZE [auth 1A],
ZEA [auth 1A],
ZEB [auth 1a],
ZEC [auth 2A],
ZF [auth 1A],
ZFA [auth 1A],
ZFB [auth 1a],
ZFC [auth 2A],
ZG [auth 1A],
ZGA [auth 1A],
ZGB [auth 1a],
ZGC [auth 2A],
ZH [auth 1A],
ZHA [auth 1A],
ZHB [auth 1d],
ZHC [auth 2A],
ZI [auth 1A],
ZIA [auth 1A],
ZIB [auth 1y],
ZIC [auth 2A],
ZJ [auth 1A],
ZJA [auth 1A],
ZJB [auth 2A],
ZJC [auth 2A],
ZK [auth 1A],
ZKA [auth 1A],
ZKB [auth 2A],
ZKC [auth 2A],
ZL [auth 1A],
ZLA [auth 1A],
ZLB [auth 2A],
ZLC [auth 2B],
ZM [auth 1A],
ZMA [auth 1A],
ZMB [auth 2A],
ZMC [auth 2D],
ZN [auth 1A],
ZNA [auth 1A],
ZNB [auth 2A],
ZNC [auth 2T],
ZO [auth 1A],
ZOA [auth 1A],
ZOB [auth 2A],
ZOC [auth 2a],
ZP [auth 1A],
ZPA [auth 1A],
ZPB [auth 2A],
ZPC [auth 2a],
ZQ [auth 1A],
ZQA [auth 1B],
ZQB [auth 2A],
ZQC [auth 2a],
ZR [auth 1A],
ZRA [auth 1D],
ZRB [auth 2A],
ZRC [auth 2a],
ZS [auth 1A],
ZSA [auth 1F],
ZSB [auth 2A],
ZSC [auth 2a],
ZT [auth 1A],
ZTA [auth 1N],
ZTB [auth 2A],
ZTC [auth 2a],
ZU [auth 1A],
ZUA [auth 1U],
ZUB [auth 2A],
ZUC [auth 2a],
ZV [auth 1A],
ZVA [auth 10],
ZVB [auth 2A],
ZVC [auth 2a],
ZW [auth 1A],
ZWA [auth 18],
ZWB [auth 2A],
ZX [auth 1A],
ZXA [auth 1a],
ZXB [auth 2A],
ZY [auth 1A],
ZYA [auth 1a],
ZYB [auth 2A],
ZZ [auth 1A],
ZZA [auth 1a],
ZZB [auth 2A]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Modified Residues  1 Unique
IDChains TypeFormula2D DiagramParent
0TD
Query on 0TD		QA [auth 1l],
SC [auth 2l]		L-PEPTIDE LINKINGC5 H9 N O4 SASP
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.60 Å
  • R-Value Free: 0.252 
  • R-Value Work: 0.202 
  • R-Value Observed: 0.204 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 207.14α = 90
b = 444.01β = 90
c = 615.2γ = 90
Software Package:
Software NamePurpose
PHENIXrefinement
XDSdata reduction
XSCALEdata scaling
PHASERphasing
Cootmodel building
PDB_EXTRACTdata extraction

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


View more in-depth experimental data
Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesR01-GM132302
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesR35-GM151957
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesR35-GM127134
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)United StatesR01-AI162961
National Science Foundation (NSF, United States)United StatesMCB-2345351
Canadian Institutes of Health Research (CIHR)CanadaPJT190298
Other governmentUnited StatesUniversity of Illinois Startup Funds

Revision History  (Full details and data files)

  • Version 1.0: 2024-11-20
    Type: Initial release