Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyThiolase-like 8033429 3000122 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThiolase-like 8033428 3000122 SCOP2B (2022-06-29)
BSCOP2 FamilyThiolase-related 8021048 4000245 SCOP2 (2022-06-29)
BSCOP2 FamilyThiolase-related 8021049 4000245 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyThiolase-like 8033428 3000122 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyThiolase-like 8033429 3000122 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AThiolase_Ce1afwA2 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Thiolase_CECOD (1.6)
AThiolase_Ne1afwA1 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Thiolase_NECOD (1.6)
BThiolase_Ce1afwB2 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Thiolase_CECOD (1.6)
BThiolase_Ne1afwB1 A: a/b three-layered sandwichesX: Thiolase-like (From Topology)H: Thiolase-like (From Topology)T: Thiolase-likeF: Thiolase_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase Chain A, domain 1CATH (4.3.0)
B3.40.47.10 Alpha Beta 3-Layer(aba) Sandwich Peroxisomal Thiolase Chain A, domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF02803Thiolase, C-terminal domain (Thiolase_C)Thiolase, C-terminal domainThiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.Domain
A, B
PF00108Thiolase, N-terminal domain (Thiolase_N)Thiolase, N-terminal domainThiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
3-KETOACETYL-COA THIOLASE

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
acetyl-CoA C-acyltransferase  M-CSA #77

Thiolases form a ubiquitous family of enzymes found in both prokaryotes and eukaryotes. Thiolases catalyse the reversible two step cleavage of acyl-CoA into CoA and acetyl-CoA. There are two classes of thiolases, I and II. This entry represents the Class II thiolases. Class II only acts upon acetoacetyl-CoA and its main function is to synthesise this compound in a Claisen condensation reaction important in several biosynthetic pathways.

Defined by 4 residues: CYS:A-101 [auth A-125]HIS:A-351 [auth A-375]CYS:A-379 [auth A-403]GLY:A-381 [auth A-405]
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