Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1arza1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Dihydrodipicolinate reductase (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ad1arza2 Alpha and beta proteins (a+b) FwdE/GAPDH domain-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Dihydrodipicolinate reductase-like Dihydrodipicolinate reductase (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Bd1arzb1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Dihydrodipicolinate reductase (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Bd1arzb2 Alpha and beta proteins (a+b) FwdE/GAPDH domain-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Dihydrodipicolinate reductase-like Dihydrodipicolinate reductase (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Cd1arzc1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Dihydrodipicolinate reductase (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Cd1arzc2 Alpha and beta proteins (a+b) FwdE/GAPDH domain-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Dihydrodipicolinate reductase-like Dihydrodipicolinate reductase (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Dd1arzd1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Dihydrodipicolinate reductase (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Dd1arzd2 Alpha and beta proteins (a+b) FwdE/GAPDH domain-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Dihydrodipicolinate reductase-like Dihydrodipicolinate reductase (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyGAPDH-like 8000961 3000043 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyGAPDH-like 8000961 3000043 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyGAPDH-like 8000961 3000043 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyGAPDH-like 8000961 3000043 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADapB_Ce1arzA1 A: a+b two layersX: FwdE/GAPDH domain-likeH: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainF: DapB_CECOD (1.6)
ADapB_Ne1arzA2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: DapB_NECOD (1.6)
BDapB_Ce1arzB1 A: a+b two layersX: FwdE/GAPDH domain-likeH: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainF: DapB_CECOD (1.6)
BDapB_Ne1arzB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: DapB_NECOD (1.6)
CDapB_Ce1arzC1 A: a+b two layersX: FwdE/GAPDH domain-likeH: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainF: DapB_CECOD (1.6)
CDapB_Ne1arzC2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: DapB_NECOD (1.6)
DDapB_Ce1arzD1 A: a+b two layersX: FwdE/GAPDH domain-likeH: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainF: DapB_CECOD (1.6)
DDapB_Ne1arzD2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: DapB_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF05173Dihydrodipicolinate reductase, C-terminus (DapB_C)Dihydrodipicolinate reductase, C-terminusDihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate. This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for bo ...Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate. This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both protein and cell wall biosynthesis. The C-terminal domain of DapB has been proposed to be the substrate- binding domain.
Domain
A, B, C, D
PF01113Dihydrodipicolinate reductase, N-terminus (DapB_N)Dihydrodipicolinate reductase, N-terminusDihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate. This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for b ...Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate. This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both protein and cell wall biosynthesis. The N-terminal domain of DapB binds the dinucleotide NADPH.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
DIHYDRODIPICOLINATE REDUCTASE

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
dihydrodipicolinate reductase  M-CSA #402

Dihydrodipicolinate reductase catalyses the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. It can use both NADH and NADPH as a reductant, with NADH being twice as effective as NADPH

The enzyme is a component of the biosynthetic pathway that leads to diaminopimelate and lysine in bacteria and higher plants. Because these pathways are unique to microorganisms and plants, they may represent attractive targets for new antimicrobial or herbicidal compounds.

Defined by 2 residues: HIS:A-159LYS:A-163
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