Annotations: 1B6S

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1b6sa1	All beta proteins	Barrel-sandwich hybrid	Rudiment single hybrid motif	BC C-terminal domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1b6sa2	Alpha and beta proteins (a/b)	PreATP-grasp domain	PreATP-grasp domain	BC N-terminal domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1b6sa3	Alpha and beta proteins (a+b)	ATP-grasp	Glutathione synthetase ATP-binding domain-like	BC ATP-binding domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1b6sb1	All beta proteins	Barrel-sandwich hybrid	Rudiment single hybrid motif	BC C-terminal domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1b6sb2	Alpha and beta proteins (a/b)	PreATP-grasp domain	PreATP-grasp domain	BC N-terminal domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1b6sb3	Alpha and beta proteins (a+b)	ATP-grasp	Glutathione synthetase ATP-binding domain-like	BC ATP-binding domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1b6sc1	All beta proteins	Barrel-sandwich hybrid	Rudiment single hybrid motif	BC C-terminal domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1b6sc2	Alpha and beta proteins (a/b)	PreATP-grasp domain	PreATP-grasp domain	BC N-terminal domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1b6sc3	Alpha and beta proteins (a+b)	ATP-grasp	Glutathione synthetase ATP-binding domain-like	BC ATP-binding domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1b6sd1	All beta proteins	Barrel-sandwich hybrid	Rudiment single hybrid motif	BC C-terminal domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1b6sd2	Alpha and beta proteins (a/b)	PreATP-grasp domain	PreATP-grasp domain	BC N-terminal domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1b6sd3	Alpha and beta proteins (a+b)	ATP-grasp	Glutathione synthetase ATP-binding domain-like	BC ATP-binding domain-like	N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PreATP-grasp domain	8041114	3001680	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Rudiment single hybrid motif	8041112	3001910	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Glutathione synthetase ATP-binding domain-like	8041115	3000094	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PreATP-grasp domain	8041114	3001680	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Rudiment single hybrid motif	8041112	3001910	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Glutathione synthetase ATP-binding domain-like	8041115	3000094	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PreATP-grasp domain	8041114	3001680	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Rudiment single hybrid motif	8041112	3001910	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Glutathione synthetase ATP-binding domain-like	8041115	3000094	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Glutathione synthetase ATP-binding domain-like	8041115	3000094	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PreATP-grasp domain	8041114	3001680	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Rudiment single hybrid motif	8041112	3001910	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ATP-grasp	e1b6sA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: ATP-grasp	ECOD (1.6)
A	PRK06019_2	e1b6sA2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: PRK06019_2	ECOD (1.6)
A	2-Hacid_dh_C_2	e1b6sA3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: 2-Hacid_dh_C_2	ECOD (1.6)
B	ATP-grasp	e1b6sB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: ATP-grasp	ECOD (1.6)
B	PRK06019_2	e1b6sB2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: PRK06019_2	ECOD (1.6)
B	2-Hacid_dh_C_2	e1b6sB3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: 2-Hacid_dh_C_2	ECOD (1.6)
C	ATP-grasp	e1b6sC1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: ATP-grasp	ECOD (1.6)
C	PRK06019_2	e1b6sC2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: PRK06019_2	ECOD (1.6)
C	2-Hacid_dh_C_2	e1b6sC3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: 2-Hacid_dh_C_2	ECOD (1.6)
D	ATP-grasp	e1b6sD1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: ATP-grasp	ECOD (1.6)
D	PRK06019_2	e1b6sD2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: PRK06019_2	ECOD (1.6)
D	2-Hacid_dh_C_2	e1b6sD3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: 2-Hacid_dh_C_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.20	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	3.30.470.20	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
A	3.30.1490.20	Alpha Beta	2-Layer Sandwich	Dna Ligase	domain 1	CATH (4.3.0)
B	3.40.50.20	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.30.470.20	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
B	3.30.1490.20	Alpha Beta	2-Layer Sandwich	Dna Ligase	domain 1	CATH (4.3.0)
C	3.40.50.20	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.30.470.20	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
C	3.30.1490.20	Alpha Beta	2-Layer Sandwich	Dna Ligase	domain 1	CATH (4.3.0)
D	3.40.50.20	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	3.30.470.20	Alpha Beta	2-Layer Sandwich	D-amino Acid Aminotransferase	Chain A, domain 1	CATH (4.3.0)
D	3.30.1490.20	Alpha Beta	2-Layer Sandwich	Dna Ligase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF22660	Ribonucleotide synthetase preATP-grasp domain (RS_preATP-grasp-like)	Ribonucleotide synthetase preATP-grasp domain	This domain precedes the ATP-grasp domain in a number of ribonucleotide synthetases [1-5].	Domain
A, B, C, D	PF02222	ATP-grasp domain (ATP-grasp)	ATP-grasp domain	-	Family
A, B, C, D	PF17769	Phosphoribosylaminoimidazole carboxylase C-terminal domain (PurK_C)	Phosphoribosylaminoimidazole carboxylase C-terminal domain	This entry represents the C-terminal domain of the PurK enzyme.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	PROTEIN (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE)	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding 5-(carboxyamino)imidazole ribonucleotide synthase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity phosphoribosylaminoimidazole carboxylase activity carboxy-lyase activity lyase activity carbon-carbon lyase activity cation binding metal ion binding	ribose phosphate metabolic process IMP metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process ribose phosphate metabolic process IMP metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside monophosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process purine-containing compound metabolic process IMP biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process 'de novo' IMP biosynthetic process purine ribonucleotide metabolic process ribonucleoside monophosphate biosynthetic process purine nucleotide biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR011761	ATP-grasp fold	Domain
A, B, C, D	IPR054350	PurT/PurK-like, preATP-grasp domain	Domain
A, B, C, D	IPR013815	ATP-grasp fold, subdomain 1	Homologous Superfamily
A, B, C, D	IPR003135	ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type	Domain
A, B, C, D	IPR005875	Phosphoribosylaminoimidazole carboxylase, ATPase subunit	Domain
A, B, C, D	IPR016185	Pre-ATP-grasp domain superfamily	Homologous Superfamily
A, B, C, D	IPR011054	Rudiment single hybrid motif	Homologous Superfamily
A, B, C, D	IPR040686	Phosphoribosylaminoimidazole carboxylase, C-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.