Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNucleotide cyclase/DNA polymerase palm domain-like 8035568 3001272 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyNucleotide cyclase/DNA polymerase palm domain-like 8035576 3001272 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyRas-like P-loop GTPases 8056791 3002022 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyGalpha insert domain-like 8056792 3000669 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyRas-like P-loop GTPases 8056791 3002022 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AGuanylate_cyce1cjuA1 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: Guanylate_cycECOD (1.6)
BGuanylate_cyce1cjuB1 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: Guanylate_cycECOD (1.6)
CG-alphae1cjuC1 A: alpha arraysX: Transducin (alpha subunit), insertion domain (From Topology)H: Transducin (alpha subunit), insertion domain (From Topology)T: Transducin (alpha subunit), insertion domainF: G-alphaECOD (1.6)
CRase1cjuC2 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00211Adenylate and Guanylate cyclase catalytic domain (Guanylate_cyc)Adenylate and Guanylate cyclase catalytic domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
ADENYLATE CYCLASE, TYPE V
ADENYLATE CYCLASE, TYPE II
GUANINE NUCLEOTIDE-BINDING PROTEIN G(S)

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
A, B
adenylate cyclase  M-CSA #58

Adenylate cyclase converts adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP), a ubiquitous second messenger that regulates many functions. Many signalling pathways triggered by hormones and other biological processes converge on and regulate the integral membrane enzyme, including those of the heterotrimeric GTP-binding proteins. There are over 30 related proteins, including bacterial and fungal adenylyl cyclases as well as guanylyl cyclases.

Defined by 5 residues: ASP:A-33 [auth A-396]ILE:A-34 [auth A-397]ASP:A-77 [auth A-440]ARG:B-160 [auth B-1029]LYS:B-196 [auth B-1065]
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