Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1cv2a_ Alpha and beta proteins (a/b) alpha/beta-Hydrolases alpha/beta-Hydrolases Haloalkane dehalogenase Haloalkane dehalogenase (Sphingomonas paucimobilis ) [TaxId: 13689 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B Superfamilyalpha/beta-Hydrolases 8036400 3000102 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHydrolase_4_1e1cv2A1 A: a/b three-layered sandwichesX: alpha/beta-Hydrolases (From Topology)H: alpha/beta-Hydrolases (From Topology)T: alpha/beta-HydrolasesF: Hydrolase_4_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.1820 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Alpha/Beta hydrolase fold, catalytic domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00561alpha/beta hydrolase fold (Abhydrolase_1)alpha/beta hydrolase foldThis catalytic domain is found in a very wide range of enzymes.Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
haloalkane dehalogenase (subfamily 2)  M-CSA #467

The Haloalkane dehalogenase LinB, found in bacteria, catalyses the convertion of a broad range of natural and synthetic halogenated compounds (e.g., alkanes, alkenes, cycloalkanes, alcohols, epoxides, carboxylic acids, esters, ethers, amides, and nitriles) by replacing the halogen atom (chloro, bromo, or iodo) with a hydroxyl group. It is of special interest in its ability to degrade the toxic compound 1,2,3,4,5,6-hexachlorocyclohexane. Thus study of the enzyme is important in understanding how bacteria are able to degrade xenobiotics and how pollutants can be detoxified using microorganisms. The enzyme is part of the alpha-beta hydrolase family and shows sequence and structural homology with a wide variety of haloalkane dehalogenases with different specificities.

Defined by 5 residues: ASN:A-38ASP:A-108TRP:A-109GLU:A-132HIS:A-272
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