Annotations: 1D5R

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1d5ra1	All beta proteins	C2 domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	PLC-like (P variant)	Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ], human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1d5ra2	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	Dual specificity phosphatase-like	Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ], human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PLC-like (P variant)	8028334	4002218	SCOP2 (2022-06-29)
A	SCOP2 Family	Dual specificity phosphatase-like	8031976	4000437	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C2 domain (calcium/lipid-binding domain, calb)	8040713	3000965	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	(Phosphotyrosine protein) phosphatases II	8044354	3000304	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PTEN_C2	e1d5rA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: PTEN_C2	ECOD (1.6)
A	Y_phosphatase	e1d5rA2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: Y_phosphatase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)
A	2.60.40.1110	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF22785	Polymorphic toxin system, DSP-PTPase phosphatase (Tc-R-P)	Polymorphic toxin system, DSP-PTPase phosphatase	This domain occupies the toxin tip position in a subset of polymorphic toxin domains [1,2]. This domain is found at the extreme C-terminal of certain polymorphic toxin-related Tc-like toxins deployed by bacteria against eukaryotic host cells. This po ...	This domain occupies the toxin tip position in a subset of polymorphic toxin domains [1,2]. This domain is found at the extreme C-terminal of certain polymorphic toxin-related Tc-like toxins deployed by bacteria against eukaryotic host cells. This position is where the toxin module delivered into the target cells host resides [1].	Domain
A	PF10409	C2 domain of PTEN tumour-suppressor protein (PTEN_C2)	C2 domain of PTEN tumour-suppressor protein	This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. Th ...	This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (Pfam:PF00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PHOSPHOINOSITIDE PHOSPHATASE PTEN	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity inositol pentakisphosphate phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol phosphate phosphatase activity inositol tetrakisphosphate phosphatase activity inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity enzyme regulator activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity inositol pentakisphosphate phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol phosphate phosphatase activity inositol tetrakisphosphate phosphatase activity inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity enzyme regulator activity ubiquitin ligase activator activity enzyme activator activity ubiquitin-protein transferase regulator activity molecular function activator activity molecular function regulator activity ubiquitin-protein transferase activator activity protein binding binding PDZ domain binding protein domain specific binding protein tyrosine phosphatase activity protein-containing complex binding anaphase-promoting complex binding lipid binding phosphatidylinositol bisphosphate phosphatase activity phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity phosphatidylinositol-3,4-bisphosphate phosphatase activity phosphatidylinositol phosphate phosphatase activity ubiquitin-specific protease binding enzyme binding protease binding myosin phosphatase activity phosphatidylinositol trisphosphate phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity identical protein binding molecular function inhibitor activity phosphatidylinositol-3-phosphate phosphatase activity phosphatidylinositol monophosphate phosphatase activity	cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality positive regulation of cellular process trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling developmental process heart development multicellular organism development anatomical structure development animal organ development circulatory system development system development regulation of protein stability protein stabilization canonical Wnt signaling pathway Wnt signaling pathway protein dephosphorylation dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process negative regulation of locomotion regulation of cell motility regulation of response to external stimulus negative regulation of biological process negative regulation of wound healing, spreading of epidermal cells regulation of response to wounding response to stress regulation of response to stress regulation of cell migration negative regulation of cellular process cell migration response to wounding cell motility regulation of wound healing, spreading of epidermal cells locomotion negative regulation of cell migration wound healing epithelium development negative regulation of response to stimulus negative regulation of wound healing morphogenesis of an epithelium response to external stimulus negative regulation of response to wounding epiboly involved in wound healing tissue development morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis anatomical structure morphogenesis negative regulation of response to external stimulus regulation of locomotion regulation of wound healing epiboly negative regulation of cell motility wound healing, spreading of cells positive regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process apoptotic process cell death programmed cell death regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process negative regulation of protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process negative regulation of protein phosphorylation negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process growth organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth regulation of organ growth negative regulation of multicellular organismal process regulation of catalytic activity positive regulation of protein metabolic process regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification regulation of ubiquitin protein ligase activity positive regulation of metabolic process positive regulation of ubiquitin protein ligase activity positive regulation of protein modification process protein ubiquitination positive regulation of macromolecule metabolic process regulation of ubiquitin-protein transferase activity regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination positive regulation of transferase activity regulation of post-translational protein modification positive regulation of catalytic activity positive regulation of ubiquitin-protein transferase activity post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal head development brain morphogenesis forebrain development brain development nervous system development forebrain morphogenesis central nervous system development animal organ morphogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation dendritic spine morphogenesis cellular component organization or biogenesis synapse organization dendritic spine development plasma membrane bounded cell projection organization dendritic spine organization postsynapse organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation generation of neurons cell junction organization neuron development neuron projection organization regulation of epithelial to mesenchymal transition regulation of cell differentiation mesenchyme development negative regulation of cell differentiation negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation behavior rhythmic process circadian behavior locomotory behavior rhythmic behavior circadian rhythm locomotor rhythm axonogenesis regulation of neurogenesis regulation of cell development negative regulation of cellular component organization regulation of cell projection organization negative regulation of axonogenesis regulation of neuron projection development regulation of cellular component organization regulation of nervous system development negative regulation of neurogenesis regulation of axonogenesis negative regulation of nervous system development negative regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of multicellular organismal development axon development negative regulation of neuron projection development negative regulation of cell development regulation of plasma membrane bounded cell projection organization regulation of vascular associated smooth muscle cell proliferation negative regulation of cell population proliferation cell population proliferation regulation of smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation neuron-neuron synaptic transmission phosphatidylinositol metabolic process glycerophospholipid metabolic process lipid modification phospholipid metabolic process organophosphate metabolic process phosphatidylinositol dephosphorylation phospholipid dephosphorylation glycerolipid metabolic process lipid metabolic process membrane organization presynapse organization membrane biogenesis presynaptic membrane assembly membrane assembly cellular component biogenesis presynaptic membrane organization cellular component assembly cell junction assembly synapse assembly presynapse assembly glial cell development gliogenesis axon ensheathment ensheathment of neurons plasma membrane organization endomembrane system organization oligodendrocyte development central nervous system myelination central nervous system myelin maintenance myelination axon ensheathment in central nervous system oligodendrocyte differentiation glial cell differentiation myelin maintenance maternal behavior parental behavior reproductive process multicellular organismal reproductive process reproductive behavior adult behavior regulation of peptidyl-serine phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation peptidyl-amino acid modification negative regulation of peptidyl-serine phosphorylation postsynaptic density organization organelle assembly postsynaptic specialization assembly postsynapse assembly excitatory synapse assembly organelle organization postsynaptic specialization organization postsynaptic density assembly negative regulation of cell cycle negative regulation of catalytic activity regulation of cyclin-dependent protein kinase activity negative regulation of kinase activity negative regulation of transferase activity regulation of cyclin-dependent protein serine/threonine kinase activity cell cycle regulation of kinase activity regulation of protein serine/threonine kinase activity negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of protein serine/threonine kinase activity regulation of cell cycle negative regulation of cyclin-dependent protein kinase activity negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity positive regulation of cell population proliferation biological process involved in intraspecies interaction between organisms social behavior regulation of cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition negative regulation of cell cycle process cell cycle G1/S phase transition negative regulation of cell cycle phase transition cell cycle process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of cell size regulation of cellular component size regulation of cell size regulation of anatomical structure size rhythmic synaptic transmission multicellular organismal response to stress startle response neuromuscular process prepulse inhibition negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of cell communication negative regulation of signal transduction developmental maturation synapse maturation response to electrical stimulus cellular response to electrical stimulus response to abiotic stimulus cellular response to abiotic stimulus cellular response to environmental stimulus cell-substrate junction assembly negative regulation of cell-substrate junction organization negative regulation of cell-matrix adhesion negative regulation of cell adhesion cell adhesion negative regulation of cell junction assembly regulation of cell-substrate junction organization focal adhesion assembly regulation of cell-substrate adhesion regulation of cell adhesion cell-substrate adhesion regulation of cellular component biogenesis negative regulation of focal adhesion assembly regulation of cell junction assembly cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization negative regulation of cell-substrate adhesion regulation of focal adhesion assembly regulation of cell-substrate junction assembly regulation of keratinocyte migration tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration epithelial cell migration negative regulation of keratinocyte migration regulation of epithelial cell migration epithelium migration keratinocyte migration catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis protein catabolic process regulation of catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process modification-dependent protein catabolic process positive regulation of proteolysis ubiquitin-dependent protein catabolic process central nervous system neuron development central nervous system neuron differentiation central nervous system neuron axonogenesis glycerophospholipid biosynthetic process lipid biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process glycerolipid biosynthetic process organophosphate biosynthetic process mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition regulation of cellular senescence cellular senescence negative regulation of cellular senescence cellular response to stress vesicle localization regulation of localization cellular localization transport regulation of transport negative regulation of synaptic vesicle clustering synaptic vesicle clustering synaptic vesicle cycle negative regulation of transport establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse localization organelle localization establishment of localization in cell regulation of synaptic vesicle clustering synaptic vesicle localization learning or memory cognition dentate gyrus development pallium development telencephalon development hippocampus development limbic system development negative regulation of excitatory postsynaptic potential meiotic chromosome segregation sexual reproduction microtubule cytoskeleton organization membraneless organelle assembly female gamete generation meiotic cell cycle process gamete generation female meiotic nuclear division meiotic nuclear division chromosome segregation spindle organization organelle fission meiotic cell cycle meiotic spindle organization meiotic spindle assembly spindle assembly nuclear division nuclear chromosome segregation microtubule-based process cytoskeleton organization spindle assembly involved in female meiosis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol myelin sheath adaxonal region myelin sheath neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse cellular anatomical structure intracellular anatomical structure cytoplasm cytosol myelin sheath adaxonal region myelin sheath neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse cell junction dendrite dendritic tree cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular region membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen compact myelin Schmidt-Lanterman incisure postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A	IPR029023	Tensin-type phosphatase domain	Domain
A	IPR014020	Tensin phosphatase, C2 domain	Domain
A	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A	IPR051281	Dual-specificity lipid and protein phosphatase	Family
A	IPR045101	PTEN, phosphatase domain	Domain
A	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A	IPR035892	C2 domain superfamily	Homologous Superfamily
A	IPR017361	Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P60484	Cowden disease prostate cancer Bannayan-Riley-Ruvalcaba syndrome macrocephaly-autism syndrome Noonan syndrome with multiple lentigines head and neck squamous cell carcinoma Proteus syndrome malignant glioma melanoma lipoma breast cancer cancer endometrial cancer lipomatosis nasopharyngeal carcinoma Cowden disease prostate cancer Bannayan-Riley-Ruvalcaba syndrome macrocephaly-autism syndrome Noonan syndrome with multiple lentigines head and neck squamous cell carcinoma Proteus syndrome malignant glioma melanoma lipoma breast cancer cancer endometrial cancer lipomatosis nasopharyngeal carcinoma cholangiocarcinoma familial meningioma secretory meningioma Lhermitte-Duclos disease meningioma polydactyly long QT syndrome intellectual disability renal cell carcinoma granular cell carcinoma hemangioma placental hemangioma hepatocellular adenoma spinal meningioma hypertensive disorder adenocarcinoma Neoplasm Metastasis cerebral convexity meningioma tubular adenocarcinoma adenoid cystic carcinoma intramuscular hemangioma clear cell meningioma asthma sarcomatoid renal cell carcinoma Cowden syndrome 1 benign meningioma papillary renal cell carcinoma leukemia pleomorphic lipoma meningothelial meningioma microcystic meningioma breast carcinoma carcinoma endometrial carcinoma psammomatous meningioma lymphoma transitional meningioma epithelioid hemangioma angiomatous meningioma olfactory groove meningioma intraorbital meningioma salivary gland adenoid cystic carcinoma generalized juvenile polyposis/juvenile polyposis coli Sezary syndrome malignant pancreatic neoplasm glioma susceptibility 2 parasagittal meningioma cutaneous melanoma small cell lung carcinoma developmental coordination disorder mixed glioma prostate intraepithelial neoplasia endometrial hyperplasia non-small cell lung carcinoma intrahepatic cholangiocarcinoma chromophobe renal cell carcinoma VACTERL with hydrocephalus anisometropia oligodendroglioma intraventricular meningioma collecting duct carcinoma sarcomatoid carcinoma familial prostate carcinoma fibrous meningioma ovarian cancer glioblastoma papillary meningioma laryngeal squamous cell carcinoma cribriform carcinoma small cell carcinoma brain disease hereditary breast ovarian cancer syndrome lung adenocarcinoma myopathy lung carcinoma stomach disease lymphatic system disease thyroid gland carcinoma intestinal disease uterine disease familial melanoma oral cavity squamous cell carcinoma invasive ductal breast carcinoma colorectal adenocarcinoma atypical teratoid rhabdoid tumor ovarian carcinoma juvenile polyposis syndrome congenital anemia glioma autism spectrum disorder pancreatic ductal adenocarcinoma simple endometrial hyperplasia cribriform carcinoma of breast melanoma, cutaneous malignant, susceptibility to, 1 hepatocellular carcinoma liver disease developmental disability hibernoma prostate disease lung benign neoplasm activated PI3K-delta syndrome lung disease cerebrovascular disorder endometriosis undifferentiated carcinoma renal carcinoma clear cell renal carcinoma fatty liver disease astrocytic tumor osteosarcoma ischemia reperfusion injury colorectal cancer auditory perceptual disorders ovarian disease kidney disease pancreatic neoplasm large cell medulloblastoma skin disease bone disease hematologic disease breast adenocarcinoma hereditary breast carcinoma breast disease prostate adenocarcinoma squamous cell carcinoma of lip hydrocephalus lung cancer dysplastic nevus syndrome acute megakaryoblastic leukemia IgA glomerulonephritis Proteus-like syndrome thyroid cancer, nonmedullary, 2 PTEN hamartoma tumor syndrome lymphoplasmacyte-rich meningioma endometrium carcinoma in situ tuberculosis urinary bladder cancer atypical endometrial hyperplasia juvenile dermatomyositis complex endometrial hyperplasia segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome autism ovarian neoplasm silicosis

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	dual-specificity phosphatase M-CSA #456	This is a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. It also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Its peptide phosphatase activity requires highly acidic substrates.	Defined by 3 residues: ASP:A-86 [auth A-92]CYS:A-118 [auth A-124]ARG:A-124 [auth A-130] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 3.1.3.48 (PDB Primary Data) Search M-CSA Motif + EC 3.1.3.48 EC: 3.1.3.67 (UniProt) Search M-CSA Motif + EC 3.1.3.67 EC: 3.1.3 (UniProt) Search M-CSA Motif + EC 3.1.3 EC: 3.1.3.16 (UniProt) Search M-CSA Motif + EC 3.1.3.16

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.