Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1dpxa_ Alpha and beta proteins (a+b) Lysozyme-like Lysozyme-like C-type lysozyme Lysozyme (Gallus gallus ) [TaxId: 9031 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyLysozyme-like 8037428 3001879 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ALyse1dpxA1 A: a+b complex topologyX: Lysozyme-like (From Homology)H: Lysozyme-likeT: Lysozyme-likeF: LysECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.530.10 Mainly Alpha Orthogonal Bundle Lysozyme CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00062C-type lysozyme/alpha-lactalbumin family (Lys)C-type lysozyme/alpha-lactalbumin familyAlpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bac ...Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
LYSOZYME

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
lysozyme (glycosyl hydrolase 22 family)  M-CSA #203

Lysozymes have primarily a bacteriolytic function, it hydrolyses specific bonds between NAG and NAM in peptidoglycan, which forms the bacterial cell wall. Lysosymes in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents.

Historically there has been much debate about the mechanism of the enzyme, but recent evidence overwhelmingly supports the presence of a covalently bound intermediate. This discredits the Phillips mechanism which proposed an oxycarbenium intermediate.

Defined by 6 residues: GLU:A-35ASN:A-46ASP:A-48SER:A-50ASP:A-52ASN:A-59
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