Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyTrypsin-like serine proteases 8035341 3000114 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyEGF/Laminin-like 8035338 3000412 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATrypsine1g2lA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrel 2F: TrypsinECOD (1.6)
BFXa_inhibitione1g2lB1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: FXa_inhibitionECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.40.10.10 Mainly Beta Beta Barrel Thrombin, subunit H Trypsin-like serine proteasesCATH (4.3.0)
B2.10.25.10 Mainly Beta Ribbon Laminin LamininCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00089Trypsin (Trypsin)Trypsin- Domain
PF14670Coagulation Factor Xa inhibitory site (FXa_inhibition)Coagulation Factor Xa inhibitory siteThis short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442 [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
COAGULATION FACTOR X
COAGULATION FACTOR X

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
IPR018097EGF-like calcium-binding, conserved siteConserved Site
IPR000742EGF-like domainDomain
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
IPR050442Peptidase S1 family, coagulation factorsFamily
IPR009003Peptidase S1, PA clanHomologous Superfamily
IPR017857Coagulation factor-like, Gla domain superfamilyHomologous Superfamily
IPR001314Peptidase S1A, chymotrypsin familyFamily
IPR033116Serine proteases, trypsin family, serine active siteActive Site
IPR001254Serine proteases, trypsin domainDomain
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
IPR001881EGF-like calcium-binding domainDomain
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
IPR000152EGF-type aspartate/asparagine hydroxylation sitePTM
IPR012224Peptidase S1A, coagulation factor VII/IX/X/C/ZFamily
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
IPR018097EGF-like calcium-binding, conserved siteConserved Site
IPR000742EGF-like domainDomain
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
IPR050442Peptidase S1 family, coagulation factorsFamily
IPR009003Peptidase S1, PA clanHomologous Superfamily
IPR017857Coagulation factor-like, Gla domain superfamilyHomologous Superfamily
IPR001314Peptidase S1A, chymotrypsin familyFamily
IPR033116Serine proteases, trypsin family, serine active siteActive Site
IPR001254Serine proteases, trypsin domainDomain
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
IPR001881EGF-like calcium-binding domainDomain
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
IPR000152EGF-type aspartate/asparagine hydroxylation sitePTM
IPR012224Peptidase S1A, coagulation factor VII/IX/X/C/ZFamily