Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1gyta1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ad1gyta2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Bd1gytb1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Bd1gytb2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Cd1gytc1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Cd1gytc2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Dd1gytd1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Dd1gytd2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ed1gyte1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ed1gyte2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Fd1gytf1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Fd1gytf2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Gd1gytg1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Gd1gytg2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Hd1gyth1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Hd1gyth2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Id1gyti1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Id1gyti2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Jd1gytj1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Jd1gytj2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Kd1gytk1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Kd1gytk2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ld1gytl1 Alpha and beta proteins (a/b) Macro domain-like Macro domain-like Leucine aminopeptidase (Aminopeptidase A), N-terminal domain Leucine aminopeptidase (Aminopeptidase A), N-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)
Ld1gytl2 Alpha and beta proteins (a/b) Phosphorylase/hydrolase-like Zn-dependent exopeptidases Leucine aminopeptidase, C-terminal domain Leucine aminopeptidase, C-terminal domain (Escherichia coli K-12 ) [TaxId: 83333 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyPepA N-terminal domain-like 8026942 4000505 SCOP2 (2022-06-29)
ASCOP2 FamilyLeucine aminopeptidase, C-terminal domain 8026945 4000584 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyMacro domain-like 8039321 3000458 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyMacro domain-like 8039321 3000458 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyZn-dependent exopeptidases 8039324 3000662 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APeptidase_M17e1gytA1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
APeptidase_M17_Ne1gytA2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
BPeptidase_M17e1gytB1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
BPeptidase_M17_Ne1gytB2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
CPeptidase_M17e1gytC1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
CPeptidase_M17_Ne1gytC2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
DPeptidase_M17e1gytD1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
DPeptidase_M17_Ne1gytD2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
EPeptidase_M17e1gytE1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
EPeptidase_M17_Ne1gytE2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
FPeptidase_M17e1gytF1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
FPeptidase_M17_Ne1gytF2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
GPeptidase_M17e1gytG1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
GPeptidase_M17_Ne1gytG2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
HPeptidase_M17e1gytH1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
HPeptidase_M17_Ne1gytH2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
IPeptidase_M17e1gytI1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
IPeptidase_M17_Ne1gytI2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
JPeptidase_M17e1gytJ1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
JPeptidase_M17_Ne1gytJ2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
KPeptidase_M17e1gytK1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
KPeptidase_M17_Ne1gytK2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)
LPeptidase_M17e1gytL1 A: a/b three-layered sandwichesX: Phosphorylase/hydrolase-likeH: Zn-dependent exopeptidases (From Topology)T: Zn-dependent exopeptidasesF: Peptidase_M17ECOD (1.6)
LPeptidase_M17_Ne1gytL2 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Peptidase_M17_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
A3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
B3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
B3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
C3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
C3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
D3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
D3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
E3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
E3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
F3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
F3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
G3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
G3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
H3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
H3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
I3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
I3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
J3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
J3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
K3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
K3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)
L3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)
L3.40.630.10 Alpha Beta 3-Layer(aba) Sandwich Aminopeptidase Zn peptidasesCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02789Cytosol aminopeptidase family, N-terminal domain (Peptidase_M17_N)Cytosol aminopeptidase family, N-terminal domain- Domain
A, B, C, D, E
PF00883Cytosol aminopeptidase family, catalytic domain (Peptidase_M17)Cytosol aminopeptidase family, catalytic domainThe two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine aminopeptidase.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
CYTOSOL AMINOPEPTIDASE

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR008283Peptidase M17, leucyl aminopeptidase, N-terminalDomain
A, B, C, D, E
IPR000819Peptidase M17, leucyl aminopeptidase, C-terminalDomain
A, B, C, D, E
IPR011356Peptidase M17, leucine aminopeptidase/peptidase BFamily
A, B, C, D, E
IPR043472Macro domain-likeHomologous Superfamily
A, B, C, D, E
IPR023042Peptidase M17, leucine aminopeptidaseFamily