Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyAdenylylcyclase toxin N-terminal domain-like 8025532 4003589 SCOP2 (2022-06-29)
ASCOP2 FamilyAdenylylcyclase toxin C-terminal domain-like 8054299 4007636 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyNucleotidyltransferase-like 8037911 3000129 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyPAP/OAS1 substrate-binding domain-like 8054301 3000941 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AEUF08089e1k8tA1 A: alpha bundlesX: Alpha-helical domain in adenylylcyclase toxin (From Topology)H: Alpha-helical domain in adenylylcyclase toxin (From Topology)T: Alpha-helical domain in adenylylcyclase toxinF: EUF08089ECOD (1.6)
AAnthrax_toxA_Ce1k8tA2 A: a+b two layersX: Insertion domain in adenylylcyclase toxin (the edema factor) (From Topology)H: Insertion domain in adenylylcyclase toxin (the edema factor) (From Topology)T: Insertion domain in adenylylcyclase toxin (the edema factor)F: Anthrax_toxA_CECOD (1.6)
AAnthrax_toxA_Ne1k8tA3 A: a+b three layersX: N-terminal a+b domain in adenylylcyclase toxin (From Topology)H: N-terminal a+b domain in adenylylcyclase toxin (From Topology)T: N-terminal a+b domain in adenylylcyclase toxinF: Anthrax_toxA_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.90.1760.10 Alpha Beta Alpha-Beta Complex Adenylylcyclase toxin fold Anthrax toxin, edema factor, central domainCATH (4.3.0)
A1.20.140.60 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF20850Oedema factor (EF), alpha-helical domain (EF_HD)Oedema factor (EF), alpha-helical domainThis domain is found in Oedema factor (EF), the exotoxin with adenylyl cyclase activity produced by Bacillus anthracis to increase the concentration of cyclic AMP in infected host cells and disrupts intracellular signalling pathways. EF consists of f ...This domain is found in Oedema factor (EF), the exotoxin with adenylyl cyclase activity produced by Bacillus anthracis to increase the concentration of cyclic AMP in infected host cells and disrupts intracellular signalling pathways. EF consists of four domains: a PA-binding domain (PABD), two adenylate cyclase domains (ACD) and a helical domain (HD, this entry). HD moves and forms a large clamp that almost completely encircles EF's activator calmodulin (CaM), naturally present in host cells, stabilizing a disordered loop and leading to enzyme activation [1,4].
Domain
PF03497Anthrax toxin LF subunit (Anthrax_toxA)Anthrax toxin LF subunit- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
CALMODULIN-SENSITIVE ADENYLATE CYCLASE