Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B Superfamilyalpha/beta-Hydrolases 8042208 3000102 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ACOesterasee1mahA1 A: a/b three-layered sandwichesX: alpha/beta-Hydrolases (From Topology)H: alpha/beta-Hydrolases (From Topology)T: alpha/beta-HydrolasesF: COesteraseECOD (1.6)
B [auth F]Toxin_TOLIPe1mahF1 A: few secondary structure elementsX: Snake toxin-like (From Topology)H: Snake toxin-like (From Topology)T: Snake toxin-likeF: Toxin_TOLIPECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.1820 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Alpha/Beta hydrolase fold, catalytic domainCATH (4.3.0)
B [auth F]2.10.60.10 Mainly Beta Ribbon CD59 CD59CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00135Carboxylesterase family (COesterase)Carboxylesterase family- Domain
B [auth F]PF21947Snake toxin cobra-type (Toxin_cobra-type)Snake toxin cobra-type- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
ACETYLCHOLINESTERASE
B [auth F]FASCICULIN 2 -

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
acetylcholinesterase  M-CSA #922

This enzyme is found in, or attached to, cellular or basement membranes of presynaptic cholinergic neurons and postsynaptic cholinoceptive cells within the neuromuscular junction. Signal transmission at the neuromuscular junction involves the release of acylcholine, its interaction with the acycholine receptor and hydrolysis, all occuring in a period of a few milliseconds. Rapid hydrolysis of the newly released aceytlcholine is vital in order to prevent continuous firing of the nerve impulses [PMID:8161450].

Defined by 8 residues: GLY:A-121GLY:A-122SER:A-203ALA:A-204PHE:A-295GLU:A-334PHE:A-338HIS:A-447
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