1WUV

Crystal structure of native Canavalia gladiata lectin (CGL): a tetrameric ConA-like lectin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1wuva_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Legume lectins	automated matches	(Canavalia gladiata ) [TaxId: 3824 ], (Canavalia gladiata ) [TaxId: 3824 ],	SCOPe (2.08)
B [auth D]	d1wuvd_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Legume lectins	automated matches	(Canavalia gladiata ) [TaxId: 3824 ], (Canavalia gladiata ) [TaxId: 3824 ],	SCOPe (2.08)
C [auth G]	d1wuvg_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Legume lectins	automated matches	(Canavalia gladiata ) [TaxId: 3824 ], (Canavalia gladiata ) [TaxId: 3824 ],	SCOPe (2.08)
D [auth J]	d1wuvj_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Legume lectins	automated matches	(Canavalia gladiata ) [TaxId: 3824 ], (Canavalia gladiata ) [TaxId: 3824 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lectin_legB	e1wuvA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Lectin_legB	ECOD (1.6)
B [auth D]	Lectin_legB	e1wuvD1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Lectin_legB	ECOD (1.6)
C [auth G]	Lectin_legB	e1wuvG1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Lectin_legB	ECOD (1.6)
D [auth J]	Lectin_legB	e1wuvJ1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Lectin_legB	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
B [auth D]	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
C [auth G]	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
D [auth J]	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C [auth G], D [auth J]	PF00139	Legume lectin domain (Lectin_legB)	Legume lectin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C [auth G], D [auth J]	Concanavalin A	binding D-mannose binding monosaccharide binding carbohydrate binding small molecule binding cation binding ion binding metal ion binding	regulation of cellular process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus regulation of defense response to virus defense response to virus regulation of response to stimulus defense response to other organism response to stress regulation of response to stress response to external biotic stimulus response to virus positive regulation of cell division positive regulation of biological process cell division positive regulation of cellular process regulation of cell division positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C [auth G], D [auth J]	IPR001220	Legume lectin domain	Domain
A, B [auth D], C [auth G], D [auth J]	IPR000985	Legume lectin, alpha chain, conserved site	Conserved Site
A, B [auth D], C [auth G], D [auth J]	IPR050258	Leguminous Lectin	Family
A, B [auth D], C [auth G], D [auth J]	IPR016363	Legume lectin	Family
A, B [auth D], C [auth G], D [auth J]	IPR019825	Legume lectin, beta chain, Mn/Ca-binding site	Binding Site
A, B [auth D], C [auth G], D [auth J]	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.