Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyL domain-like 8038760 3001010 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyGrowth factor receptor domain-like 8038763 3000398 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
C [auth D]V-set_8e1yy9D1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
C [auth D]C1-set_1e1yy9D2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
ARecep_L_domaine1yy9A1 A: beta duplicates or obligate multimersX: Single-stranded right-handed beta-helixH: Leucine-rich repeats (From Topology)T: Leucine-rich repeatsF: Recep_L_domainECOD (1.6)
AGF_recep_IVe1yy9A5 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: GF_recep_IVECOD (1.6)
AFurin-likee1yy9A4 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: Furin-likeECOD (1.6)
B [auth C]C1-set_4e1yy9C2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
B [auth C]V-sete1yy9C1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
C [auth D]IMC-C225 VH-CH1 Chimeric (chimeric) IGHV2-2*03, IGHJ3*01, IGHG1*03 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202444-0)
B [auth C]IMC-C225 L-KAPPA Chimeric (chimeric) IGKV5-48*01, IGKJ5*01, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202444-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
C [auth D]Heavy ChainIGHV2 -epidermal growth factor receptorSAbDab (2024-11-08)
B [auth C]Light ChainIGKV5 Kappaepidermal growth factor receptorSAbDab (2024-11-08)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

ChainNameTargetProvenance Source
C [auth D] Tomuzotuximab EGFR/ERBB1/HER1, ERBB3/HER3Therapeutic SAbDab (2024-11-08)
B [auth C] Cetuximab EGFR/ERBB1/HER1, ERBB3/HER3Therapeutic SAbDab (2024-11-08)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00757Furin-like cysteine rich region (Furin-like)Furin-like cysteine rich region- Domain
PF01030Receptor L domain (Recep_L_domain)Receptor L domain- Repeat
PF14843Growth factor receptor domain IV (GF_recep_IV)Growth factor receptor domain IVThis is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
C [auth D]Cetuximab Fab Heavy chain---
Epidermal Growth Factor Receptor
B [auth C]Cetuximab Fab Light chain---

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP00533