2I2W

Crystal Structure of Escherichia Coli Phosphoheptose Isomerase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2i2wa_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2i2wb_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d2i2wc_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d2i2wd_	Alpha and beta proteins (a/b)	SIS domain	SIS domain	automated matches	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8088716	3001397	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8088716	3001397	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8088716	3001397	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SIS domain/Ribosomal protein S2-like	8088716	3001397	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SIS	e2i2wA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: SIS	ECOD (1.6)
B	SIS	e2i2wB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: SIS	ECOD (1.6)
C	SIS	e2i2wC1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: SIS	ECOD (1.6)
D	SIS	e2i2wD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Ribosomal protein S2/SIS domain (From Topology)	T: Ribosomal protein S2/SIS domain	F: SIS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10490	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glucose-6-phosphate isomerase like protein	CATH (4.3.0)
B	3.40.50.10490	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glucose-6-phosphate isomerase like protein	CATH (4.3.0)
C	3.40.50.10490	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glucose-6-phosphate isomerase like protein	CATH (4.3.0)
D	3.40.50.10490	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glucose-6-phosphate isomerase like protein	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF13580	SIS domain (SIS_2)	SIS domain	SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Phosphoheptose isomerase	binding carbohydrate derivative binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding identical protein binding protein binding isomerase activity D-sedoheptulose 7-phosphate isomerase activity intramolecular phosphotransferase activity catalytic activity binding carbohydrate derivative binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding identical protein binding protein binding isomerase activity D-sedoheptulose 7-phosphate isomerase activity intramolecular phosphotransferase activity catalytic activity intramolecular transferase activity	protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis lipopolysaccharide biosynthetic process cellular biosynthetic process lipid biosynthetic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis lipopolysaccharide biosynthetic process cellular biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process lipopolysaccharide metabolic process lipopolysaccharide core region biosynthetic process polysaccharide metabolic process oligosaccharide biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process oligosaccharide metabolic process cellular metabolic process liposaccharide metabolic process primary metabolic process lipopolysaccharide core region metabolic process macromolecule biosynthetic process biosynthetic process metabolic process macromolecule metabolic process lipid metabolic process D-glycero-D-manno-heptose 7-phosphate biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process D-glycero-D-manno-heptose 7-phosphate metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR046348	SIS domain superfamily	Homologous Superfamily
A, B, C, D	IPR004515	Phosphoheptose isomerase	Family
A, B, C, D	IPR035461	GmhA/DiaA	Family
A, B, C, D	IPR050099	SIS family GmhA and DiaA subfamilies	Family
A, B, C, D	IPR001347	SIS domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.