2LJ1

The third SH3 domain of R85FL with ataxin-7 PRR

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2lj1a_	All beta proteins	SH3-like barrel	SH3-domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SH3-domain	8062082	4000369	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SH3-domain	8062083	3000153	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e2lj1A1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14604	Variant SH3 domain (SH3_9)	Variant SH3 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sorbin and SH3 domain-containing protein 1	cytoskeletal protein binding protein binding binding signaling receptor binding insulin receptor binding actin binding signaling receptor complex adaptor activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity	cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane regulation of generation of precursor metabolites and energy positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of glycogen metabolic process positive regulation of metabolic process regulation of small molecule metabolic process small molecule metabolic process positive regulation of macromolecule metabolic process carbohydrate biosynthetic process primary metabolic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process biosynthetic process metabolic process energy reserve metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of carbohydrate metabolic process regulation of glycogen metabolic process regulation of metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process positive regulation of biosynthetic process regulation of carbohydrate metabolic process regulation of glucose metabolic process regulation of biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process glycogen metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process glycogen biosynthetic process macromolecule biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process glucose metabolic process actomyosin structure organization actin cytoskeleton organization actin filament organization cellular component organization cellular component biogenesis organelle organization cellular component assembly actin filament bundle organization contractile actin filament bundle assembly actin filament-based process actin filament bundle assembly stress fiber assembly cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization regulation of lipid metabolic process lipid biosynthetic process positive regulation of lipid biosynthetic process positive regulation of lipid metabolic process regulation of lipid biosynthetic process lipid metabolic process cellular response to nitrogen compound cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling response to peptide hormone regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus positive regulation of cellular response to insulin stimulus regulation of signaling cell surface receptor signaling pathway response to endogenous stimulus regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus regulation of response to stimulus response to chemical response to insulin regulation of cell communication cellular response to insulin stimulus positive regulation of signaling focal adhesion assembly cell-substrate junction assembly cell junction organization cell junction assembly cell-substrate junction organization hexose transmembrane transport D-glucose import transport carbohydrate transport positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import regulation of transport establishment of localization transmembrane transport regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix anchoring junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix anchoring junction cell junction focal adhesion cell-substrate junction centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol cell periphery plasma membrane membrane membrane microdomain membrane raft cell-cell junction apical junction complex adherens junction zonula adherens protein-containing complex plasma membrane protein complex plasma membrane raft membrane protein complex caveola flotillin complex plasma membrane region actin filament bundle actin cytoskeleton actomyosin stress fiber contractile actin filament bundle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035606	Sorbin and SH3 domain-containing protein 1, third SH3 domain	Domain
A	IPR003127	SoHo domain	Domain
A	IPR050384	Endophilin/SH3RF	Family
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR035611	Sorbin and SH3 domain-containing protein 1, second SH3 domain	Domain
A	IPR001452	SH3 domain	Domain
A	IPR035610	Sorbin and SH3 domain-containing protein 1, first SH3 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BX66	oligodendroglioma pituitary cancer adrenal cortex carcinoma atypical teratoid rhabdoid tumor breast fibroadenoma hereditary spastic paraplegia lung adenocarcinoma malignant ependymoma medulloblastoma ovarian cancer psoriasis astrocytic tumor breast cancer ductal breast carcinoma in situ invasive ductal breast carcinoma oligodendroglioma pituitary cancer adrenal cortex carcinoma atypical teratoid rhabdoid tumor breast fibroadenoma hereditary spastic paraplegia lung adenocarcinoma malignant ependymoma medulloblastoma ovarian cancer psoriasis astrocytic tumor breast cancer ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant mesothelioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma ulcerative colitis atopic eczema breast carcinoma glioblastoma large cell medulloblastoma malignant colon neoplasm Malignant neoplasm of breast

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.