Annotations: 2MYS

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2mysa1	All beta proteins	SH3-like barrel	Myosin S1 fragment, N-terminal domain	Myosin S1 fragment, N-terminal domain	Myosin S1 fragment, N-terminal domain	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
A	d2mysa2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Motor proteins	Myosin S1, motor domain	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d2mysb_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Myosin Essential Chain	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
C	d2mysc_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Myosin Regulatory Chain	(Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	EF-hand	8062903	3001983	SCOP2B (2022-06-29)
C	SCOP2 Family	Calmodulin-like	8024986	4000924	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	EF-hand	8037365	3001983	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Myosin_N	e2mysA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: Myosin_N	ECOD (1.6)
A	KOG0161_1st	e2mysA3	A: alpha bundles	X: Myosin VI lever arm (From Topology)	H: Myosin VI lever arm (From Topology)	T: Myosin VI lever arm	F: KOG0161_1st	ECOD (1.6)
A	Myosin_head	e2mysA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Myosin_head	ECOD (1.6)
B	EF-hand_7_8	e2mysB2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
B	EF-hand_7_4	e2mysB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_4	ECOD (1.6)
C	EF-hand_7_8	e2mysC1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
C	EF-hand_7_5	e2mysC2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.360	Mainly Beta	Roll	SH3 type barrels.	Myosin S1 fragment, N-terminal	CATH (4.3.0)
A	3.40.850.10	Alpha Beta	3-Layer(aba) Sandwich	Kinesin	Kinesin motor domain	CATH (4.3.0)
A	1.10.10.820	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A		CATH (4.3.0)
A	1.20.120.720	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Myosin VI head, motor domain, U50 subdomain	CATH (4.3.0)
A	1.20.58.530	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.20.5.4820	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02736	Myosin N-terminal SH3-like domain (Myosin_N)	Myosin N-terminal SH3-like domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	Domain
A	PF00063	Myosin head (motor domain) (Myosin_head)	Myosin head (motor domain)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	MYOSIN	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding calmodulin binding cytoskeletal motor activity microfilament motor activity ATP-dependent activity	multicellular organismal process system process muscle contraction muscle system process	protein-containing complex intracellular anatomical structure intracellular membraneless organelle actin cytoskeleton myosin complex intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle myosin II complex contractile muscle fiber cytoplasm supramolecular fiber protein-containing complex intracellular anatomical structure intracellular membraneless organelle actin cytoskeleton myosin complex intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle myosin II complex contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex myosin filament
B	MYOSIN	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	multicellular organismal process system process muscle contraction muscle system process developmental process muscle structure development skeletal muscle organ development skeletal muscle tissue development anatomical structure development animal organ development muscle tissue development muscle organ development tissue development striated muscle tissue development	cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle protein-containing complex cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton myosin complex
C	MYOSIN	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process myosin filament assembly myosin II filament assembly cellular component organization cellular component biogenesis regulation of myosin II filament assembly regulation of protein-containing complex assembly cellular component assembly actin filament-based process protein-containing complex assembly cellular component organization or biogenesis regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process myosin filament assembly myosin II filament assembly cellular component organization cellular component biogenesis regulation of myosin II filament assembly regulation of protein-containing complex assembly cellular component assembly actin filament-based process protein-containing complex assembly cellular component organization or biogenesis regulation of biological process actin cytoskeleton organization protein-containing complex organization biological regulation myosin filament organization regulation of myosin II filament organization regulation of cellular component biogenesis regulation of organelle organization myosin II filament organization organelle organization regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process supramolecular fiber organization cytoskeleton organization	intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton myosin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A	IPR001609	Myosin head, motor domain-like	Domain
A	IPR002928	Myosin tail	Domain
A	IPR004009	Myosin, N-terminal, SH3-like	Domain
A	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily
A	IPR000048	IQ motif, EF-hand binding site	Binding Site
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
B	IPR002048	EF-hand domain	Domain
B	IPR011992	EF-hand domain pair	Homologous Superfamily
B	IPR050403	Myosin regulatory light chain	Family
C	IPR050230	Calmodulin/Myosin light chain/Troponin C-like	Family
C	IPR002048	EF-hand domain	Domain
C	IPR011992	EF-hand domain pair	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	MLY	Parent Component: LYS RESID: AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.